ID   PSF3_DICDI              Reviewed;         265 AA.
AC   Q54EH6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Probable DNA replication complex GINS protein PSF3;
DE   AltName: Full=GINS complex subunit 3;
GN   Name=gins3; ORFNames=DDB_G0291506;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC       DNA replication. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC       gins1, gins2, gins3 and gins4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GINS3/PSF3 family. {ECO:0000305}.
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DR   EMBL; AAFI02000177; EAL61737.1; -; Genomic_DNA.
DR   RefSeq; XP_635264.1; XM_630172.1.
DR   AlphaFoldDB; Q54EH6; -.
DR   SMR; Q54EH6; -.
DR   STRING; 44689.DDB0266355; -.
DR   PaxDb; Q54EH6; -.
DR   EnsemblProtists; EAL61737; EAL61737; DDB_G0291506.
DR   GeneID; 8628209; -.
DR   KEGG; ddi:DDB_G0291506; -.
DR   dictyBase; DDB_G0291506; gins3.
DR   eggNOG; KOG1106; Eukaryota.
DR   HOGENOM; CLU_1051423_0_0_1; -.
DR   InParanoid; Q54EH6; -.
DR   OMA; IYKEGWR; -.
DR   PhylomeDB; Q54EH6; -.
DR   Reactome; R-DDI-176974; Unwinding of DNA.
DR   PRO; PR:Q54EH6; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0000811; C:GINS complex; ISS:dictyBase.
DR   GO; GO:0006260; P:DNA replication; ISS:dictyBase.
DR   GO; GO:1902975; P:mitotic DNA replication initiation; IBA:GO_Central.
DR   Gene3D; 1.20.58.2050; -; 1.
DR   InterPro; IPR021151; GINS_A.
DR   InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR   InterPro; IPR010492; GINS_Psf3.
DR   InterPro; IPR038437; GINS_Psf3_sf.
DR   PANTHER; PTHR22768; PTHR22768; 1.
DR   Pfam; PF05916; Sld5; 1.
DR   SUPFAM; SSF158573; SSF158573; 1.
PE   3: Inferred from homology;
KW   DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..265
FT                   /note="Probable DNA replication complex GINS protein PSF3"
FT                   /id="PRO_0000327618"
FT   REGION          180..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..252
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   265 AA;  30563 MW;  62983CCC8C6E138F CRC64;
     MSYFDINDIL AEEQKITCNF FYDAYNLGQL EEGSRDPDMK KGSKVDLPYW MALALAKSNF
     VSVIMPPEYQ DEYKNKLIAD PNVISMRLFP YYDKIGVQLS DFFGDRKLKL LLFRVFRERF
     LNIYSQSINL KETDISKILG NLTYQEREVF SNGYKSSNDY DKWMSRKGEK VEKNTNNLLI
     STSSNNKNNS SNSSNNNSNN NNNNNNNNNN NNNNNNNNNN NNSNSNSNSN SNSSNGNNNN
     NSQNSSYKNT QSTTVKKRKR MFDDE