ID   PSF3_PONAB              Reviewed;         216 AA.
AC   Q5RDV0;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=DNA replication complex GINS protein PSF3;
DE   AltName: Full=GINS complex subunit 3;
GN   Name=GINS3; Synonyms=PSF3;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC       DNA replication, and progression of DNA replication forks. GINS complex
CC       seems to bind preferentially to single-stranded DNA.
CC       {ECO:0000250|UniProtKB:Q9BRX5}.
CC   -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC       GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS2.
CC       GINS complex interacts with DNA primase in vitro (By similarity).
CC       Component of the CMG helicase complex, composed of the MCM2-7 complex,
CC       the GINS complex and CDC45 (By similarity).
CC       {ECO:0000250|UniProtKB:Q7ZT01, ECO:0000250|UniProtKB:Q9BRX5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7ZT01}.
CC       Chromosome {ECO:0000250|UniProtKB:Q7ZT01}. Note=Associates with
CC       chromatin. {ECO:0000250|UniProtKB:Q7ZT01}.
CC   -!- SIMILARITY: Belongs to the GINS3/PSF3 family. {ECO:0000305}.
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DR   EMBL; CR857794; CAH90057.1; -; mRNA.
DR   RefSeq; XP_002826522.1; XM_002826476.3.
DR   AlphaFoldDB; Q5RDV0; -.
DR   SMR; Q5RDV0; -.
DR   STRING; 9601.ENSPPYP00000008370; -.
DR   Ensembl; ENSPPYT00000060678; ENSPPYP00000036061; ENSPPYG00000007407.
DR   GeneID; 100442718; -.
DR   KEGG; pon:100442718; -.
DR   CTD; 64785; -.
DR   eggNOG; KOG1106; Eukaryota.
DR   GeneTree; ENSGT00390000001622; -.
DR   HOGENOM; CLU_081646_2_0_1; -.
DR   InParanoid; Q5RDV0; -.
DR   OMA; IYKEGWR; -.
DR   OrthoDB; 1291729at2759; -.
DR   TreeFam; TF314626; -.
DR   Proteomes; UP000001595; Chromosome 16.
DR   GO; GO:0071162; C:CMG complex; ISS:UniProtKB.
DR   GO; GO:0000811; C:GINS complex; IEA:Ensembl.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:Ensembl.
DR   GO; GO:1903934; P:positive regulation of DNA primase activity; IEA:Ensembl.
DR   GO; GO:1900264; P:positive regulation of DNA-directed DNA polymerase activity; IEA:Ensembl.
DR   Gene3D; 1.20.58.2050; -; 1.
DR   InterPro; IPR021151; GINS_A.
DR   InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR   InterPro; IPR010492; GINS_Psf3.
DR   InterPro; IPR038437; GINS_Psf3_sf.
DR   PANTHER; PTHR22768; PTHR22768; 1.
DR   Pfam; PF05916; Sld5; 1.
DR   SUPFAM; SSF158573; SSF158573; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..216
FT                   /note="DNA replication complex GINS protein PSF3"
FT                   /id="PRO_0000327617"
FT   REGION          1..16
FT                   /note="Not essential for folding and stability of GINS
FT                   complex, but may regulate accessibility to the central
FT                   complex pore"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   216 AA;  24533 MW;  A90B64A02401A5BF CRC64;
     MSEAYFRVES GALGPEENFL SLDDILMSHE KLPVRTETAM PRLGAFFLER SAGAETDNAV
     PQGSKLELPL WLAKGLFDNK RRILSVELPK IYQEGWRTVF SADPNVVDLH KMGPHFYGFG
     SQLLHFDSPE NADISQSLLQ TFIGRFRRIM DSSQNAYNED TSALVARLDE MERGLFQIGQ
     NGLNDFQCWE KGQASQITAS NLVQNYKKRK FTDMED