PSF3_XENLA
ID PSF3_XENLA Reviewed; 210 AA.
AC Q7ZT01; A0A1L8GLF1;
DT 02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=DNA replication complex GINS protein PSF3;
DE AltName: Full=GINS complex subunit 3;
GN Name=gins3 {ECO:0000312|Xenbase:XB-GENE-998293}; Synonyms=psf3;
GN ORFNames=XELAEV_18022837mg {ECO:0000312|EMBL:OCT84682.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, IDENTIFICATION IN THE GINS
RP COMPLEX, AND SUBCELLULAR LOCATION.
RX PubMed=12730133; DOI=10.1101/gad.1070003;
RA Kubota Y., Takase Y., Komori Y., Hashimoto Y., Arata T., Kamimura Y.,
RA Araki H., Takisawa H.;
RT "A novel ring-like complex of Xenopus proteins essential for the initiation
RT of DNA replication.";
RL Genes Dev. 17:1141-1152(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J;
RX PubMed=27762356; DOI=10.1038/nature19840;
RA Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S.,
RA Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J., Quigley I.,
RA Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B., Simakov O.,
RA Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T., Watanabe M.,
RA Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S., van Kruijsbergen I.,
RA Shu S., Carlson J., Kinoshita T., Ohta Y., Mawaribuchi S., Jenkins J.,
RA Grimwood J., Schmutz J., Mitros T., Mozaffari S.V., Suzuki Y., Haramoto Y.,
RA Yamamoto T.S., Takagi C., Heald R., Miller K., Haudenschild C., Kitzman J.,
RA Nakayama T., Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V.,
RA Karimi K., Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W.,
RA Shendure J., DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M.,
RA Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y., Veenstra G.J.,
RA Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.;
RT "Genome evolution in the allotetraploid frog Xenopus laevis.";
RL Nature 538:336-343(2016).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo, and Testis;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION IN THE CMG HELICASE COMPLEX.
RX PubMed=30979826; DOI=10.26508/lsa.201900390;
RA Priego Moreno S., Jones R.M., Poovathumkadavil D., Scaramuzza S.,
RA Gambus A.;
RT "Mitotic replisome disassembly depends on TRAIP ubiquitin ligase
RT activity.";
RL Life. Sci Alliance 2:0-0(2019).
RN [5]
RP IDENTIFICATION IN THE CMG HELICASE COMPLEX.
RX PubMed=30842657; DOI=10.1038/s41586-019-1002-0;
RA Wu R.A., Semlow D.R., Kamimae-Lanning A.N., Kochenova O.V., Chistol G.,
RA Hodskinson M.R., Amunugama R., Sparks J.L., Wang M., Deng L., Mimoso C.A.,
RA Low E., Patel K.J., Walter J.C.;
RT "TRAIP is a master regulator of DNA interstrand crosslink repair.";
RL Nature 567:267-272(2019).
CC -!- FUNCTION: Required for correct functioning of the GINS complex, a
CC complex that plays an essential role in the initiation of DNA
CC replication, and progression of DNA replication forks.
CC {ECO:0000269|PubMed:12730133}.
CC -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC gins1/psf1, gins2/psf2, gins3/psf3 and gins4/sld5 (PubMed:12730133).
CC Component of the CMG helicase complex, composed of the mcm2-7 complex,
CC the GINS complex and cdc45 (PubMed:30979826, PubMed:30842657).
CC {ECO:0000269|PubMed:12730133, ECO:0000269|PubMed:30842657,
CC ECO:0000269|PubMed:30979826}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12730133}. Chromosome
CC {ECO:0000269|PubMed:12730133}. Note=Associates with chromatin.
CC {ECO:0000269|PubMed:12730133}.
CC -!- SIMILARITY: Belongs to the GINS3/PSF3 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=OCT84682.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB097170; BAC66460.1; -; Genomic_DNA.
DR EMBL; CM004472; OCT84682.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC043845; AAH43845.1; -; mRNA.
DR EMBL; BC106314; AAI06315.1; -; mRNA.
DR RefSeq; NP_001080618.1; NM_001087149.1.
DR AlphaFoldDB; Q7ZT01; -.
DR SMR; Q7ZT01; -.
DR STRING; 8355.A0A1L8GLF1; -.
DR MaxQB; Q7ZT01; -.
DR DNASU; 380310; -.
DR GeneID; 380310; -.
DR KEGG; xla:380310; -.
DR CTD; 380310; -.
DR Xenbase; XB-GENE-998293; gins3.L.
DR OrthoDB; 1291729at2759; -.
DR Proteomes; UP000186698; Chromosome 4L.
DR Bgee; 380310; Expressed in oocyte and 19 other tissues.
DR GO; GO:0071162; C:CMG complex; IDA:UniProtKB.
DR GO; GO:0000811; C:GINS complex; IPI:UniProtKB.
DR GO; GO:0003682; F:chromatin binding; IC:UniProtKB.
DR GO; GO:0006260; P:DNA replication; IMP:UniProtKB.
DR Gene3D; 1.20.58.2050; -; 1.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR010492; GINS_Psf3.
DR InterPro; IPR038437; GINS_Psf3_sf.
DR PANTHER; PTHR22768; PTHR22768; 1.
DR Pfam; PF05916; Sld5; 1.
DR SUPFAM; SSF158573; SSF158573; 1.
PE 1: Evidence at protein level;
KW Chromosome; DNA replication; Nucleus; Reference proteome.
FT CHAIN 1..210
FT /note="DNA replication complex GINS protein PSF3"
FT /id="PRO_0000451424"
SQ SEQUENCE 210 AA; 23919 MW; B00178F1FB18B03B CRC64;
MWEPYMPVEP GLGREENFLS LEDLLMSQEK LPCCIESGFP RLGFLDKGGD SDSIPEGSKM
ELPLWLAKGL YDNKRRVLSV ELPKIYREGW RTVFSADANV VDLHKMGPHY YGFGSQLLNF
DSPENPEIAK TILQTFVGRF RRIMDSSQNA YNEDTSGLVA RLDELERSLF RAGQRGLNAF
QSWERGKAAQ ITASNLVQNY KKRKFNEADA
