PSG11_HUMAN
ID PSG11_HUMAN Reviewed; 335 AA.
AC Q9UQ72; Q13179; Q15242; Q8WW91; Q9UNE4;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Pregnancy-specific beta-1-glycoprotein 11;
DE Short=PS-beta-G-11;
DE Short=PSBG-11;
DE Short=Pregnancy-specific glycoprotein 11;
DE AltName: Full=Pregnancy-specific beta-1-glycoprotein 13;
DE Short=PS-beta-G-13;
DE Short=PSBG-13;
DE Short=Pregnancy-specific glycoprotein 13;
DE Flags: Precursor;
GN Name=PSG11; Synonyms=PSG13, PSG14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ASP-264.
RC TISSUE=Placenta;
RX PubMed=1840485; DOI=10.1016/0006-291x(91)90461-f;
RA Plouzek C.A., Watanabe S., Chou J.Y.;
RT "Cloning and expression of a new pregnancy-specific beta-1-glycoprotein
RT member.";
RL Biochem. Biophys. Res. Commun. 176:1532-1538(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
RC TISSUE=Liver;
RX PubMed=7794280; DOI=10.1006/bbrc.1995.1862;
RA Teglund S., Zhou G.Q., Hammarstroem S.;
RT "Characterization of cDNA encoding novel pregnancy-specific glycoprotein
RT variants.";
RL Biochem. Biophys. Res. Commun. 211:656-664(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ASP-264.
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143, AND VARIANT ILE-83.
RA Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.;
RT "Characterization of upstream promotor region, exon1 and exon2 of the PSG
RT gene family.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.
RA Fraengsmyr L., Teglund S., Israelsson A., Matsunaga T., Hammarstroem S.;
RT "CGM15-PSG13 intergenic sequence.";
RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9UQ72-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UQ72-2; Sequence=VSP_007876;
CC -!- DEVELOPMENTAL STAGE: PSBG are produced in high quantity during
CC pregnancy.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA36516.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAA75299.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAH20711.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; M69245; AAA36516.1; ALT_FRAME; mRNA.
DR EMBL; U25988; AAA75299.1; ALT_FRAME; mRNA.
DR EMBL; AC004784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC005947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC020711; AAH20711.2; ALT_INIT; mRNA.
DR EMBL; AH007522; AAD21024.1; -; Genomic_DNA.
DR EMBL; AF129398; AAD38357.1; -; Genomic_DNA.
DR CCDS; CCDS12614.2; -. [Q9UQ72-1]
DR CCDS; CCDS12615.2; -. [Q9UQ72-2]
DR PIR; JC4122; JC4122.
DR PIR; JN0067; JN0067.
DR RefSeq; NP_001106881.1; NM_001113410.1. [Q9UQ72-2]
DR RefSeq; NP_002776.3; NM_002785.2. [Q9UQ72-1]
DR RefSeq; NP_976032.2; NM_203287.1. [Q9UQ72-2]
DR AlphaFoldDB; Q9UQ72; -.
DR SMR; Q9UQ72; -.
DR BioGRID; 111653; 74.
DR IntAct; Q9UQ72; 4.
DR STRING; 9606.ENSP00000319140; -.
DR GlyGen; Q9UQ72; 3 sites.
DR iPTMnet; Q9UQ72; -.
DR PhosphoSitePlus; Q9UQ72; -.
DR BioMuta; PSG11; -.
DR DMDM; 296452992; -.
DR MassIVE; Q9UQ72; -.
DR PaxDb; Q9UQ72; -.
DR PeptideAtlas; Q9UQ72; -.
DR PRIDE; Q9UQ72; -.
DR ProteomicsDB; 85512; -. [Q9UQ72-1]
DR ProteomicsDB; 85513; -. [Q9UQ72-2]
DR Antibodypedia; 35052; 62 antibodies from 14 providers.
DR DNASU; 5680; -.
DR Ensembl; ENST00000306322.7; ENSP00000304913.6; ENSG00000243130.8. [Q9UQ72-2]
DR Ensembl; ENST00000320078.12; ENSP00000319140.7; ENSG00000243130.8. [Q9UQ72-1]
DR Ensembl; ENST00000403486.5; ENSP00000385427.1; ENSG00000243130.8. [Q9UQ72-2]
DR GeneID; 5680; -.
DR KEGG; hsa:5680; -.
DR MANE-Select; ENST00000320078.12; ENSP00000319140.7; NM_002785.3; NP_002776.3.
DR UCSC; uc002ovm.2; human. [Q9UQ72-1]
DR CTD; 5680; -.
DR DisGeNET; 5680; -.
DR GeneCards; PSG11; -.
DR HGNC; HGNC:9516; PSG11.
DR HPA; ENSG00000243130; Tissue enriched (placenta).
DR MIM; 176401; gene.
DR neXtProt; NX_Q9UQ72; -.
DR OpenTargets; ENSG00000243130; -.
DR PharmGKB; PA164742300; -.
DR VEuPathDB; HostDB:ENSG00000243130; -.
DR eggNOG; ENOG502RXPD; Eukaryota.
DR GeneTree; ENSGT00960000186634; -.
DR HOGENOM; CLU_024555_5_0_1; -.
DR InParanoid; Q9UQ72; -.
DR OMA; ISYLWWI; -.
DR OrthoDB; 998214at2759; -.
DR PhylomeDB; Q9UQ72; -.
DR TreeFam; TF336859; -.
DR PathwayCommons; Q9UQ72; -.
DR Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR SignaLink; Q9UQ72; -.
DR BioGRID-ORCS; 5680; 26 hits in 993 CRISPR screens.
DR ChiTaRS; PSG11; human.
DR GenomeRNAi; 5680; -.
DR Pharos; Q9UQ72; Tbio.
DR PRO; PR:Q9UQ72; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9UQ72; protein.
DR Bgee; ENSG00000243130; Expressed in endometrium epithelium and 108 other tissues.
DR ExpressionAtlas; Q9UQ72; baseline and differential.
DR Genevisible; Q9UQ72; HS.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007565; P:female pregnancy; TAS:ProtInc.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..335
FT /note="Pregnancy-specific beta-1-glycoprotein 11"
FT /id="PRO_0000014918"
FT DOMAIN 35..144
FT /note="Ig-like V-type"
FT DOMAIN 147..234
FT /note="Ig-like C2-type 1"
FT DOMAIN 242..317
FT /note="Ig-like C2-type 2"
FT MOTIF 127..129
FT /note="Cell attachment site"
FT /evidence="ECO:0000255"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 169..217
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 261..301
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 22..144
FT /note="ALLLNFWNLPTTAQVMIEAQPPKVSEGKDVLLLVHNLPQNLTGYIWYKGQIR
FT DLYHYITSYVVDGQIIIYGPAYSGRETVYSNASLLIQNVTREDAGSYTLHIIKRGDGTR
FT GVTGYFTFTLYL -> V (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_007876"
FT VARIANT 83
FT /note="V -> I (in dbSNP:rs2471952)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_061325"
FT VARIANT 176
FT /note="A -> T (in dbSNP:rs1058085)"
FT /id="VAR_056076"
FT VARIANT 264
FT /note="N -> D (in dbSNP:rs10414166)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:1840485"
FT /id="VAR_060365"
FT VARIANT 310
FT /note="E -> K (in dbSNP:rs10412348)"
FT /id="VAR_061326"
SQ SEQUENCE 335 AA; 37146 MW; 4C58685C2CA0FF29 CRC64;
MGPLSAPPCT EHIKWKGLLL TALLLNFWNL PTTAQVMIEA QPPKVSEGKD VLLLVHNLPQ
NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET VYSNASLLIQ NVTREDAGSY
TLHIIKRGDG TRGVTGYFTF TLYLETPKPS ISSSNLNPRE AMETVILTCN PETPDASYLW
WMNGQSLPMT HRMQLSETNR TLFLFGVTKY TAGPYECEIW NSGSASRSDP VTLNLLHGPD
LPRIFPSVTS YYSGENLDLS CFANSNPPAQ YSWTINGKFQ LSGQKLFIPQ ITPKHNGLYA
CSARNSATGE ESSTSLTIRV IAPPGLGTFA FNNPT
