PSG1_HUMAN
ID PSG1_HUMAN Reviewed; 419 AA.
AC P11464; O75236; P11462; P11463; Q15231; Q15241; Q15243; Q16660; Q6ICR4;
AC Q9P1W5; Q9UQ79;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1989, sequence version 1.
DT 03-AUG-2022, entry version 199.
DE RecName: Full=Pregnancy-specific beta-1-glycoprotein 1;
DE Short=PS-beta-G-1;
DE Short=PSBG-1;
DE Short=Pregnancy-specific glycoprotein 1;
DE AltName: Full=CD66 antigen-like family member F;
DE AltName: Full=Fetal liver non-specific cross-reactive antigen 1/2;
DE Short=FL-NCA-1/2;
DE AltName: Full=PSG95;
DE AltName: Full=Pregnancy-specific beta-1 glycoprotein C/D;
DE Short=PS-beta-C/D;
DE AltName: CD_antigen=CD66f;
DE Flags: Precursor;
GN Name=PSG1; Synonyms=B1G1, PSBG1, PSGGA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX PubMed=3260773; DOI=10.1016/0006-291x(88)90660-2;
RA Streydio C., Lacka K., Swillens S., Vassart G.;
RT "The human pregnancy-specific beta 1-glycoprotein (PS beta G) and the
RT carcinoembryonic antigen (CEA)-related proteins are members of the same
RT multigene family.";
RL Biochem. Biophys. Res. Commun. 154:130-137(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=3180995; DOI=10.1089/dna.1.1988.7.545;
RA Chan W.-Y., Borjigin J., Zheng Q.-X., Shupert W.L.;
RT "Characterization of cDNA encoding human pregnancy-specific beta 1-
RT glycoprotein from placenta and extraplacental tissues and their comparison
RT with carcinoembryonic antigen.";
RL DNA 7:545-555(1988).
RN [3]
RP NUCLEOTIDE SEQUENCE (ISOFORM 1).
RX PubMed=2735907; DOI=10.1016/0006-291x(89)92631-4;
RA Khan W.N., Hammarstroem S.;
RT "Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS-
RT beta-G/FL-NCA glycoprotein with a novel domain arrangement.";
RL Biochem. Biophys. Res. Commun. 161:525-535(1989).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4).
RX PubMed=2783133; DOI=10.1016/0006-291x(89)91105-4;
RA Zimmermann W.A., Weiss M., Thompson J.A.;
RT "cDNA cloning demonstrates the expression of pregnancy-specific
RT glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family,
RT in fetal liver.";
RL Biochem. Biophys. Res. Commun. 163:1197-1209(1989).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4).
RX PubMed=2377620; DOI=10.1073/pnas.87.15.5822;
RA Leslie K.K., Watanabe S., Lei K.-J., Chou D.Y., Plouzek C.A., Deng H.-C.,
RA Torres J., Chou J.Y.;
RT "Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is
RT associated with hydatidiform mole.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:5822-5826(1990).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RX PubMed=3257488; DOI=10.1016/s0021-9258(19)77983-6;
RA Watanabe S., Chou J.Y.;
RT "Isolation and characterization of complementary DNAs encoding human
RT pregnancy-specific beta 1-glycoprotein.";
RL J. Biol. Chem. 263:2049-2054(1988).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
RX PubMed=2541441; DOI=10.1073/pnas.86.9.3332;
RA Khan W.N., Osterman A., Hammarstroem S.;
RT "Molecular cloning and expression of cDNA for a carcinoembryonic antigen-
RT related fetal liver glycoprotein.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:3332-3336(1989).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
RX PubMed=2350345; DOI=10.1016/0006-291x(90)91455-2;
RA Zoubir F., Khan W.N., Hammarstroem S.;
RT "Carcinoembryonic antigen gene family members in submandibular salivary
RT gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning.";
RL Biochem. Biophys. Res. Commun. 169:203-216(1990).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [11]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [12]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [13]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.
RA Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.;
RT "Characterization of upstream promotor region, exon1 and exon2 of the PSG
RT gene family.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC P11464; O15294: OGT; NbExp=3; IntAct=EBI-716740, EBI-539828;
CC P11464; P01137: TGFB1; NbExp=3; IntAct=EBI-716740, EBI-779636;
CC P11464; PRO_0000033762 [P01137]: TGFB1; NbExp=2; IntAct=EBI-716740, EBI-15487336;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=PSG-1a;
CC IsoId=P11464-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P11464-2; Sequence=VSP_002550;
CC Name=3;
CC IsoId=P11464-3; Sequence=VSP_002549;
CC Name=4; Synonyms=PSG-1d;
CC IsoId=P11464-4; Sequence=VSP_002548;
CC -!- DEVELOPMENTAL STAGE: PSBG are produced in high quantity during
CC pregnancy.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC {ECO:0000305}.
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DR EMBL; M20881; AAA52603.1; -; mRNA.
DR EMBL; M20879; AAA52602.1; -; mRNA.
DR EMBL; M21822; AAA52601.1; -; mRNA.
DR EMBL; M25385; AAA36513.1; -; mRNA.
DR EMBL; M34715; AAA36511.1; -; mRNA.
DR EMBL; M17908; AAA52590.1; -; mRNA.
DR EMBL; M17909; AAA52591.1; -; mRNA.
DR EMBL; M33663; AAA36517.1; -; mRNA.
DR EMBL; M33664; AAA36515.1; -; mRNA.
DR EMBL; J04539; AAA60204.1; -; mRNA.
DR EMBL; M37397; AAA60960.1; -; mRNA.
DR EMBL; CR450329; CAG29325.1; -; mRNA.
DR EMBL; AC005238; AAC25488.1; -; Genomic_DNA.
DR EMBL; AC005238; AAC25489.1; -; Genomic_DNA.
DR EMBL; AC005238; AAC25490.1; -; Genomic_DNA.
DR EMBL; CH471126; EAW57156.1; -; Genomic_DNA.
DR EMBL; BC022338; AAH22338.1; -; mRNA.
DR EMBL; BC058285; AAH58285.1; -; mRNA.
DR EMBL; AH007517; AAD21020.1; -; Genomic_DNA.
DR CCDS; CCDS12612.1; -. [P11464-4]
DR CCDS; CCDS54275.1; -. [P11464-1]
DR CCDS; CCDS59392.1; -. [P11464-3]
DR CCDS; CCDS74380.1; -. [P11464-2]
DR PIR; A27658; A27658.
DR PIR; A28277; A28277.
DR PIR; A33258; A33258.
DR PIR; A35341; A35341.
DR PIR; A35964; A35964.
DR PIR; B33258; B33258.
DR PIR; C43354; C43354.
DR PIR; D43354; D43354.
DR PIR; E32268; A31135.
DR PIR; E43354; E43354.
DR RefSeq; NP_001171754.1; NM_001184825.1. [P11464-1]
DR RefSeq; NP_001171755.1; NM_001184826.1. [P11464-3]
DR RefSeq; NP_001284702.1; NM_001297773.1. [P11464-2]
DR RefSeq; NP_008836.2; NM_006905.2. [P11464-4]
DR AlphaFoldDB; P11464; -.
DR SMR; P11464; -.
DR BioGRID; 111644; 52.
DR IntAct; P11464; 33.
DR STRING; 9606.ENSP00000308970; -.
DR GlyGen; P11464; 7 sites.
DR iPTMnet; P11464; -.
DR PhosphoSitePlus; P11464; -.
DR BioMuta; PSG1; -.
DR DMDM; 129661; -.
DR MassIVE; P11464; -.
DR MaxQB; P11464; -.
DR PaxDb; P11464; -.
DR PeptideAtlas; P11464; -.
DR PRIDE; P11464; -.
DR ProteomicsDB; 52775; -. [P11464-1]
DR ProteomicsDB; 52776; -. [P11464-2]
DR ProteomicsDB; 52777; -. [P11464-3]
DR ProteomicsDB; 52778; -. [P11464-4]
DR Antibodypedia; 35155; 225 antibodies from 26 providers.
DR DNASU; 5669; -.
DR Ensembl; ENST00000244296.6; ENSP00000244296.2; ENSG00000231924.10. [P11464-4]
DR Ensembl; ENST00000312439.10; ENSP00000308970.6; ENSG00000231924.10. [P11464-2]
DR Ensembl; ENST00000436291.7; ENSP00000413041.2; ENSG00000231924.10. [P11464-1]
DR Ensembl; ENST00000595356.5; ENSP00000472610.1; ENSG00000231924.10. [P11464-3]
DR GeneID; 5669; -.
DR KEGG; hsa:5669; -.
DR MANE-Select; ENST00000436291.7; ENSP00000413041.2; NM_001184825.2; NP_001171754.1.
DR UCSC; uc002ouz.3; human. [P11464-1]
DR CTD; 5669; -.
DR DisGeNET; 5669; -.
DR GeneCards; PSG1; -.
DR HGNC; HGNC:9514; PSG1.
DR HPA; ENSG00000231924; Tissue enriched (placenta).
DR MIM; 176390; gene.
DR neXtProt; NX_P11464; -.
DR OpenTargets; ENSG00000231924; -.
DR PharmGKB; PA33861; -.
DR VEuPathDB; HostDB:ENSG00000231924; -.
DR eggNOG; ENOG502RXPD; Eukaryota.
DR GeneTree; ENSGT00960000186634; -.
DR HOGENOM; CLU_024555_2_0_1; -.
DR InParanoid; P11464; -.
DR OMA; TINGMFL; -.
DR OrthoDB; 998214at2759; -.
DR PhylomeDB; P11464; -.
DR TreeFam; TF336859; -.
DR PathwayCommons; P11464; -.
DR Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR SignaLink; P11464; -.
DR BioGRID-ORCS; 5669; 8 hits in 997 CRISPR screens.
DR ChiTaRS; PSG1; human.
DR GeneWiki; PSG1_(gene); -.
DR GenomeRNAi; 5669; -.
DR Pharos; P11464; Tbio.
DR PRO; PR:P11464; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P11464; protein.
DR Bgee; ENSG00000231924; Expressed in placenta and 53 other tissues.
DR ExpressionAtlas; P11464; baseline and differential.
DR Genevisible; P11464; HS.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:1990782; F:protein tyrosine kinase binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; TAS:ProtInc.
DR GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 4.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF13895; Ig_2; 2.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; SSF48726; 4.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..34
FT CHAIN 35..419
FT /note="Pregnancy-specific beta-1-glycoprotein 1"
FT /id="PRO_0000014908"
FT DOMAIN 35..144
FT /note="Ig-like V-type"
FT DOMAIN 149..234
FT /note="Ig-like C2-type 1"
FT DOMAIN 240..327
FT /note="Ig-like C2-type 2"
FT DOMAIN 335..410
FT /note="Ig-like C2-type 3"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 199
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 259
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 268
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 303
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 169..217
FT /evidence="ECO:0000305"
FT DISULFID 262..310
FT /evidence="ECO:0000305"
FT DISULFID 354..394
FT /evidence="ECO:0000305"
FT VAR_SEQ 415..419
FT /note="DWTVP -> AYSSSINYTSGNRN (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:3260773"
FT /id="VSP_002550"
FT VAR_SEQ 415..419
FT /note="DWTVP -> EAL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:3257488"
FT /id="VSP_002549"
FT VAR_SEQ 415..419
FT /note="DWTVP -> GKWIPASLAIGF (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:2350345, ECO:0000303|PubMed:2377620,
FT ECO:0000303|PubMed:2541441, ECO:0000303|PubMed:2783133,
FT ECO:0000303|Ref.9"
FT /id="VSP_002548"
FT VARIANT 41
FT /note="E -> Q (in dbSNP:rs707744)"
FT /id="VAR_056063"
FT VARIANT 43
FT /note="T -> P (in dbSNP:rs707745)"
FT /id="VAR_056064"
FT VARIANT 47
FT /note="E -> K (in dbSNP:rs1058956)"
FT /id="VAR_056065"
FT VARIANT 63
FT /note="T -> A (in dbSNP:rs1064479)"
FT /id="VAR_056066"
FT VARIANT 73
FT /note="R -> K (in dbSNP:rs1064480)"
FT /id="VAR_056067"
FT VARIANT 87
FT /note="E -> Q (in dbSNP:rs1058661)"
FT /id="VAR_056068"
FT VARIANT 101
FT /note="A -> V (in dbSNP:rs707748)"
FT /id="VAR_056069"
FT VARIANT 125
FT /note="I -> V (in dbSNP:rs1058960)"
FT /id="VAR_059408"
FT VARIANT 134
FT /note="V -> E (in dbSNP:rs1058671)"
FT /id="VAR_056070"
FT VARIANT 197
FT /note="E -> K (in dbSNP:rs1058692)"
FT /id="VAR_056071"
FT VARIANT 198
FT /note="T -> N (in dbSNP:rs1058693)"
FT /id="VAR_056072"
FT CONFLICT 41..43
FT /note="EPT -> QPP (in Ref. 4, 5 and 6)"
FT /evidence="ECO:0000305"
FT CONFLICT 319
FT /note="I -> V (in Ref. 5 and 6)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 419 AA; 47223 MW; 5E9855162F0C796D CRC64;
MGTLSAPPCT QRIKWKGLLL TASLLNFWNL PTTAQVTIEA EPTKVSEGKD VLLLVHNLPQ
NLTGYIWYKG QMRDLYHYIT SYVVDGEIII YGPAYSGRET AYSNASLLIQ NVTREDAGSY
TLHIIKGDDG TRGVTGRFTF TLHLETPKPS ISSSNLNPRE TMEAVSLTCD PETPDASYLW
WMNGQSLPMT HSLKLSETNR TLFLLGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP
KPYITINNLN PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYRSGEVL YLSCSADSNP
PAQYSWTINE KFQLPGQKLF IRHITTKHSG LYVCSVRNSA TGKESSKSMT VEVSDWTVP
