PSG2_HUMAN
ID PSG2_HUMAN Reviewed; 335 AA.
AC P11465; Q8TCD9; Q9UEA4; Q9UQ78;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 172.
DE RecName: Full=Pregnancy-specific beta-1-glycoprotein 2;
DE Short=PS-beta-G-2;
DE Short=PSBG-2;
DE Short=Pregnancy-specific glycoprotein 2;
DE AltName: Full=Pregnancy-specific beta-1 glycoprotein E;
DE Short=PS-beta-E;
DE Flags: Precursor;
GN Name=PSG2; Synonyms=PSBG2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3260773; DOI=10.1016/0006-291x(88)90660-2;
RA Streydio C., Lacka K., Swillens S., Vassart G.;
RT "The human pregnancy-specific beta 1-glycoprotein (PS beta G) and the
RT carcinoembryonic antigen (CEA)-related proteins are members of the same
RT multigene family.";
RL Biochem. Biophys. Res. Commun. 154:130-137(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-20.
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.
RA Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.;
RT "Characterization of upstream promotor region, exon1 and exon2 of the PSG
RT gene family.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC {ECO:0000305}.
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DR EMBL; M20882; AAA52604.1; -; mRNA.
DR EMBL; AC005791; AAC62831.1; -; Genomic_DNA.
DR EMBL; AC024077; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC022316; AAH22316.1; -; mRNA.
DR EMBL; AH007518; AAD21021.1; -; Genomic_DNA.
DR CCDS; CCDS12616.1; -.
DR RefSeq; NP_112536.2; NM_031246.3.
DR AlphaFoldDB; P11465; -.
DR SMR; P11465; -.
DR BioGRID; 111645; 2.
DR IntAct; P11465; 1.
DR MINT; P11465; -.
DR STRING; 9606.ENSP00000385706; -.
DR GlyGen; P11465; 5 sites, 1 O-linked glycan (1 site).
DR iPTMnet; P11465; -.
DR PhosphoSitePlus; P11465; -.
DR BioMuta; PSG2; -.
DR DMDM; 108935879; -.
DR MassIVE; P11465; -.
DR PaxDb; P11465; -.
DR PeptideAtlas; P11465; -.
DR PRIDE; P11465; -.
DR ProteomicsDB; 52779; -.
DR Antibodypedia; 35051; 135 antibodies from 16 providers.
DR DNASU; 5670; -.
DR Ensembl; ENST00000406487.6; ENSP00000385706.1; ENSG00000242221.9.
DR GeneID; 5670; -.
DR KEGG; hsa:5670; -.
DR MANE-Select; ENST00000406487.6; ENSP00000385706.1; NM_031246.4; NP_112536.2.
DR UCSC; uc002ovr.4; human.
DR CTD; 5670; -.
DR DisGeNET; 5670; -.
DR GeneCards; PSG2; -.
DR HGNC; HGNC:9519; PSG2.
DR HPA; ENSG00000242221; Tissue enriched (placenta).
DR MIM; 176391; gene.
DR neXtProt; NX_P11465; -.
DR OpenTargets; ENSG00000242221; -.
DR PharmGKB; PA33864; -.
DR VEuPathDB; HostDB:ENSG00000242221; -.
DR eggNOG; ENOG502RWY0; Eukaryota.
DR GeneTree; ENSGT00960000186634; -.
DR HOGENOM; CLU_024555_2_0_1; -.
DR InParanoid; P11465; -.
DR OMA; HECEIWD; -.
DR OrthoDB; 998214at2759; -.
DR PhylomeDB; P11465; -.
DR TreeFam; TF336859; -.
DR PathwayCommons; P11465; -.
DR Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR SignaLink; P11465; -.
DR BioGRID-ORCS; 5670; 72 hits in 984 CRISPR screens.
DR GeneWiki; PSG2; -.
DR GenomeRNAi; 5670; -.
DR Pharos; P11465; Tbio.
DR PRO; PR:P11465; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P11465; protein.
DR Bgee; ENSG00000242221; Expressed in placenta and 79 other tissues.
DR ExpressionAtlas; P11465; baseline and differential.
DR Genevisible; P11465; HS.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016477; P:cell migration; NAS:UniProtKB.
DR GO; GO:0007565; P:female pregnancy; NAS:UniProtKB.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..34
FT CHAIN 35..335
FT /note="Pregnancy-specific beta-1-glycoprotein 2"
FT /id="PRO_0000014909"
FT DOMAIN 35..144
FT /note="Ig-like V-type"
FT DOMAIN 147..234
FT /note="Ig-like C2-type 1"
FT DOMAIN 239..317
FT /note="Ig-like C2-type 2"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 199
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 169..217
FT /evidence="ECO:0000305"
FT DISULFID 261..301
FT /evidence="ECO:0000305"
FT VARIANT 20
FT /note="V -> L (in dbSNP:rs3887660)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_016039"
FT VARIANT 176
FT /note="T -> A (in dbSNP:rs16976431)"
FT /id="VAR_049918"
FT VARIANT 179
FT /note="Q -> L (in dbSNP:rs1058086)"
FT /id="VAR_049919"
FT VARIANT 335
FT /note="T -> R (in dbSNP:rs1064937)"
FT /id="VAR_049920"
FT CONFLICT 310
FT /note="E -> Q (in Ref. 1; AAA52604)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 335 AA; 37216 MW; C47AFC14DED9C0F8 CRC64;
MGPLSAPPCT EHIKWKGLLV TASLLNFWNL PTTAQVTIEA QPPKVSEGKD VLLLVHNLPQ
NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET AYSNASLLIQ NVTREDAGSY
TLHIIKRGDG TRGVTGYFTF TLYLETPKPS ISSSNLNPRE AMETVILTCD PETPDTSYQW
WMNGQSLPMT HRFQLSETNR TLFLFGVTKY TAGPYECEIR NSGSASRSDP VTLNLLHGPD
LPRIHPSYTN YRSGDNLYLS CFANSNPPAQ YSWTINGKFQ QSGQNLFIPQ ITTKHSGLYV
CSVRNSATGE ESSTSLTVKV SASTRIGLLP LLNPT
