PSG3_HUMAN
ID PSG3_HUMAN Reviewed; 428 AA.
AC Q16557; Q08265; Q9BRW2; Q9UPL4; Q9UQ77;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 179.
DE RecName: Full=Pregnancy-specific beta-1-glycoprotein 3;
DE Short=PS-beta-G-3;
DE Short=PSBG-3;
DE Short=Pregnancy-specific glycoprotein 3;
DE AltName: Full=Carcinoembryonic antigen SG5;
DE Flags: Precursor;
GN Name=PSG3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS SER-23 AND PRO-30.
RX PubMed=2341148; DOI=10.1016/0888-7543(90)90492-d;
RA Streydio C., Swillens S., Georges M., Szpirer C., Vassart G.;
RT "Structure, evolution and chromosomal localization of the human pregnancy-
RT specific beta 1 glycoprotein gene family.";
RL Genomics 6:579-592(1990).
RN [2]
RP ERRATUM OF PUBMED:2341148.
RX PubMed=2387594; DOI=10.1016/0888-7543(90)90216-h;
RA Streydio C., Swillens S., Georges M., Szpirer C., Vassart G.;
RL Genomics 7:661-662(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS SER-23 AND PRO-30.
RX PubMed=3265688; DOI=10.1016/0378-1119(88)90061-3;
RA Rooney B.C., Horne C.H., Hardman N.;
RT "Molecular cloning of a cDNA for human pregnancy-specific beta 1-
RT glycoprotein: homology with human carcinoembryonic antigen and related
RT proteins.";
RL Gene 71:439-449(1988).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS SER-23 AND PRO-30.
RX PubMed=2350345; DOI=10.1016/0006-291x(90)91455-2;
RA Zoubir F., Khan W.N., Hammarstroem S.;
RT "Carcinoembryonic antigen gene family members in submandibular salivary
RT gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning.";
RL Biochem. Biophys. Res. Commun. 169:203-216(1990).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Colon;
RX PubMed=8487756; DOI=10.1007/bf00926089;
RA Shupert W.L., Chan W.Y.;
RT "Pregnancy specific beta 1-glycoprotein in human intestine.";
RL Mol. Cell. Biochem. 120:159-170(1993).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.
RA Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.;
RT "Characterization of upstream promotor region, exon 1 and exon 2 of the PSG
RT gene family.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 23-428, AND VARIANTS SER-23 AND PRO-30.
RC TISSUE=Testis;
RX PubMed=2302228; DOI=10.1016/0006-291x(90)90854-g;
RA Borjigin J., Tease L.A., Barnes W., Chan W.-Y.;
RT "Expression of the pregnancy-specific beta 1-glycoprotein genes in human
RT testis.";
RL Biochem. Biophys. Res. Commun. 166:622-629(1990).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: PSBG are produced in high quantity during
CC pregnancy.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC {ECO:0000305}.
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DR EMBL; M34420; AAA52606.1; -; mRNA.
DR EMBL; M23575; AAA52607.1; -; mRNA.
DR EMBL; M37399; AAA60958.1; -; mRNA.
DR EMBL; M93061; AAA60207.1; -; mRNA.
DR EMBL; S59493; AAC60584.1; -; mRNA.
DR EMBL; AC004654; AAC15513.1; -; Genomic_DNA.
DR EMBL; AC005337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC005924; AAH05924.2; -; mRNA.
DR EMBL; AH007624; AAD28498.1; -; Genomic_DNA.
DR CCDS; CCDS12611.1; -.
DR PIR; I57486; I57486.
DR PIR; JS0032; JS0032.
DR RefSeq; NP_066296.2; NM_021016.3.
DR AlphaFoldDB; Q16557; -.
DR SMR; Q16557; -.
DR BioGRID; 111646; 20.
DR IntAct; Q16557; 9.
DR MINT; Q16557; -.
DR STRING; 9606.ENSP00000332215; -.
DR GlyGen; Q16557; 4 sites.
DR iPTMnet; Q16557; -.
DR PhosphoSitePlus; Q16557; -.
DR BioMuta; PSG3; -.
DR DMDM; 108935880; -.
DR jPOST; Q16557; -.
DR MassIVE; Q16557; -.
DR PaxDb; Q16557; -.
DR PeptideAtlas; Q16557; -.
DR PRIDE; Q16557; -.
DR ProteomicsDB; 60913; -.
DR TopDownProteomics; Q16557; -.
DR Antibodypedia; 21555; 158 antibodies from 26 providers.
DR DNASU; 5671; -.
DR Ensembl; ENST00000327495.10; ENSP00000332215.5; ENSG00000221826.10.
DR Ensembl; ENST00000614582.1; ENSP00000480223.1; ENSG00000221826.10.
DR GeneID; 5671; -.
DR KEGG; hsa:5671; -.
DR MANE-Select; ENST00000327495.10; ENSP00000332215.5; NM_021016.4; NP_066296.2.
DR UCSC; uc002oue.4; human.
DR CTD; 5671; -.
DR DisGeNET; 5671; -.
DR GeneCards; PSG3; -.
DR HGNC; HGNC:9520; PSG3.
DR HPA; ENSG00000221826; Tissue enriched (placenta).
DR MIM; 176392; gene.
DR neXtProt; NX_Q16557; -.
DR OpenTargets; ENSG00000221826; -.
DR PharmGKB; PA33865; -.
DR VEuPathDB; HostDB:ENSG00000221826; -.
DR eggNOG; ENOG502RXPD; Eukaryota.
DR GeneTree; ENSGT00960000186634; -.
DR HOGENOM; CLU_024555_2_0_1; -.
DR InParanoid; Q16557; -.
DR OMA; TWTINRK; -.
DR OrthoDB; 998214at2759; -.
DR PhylomeDB; Q16557; -.
DR TreeFam; TF336859; -.
DR PathwayCommons; Q16557; -.
DR Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR SignaLink; Q16557; -.
DR BioGRID-ORCS; 5671; 14 hits in 985 CRISPR screens.
DR ChiTaRS; PSG3; human.
DR GeneWiki; PSG3; -.
DR GenomeRNAi; 5671; -.
DR Pharos; Q16557; Tbio.
DR PRO; PR:Q16557; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q16557; protein.
DR Bgee; ENSG00000221826; Expressed in placenta and 75 other tissues.
DR ExpressionAtlas; Q16557; baseline and differential.
DR Genevisible; Q16557; HS.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:1990782; F:protein tyrosine kinase binding; IBA:GO_Central.
DR GO; GO:0006952; P:defense response; TAS:UniProtKB.
DR GO; GO:0007565; P:female pregnancy; TAS:UniProtKB.
DR GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 4.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; SSF48726; 4.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..428
FT /note="Pregnancy-specific beta-1-glycoprotein 3"
FT /id="PRO_0000014910"
FT DOMAIN 35..144
FT /note="Ig-like V-type"
FT DOMAIN 147..234
FT /note="Ig-like C2-type 1"
FT DOMAIN 240..327
FT /note="Ig-like C2-type 2"
FT DOMAIN 335..410
FT /note="Ig-like C2-type 3"
FT MOTIF 127..129
FT /note="Cell attachment site"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 268
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 303
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 169..217
FT /evidence="ECO:0000305"
FT DISULFID 262..310
FT /evidence="ECO:0000305"
FT DISULFID 354..394
FT /evidence="ECO:0000305"
FT VARIANT 23
FT /note="L -> S (in dbSNP:rs11559136)"
FT /evidence="ECO:0000269|PubMed:2302228,
FT ECO:0000269|PubMed:2341148, ECO:0000269|PubMed:2350345,
FT ECO:0000269|PubMed:3265688"
FT /id="VAR_026722"
FT VARIANT 30
FT /note="L -> P (in dbSNP:rs12185496)"
FT /evidence="ECO:0000269|PubMed:2302228,
FT ECO:0000269|PubMed:2341148, ECO:0000269|PubMed:2350345,
FT ECO:0000269|PubMed:3265688"
FT /id="VAR_015679"
FT VARIANT 30
FT /note="L -> S (in dbSNP:rs12185496)"
FT /id="VAR_059409"
FT VARIANT 198
FT /note="N -> T (in dbSNP:rs16976174)"
FT /id="VAR_026723"
FT VARIANT 199
FT /note="K -> N (in dbSNP:rs17173152)"
FT /id="VAR_049921"
FT VARIANT 290
FT /note="I -> N (in dbSNP:rs28698193)"
FT /id="VAR_061323"
FT CONFLICT 330..383
FT /note="Missing (in Ref. 9)"
FT /evidence="ECO:0000305"
FT CONFLICT 412
FT /note="K -> E (in Ref. 7; AAH05924)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 428 AA; 47945 MW; 98750D7CDA426245 CRC64;
MGPLSAPPCT QRITWKGLLL TALLLNFWNL PTTAQVTIEA EPTKVSKGKD VLLLVHNLPQ
NLAGYIWYKG QMKDLYHYIT SYVVDGQIII YGPAYSGRET VYSNASLLIQ NVTREDAGSY
TLHIVKRGDG TRGETGHFTF TLYLETPKPS ISSSNLYPRE DMEAVSLTCD PETPDASYLW
WMNGQSLPMT HSLQLSKNKR TLFLFGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP
KPYITINNLN PRENKDVLAF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV
TRNETGPYQC EIQDRYGGIR SYPVTLNVLY GPDLPRIYPS FTYYHSGENL YLSCFADSNP
PAEYSWTING KFQLSGQKLF IPQITTKHSG LYACSVRNSA TGMESSKSMT VKVSAPSGTG
HLPGLNPL
