PSG4_HUMAN
ID PSG4_HUMAN Reviewed; 419 AA.
AC Q00888; E7EX79; Q13047; Q13048; Q15234; Q15240; Q9UQ76;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 199.
DE RecName: Full=Pregnancy-specific beta-1-glycoprotein 4;
DE Short=PS-beta-G-4;
DE Short=PSBG-4;
DE Short=Pregnancy-specific glycoprotein 4;
DE AltName: Full=Pregnancy-specific beta-1-glycoprotein 9;
DE Short=PS-beta-G-9;
DE Short=PSBG-9;
DE Short=Pregnancy-specific glycoprotein 9;
DE Flags: Precursor;
GN Name=PSG4; Synonyms=CGM4, PSG9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), AND VARIANT HIS-11.
RX PubMed=1690992; DOI=10.1016/0006-291x(90)92103-7;
RA Thompson J., Koumari R., Wagner K., Barnert S., Schleussner C., Schrewe H.,
RA Zimmermann W., Mueller G., Schempp W., Zaninetta D., Ammaturo D.,
RA Hardman N.;
RT "The human pregnancy-specific glycoprotein genes are tightly linked on the
RT long arm of chromosome 19 and are coordinately expressed.";
RL Biochem. Biophys. Res. Commun. 167:848-859(1990).
RN [2]
RP ERRATUM OF PUBMED:1690992.
RX PubMed=2346490;
RA Thompson J., Koumari R., Wagner K., Barnert S., Schleussner C., Schrewe H.,
RA Zimmermann W., Mueller G., Schempp W., Zaninetta D., Ammaturo D.,
RA Hardman N.;
RL Biochem. Biophys. Res. Commun. 168:1325-1325(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS HIS-11; VAL-75 AND
RP GLU-267.
RC TISSUE=Bone marrow;
RX PubMed=2271648; DOI=10.1021/bi00496a009;
RA Barnett T.R., Pickle W. II, Elting J.J.;
RT "Characterization of two new members of the pregnancy-specific beta 1-
RT glycoprotein family from the myeloid cell line KG-1 and suggestion of two
RT distinct classes of transcription unit.";
RL Biochemistry 29:10213-10218(1990).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS HIS-11; VAL-75 AND
RP GLU-267.
RX PubMed=1922019; DOI=10.1007/bf00230182;
RA Chan W.Y., Zheng Q.X., McMahon J., Tease L.A.;
RT "Characterization of new members of the pregnancy-specific beta 1-
RT glycoprotein family.";
RL Mol. Cell. Biochem. 106:161-170(1991).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANTS HIS-11; VAL-75
RP AND GLU-267.
RC TISSUE=Fetal liver;
RX PubMed=7794280; DOI=10.1006/bbrc.1995.1862;
RA Teglund S., Zhou G.Q., Hammarstroem S.;
RT "Characterization of cDNA encoding novel pregnancy-specific glycoprotein
RT variants.";
RL Biochem. Biophys. Res. Commun. 211:656-664(1995).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 210-419 (ISOFORM 1), AND VARIANT GLU-267.
RC TISSUE=Fetal liver;
RX PubMed=2783133; DOI=10.1016/0006-291x(89)91105-4;
RA Zimmermann W.A., Weiss M., Thompson J.A.;
RT "cDNA cloning demonstrates the expression of pregnancy-specific
RT glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family,
RT in fetal liver.";
RL Biochem. Biophys. Res. Commun. 163:1197-1209(1989).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-143.
RX PubMed=3180995; DOI=10.1089/dna.1.1988.7.545;
RA Chan W.-Y., Borjigin J., Zheng Q.-X., Shupert W.L.;
RT "Characterization of cDNA encoding human pregnancy-specific beta 1-
RT glycoprotein from placenta and extraplacental tissues and their comparison
RT with carcinoembryonic antigen.";
RL DNA 7:545-555(1988).
RN [9]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-43.
RA Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.;
RT "Characterization of upstream promotor region, exon 1 and exon 2 of the PSG
RT gene family.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q00888-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q00888-2; Sequence=VSP_007875, VSP_040131;
CC Name=3;
CC IsoId=Q00888-3; Sequence=VSP_055025;
CC -!- DEVELOPMENTAL STAGE: PSBG are produced in high quantity during
CC pregnancy.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA60208.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
CC Sequence=M32625; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; M32622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M32623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M32624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M32625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M32626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M32627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; X17097; CAA34956.1; -; mRNA.
DR EMBL; M94891; AAA60195.1; -; mRNA.
DR EMBL; U18468; AAA75294.1; -; mRNA.
DR EMBL; U18469; AAA75295.1; -; mRNA.
DR EMBL; AC005392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M33665; AAA60208.1; ALT_SEQ; mRNA.
DR EMBL; AH007625; AAD28499.1; -; Genomic_DNA.
DR CCDS; CCDS33039.1; -. [Q00888-2]
DR CCDS; CCDS46093.1; -. [Q00888-1]
DR CCDS; CCDS62695.1; -. [Q00888-3]
DR PIR; A36109; A36109.
DR PIR; B54312; B54312.
DR PIR; C33258; C33258.
DR PIR; JC4124; JC4124.
DR RefSeq; NP_002771.2; NM_002780.4. [Q00888-1]
DR RefSeq; NP_998798.1; NM_213633.2. [Q00888-2]
DR AlphaFoldDB; Q00888; -.
DR SMR; Q00888; -.
DR BioGRID; 111647; 6.
DR IntAct; Q00888; 5.
DR STRING; 9606.ENSP00000384770; -.
DR GlyGen; Q00888; 6 sites.
DR iPTMnet; Q00888; -.
DR PhosphoSitePlus; Q00888; -.
DR BioMuta; PSG4; -.
DR DMDM; 313104197; -.
DR jPOST; Q00888; -.
DR MassIVE; Q00888; -.
DR MaxQB; Q00888; -.
DR PaxDb; Q00888; -.
DR PeptideAtlas; Q00888; -.
DR PRIDE; Q00888; -.
DR ProteomicsDB; 19001; -.
DR ProteomicsDB; 57880; -. [Q00888-1]
DR ProteomicsDB; 57881; -. [Q00888-2]
DR Antibodypedia; 35053; 88 antibodies from 21 providers.
DR DNASU; 5672; -.
DR Ensembl; ENST00000244295.13; ENSP00000244295.8; ENSG00000243137.8. [Q00888-2]
DR Ensembl; ENST00000405312.8; ENSP00000384770.3; ENSG00000243137.8. [Q00888-1]
DR Ensembl; ENST00000433626.6; ENSP00000387864.2; ENSG00000243137.8. [Q00888-3]
DR GeneID; 5672; -.
DR KEGG; hsa:5672; -.
DR MANE-Select; ENST00000405312.8; ENSP00000384770.3; NM_002780.5; NP_002771.2.
DR UCSC; uc002ovy.4; human. [Q00888-1]
DR CTD; 5672; -.
DR DisGeNET; 5672; -.
DR GeneCards; PSG4; -.
DR HGNC; HGNC:9521; PSG4.
DR HPA; ENSG00000243137; Group enriched (parathyroid gland, placenta).
DR MIM; 176393; gene.
DR neXtProt; NX_Q00888; -.
DR OpenTargets; ENSG00000243137; -.
DR PharmGKB; PA33866; -.
DR VEuPathDB; HostDB:ENSG00000243137; -.
DR eggNOG; ENOG502RXPD; Eukaryota.
DR GeneTree; ENSGT00960000186634; -.
DR InParanoid; Q00888; -.
DR OMA; CEPSENY; -.
DR OrthoDB; 998214at2759; -.
DR PhylomeDB; Q00888; -.
DR TreeFam; TF336859; -.
DR PathwayCommons; Q00888; -.
DR Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR SignaLink; Q00888; -.
DR BioGRID-ORCS; 5672; 20 hits in 1013 CRISPR screens.
DR ChiTaRS; PSG4; human.
DR GeneWiki; PSG4; -.
DR GenomeRNAi; 5672; -.
DR Pharos; Q00888; Tbio.
DR PRO; PR:Q00888; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q00888; protein.
DR Bgee; ENSG00000243137; Expressed in placenta and 93 other tissues.
DR ExpressionAtlas; Q00888; baseline and differential.
DR Genevisible; Q00888; HS.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:1990782; F:protein tyrosine kinase binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; TAS:UniProtKB.
DR GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 4.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF13895; Ig_2; 2.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; SSF48726; 4.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..419
FT /note="Pregnancy-specific beta-1-glycoprotein 4"
FT /id="PRO_0000014911"
FT DOMAIN 35..144
FT /note="Ig-like V-type"
FT DOMAIN 147..234
FT /note="Ig-like C2-type 1"
FT DOMAIN 237..327
FT /note="Ig-like C2-type 2"
FT DOMAIN 332..410
FT /note="Ig-like C2-type 3"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 199
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 268
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 299
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 303
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 169..217
FT /evidence="ECO:0000305"
FT DISULFID 262..310
FT /evidence="ECO:0000305"
FT DISULFID 354..394
FT /evidence="ECO:0000305"
FT VAR_SEQ 144..236
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_055025"
FT VAR_SEQ 237..329
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:7794280"
FT /id="VSP_007875"
FT VAR_SEQ 330
FT /note="Y -> H (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:7794280"
FT /id="VSP_040131"
FT VARIANT 11
FT /note="Q -> H (in dbSNP:rs11883278)"
FT /evidence="ECO:0000269|PubMed:1690992,
FT ECO:0000269|PubMed:1922019, ECO:0000269|PubMed:2271648,
FT ECO:0000269|PubMed:7794280"
FT /id="VAR_060362"
FT VARIANT 75
FT /note="L -> V (in dbSNP:rs3170216)"
FT /evidence="ECO:0000269|PubMed:1922019,
FT ECO:0000269|PubMed:2271648, ECO:0000269|PubMed:7794280"
FT /id="VAR_016040"
FT VARIANT 177
FT /note="S -> R (in dbSNP:rs73548061)"
FT /id="VAR_060363"
FT VARIANT 240
FT /note="S -> P (in dbSNP:rs3859474)"
FT /id="VAR_056073"
FT VARIANT 267
FT /note="K -> E (in dbSNP:rs1058718)"
FT /evidence="ECO:0000269|PubMed:1922019,
FT ECO:0000269|PubMed:2271648, ECO:0000269|PubMed:2783133,
FT ECO:0000269|PubMed:7794280"
FT /id="VAR_060364"
FT VARIANT 286
FT /note="V -> A (in dbSNP:rs2355442)"
FT /id="VAR_056074"
FT CONFLICT 12
FT /note="R -> L (in Ref. 1; M32622, 3; CAA34956, 4; AAA60195
FT and 5; AAA75294/AAA75295)"
FT /evidence="ECO:0000305"
FT CONFLICT 18
FT /note="V -> L (in Ref. 4; AAA60195)"
FT /evidence="ECO:0000305"
FT CONFLICT 175
FT /note="A -> P (in Ref. 1; M32624)"
FT /evidence="ECO:0000305"
FT CONFLICT 352
FT /note="L -> F (in Ref. 3; CAA34956)"
FT /evidence="ECO:0000305"
FT CONFLICT 356
FT /note="A -> G (in Ref. 3; CAA34956)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 419 AA; 47113 MW; 576BFB4CBA502CC2 CRC64;
MGPLSAPPCT QRITWKGVLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD VLLLVHNLPQ
NLAGYIWYKG QMTYLYHYIT SYVVDGQRII YGPAYSGRER VYSNASLLIQ NVTQEDAGSY
TLHIIKRRDG TGGVTGHFTF TLHLETPKPS ISSSNLNPRE AMEAVILTCD PATPAASYQW
WMNGQSLPMT HRLQLSKTNR TLFIFGVTKY IAGPYECEIR NPVSASRSDP VTLNLLPKLS
KPYITINNLN PRENKDVLTF TCEPKSKNYT YIWWLNGQSL PVSPRVKRPI ENRILILPNV
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPSIYPS FTYYRSGENL YLSCFAESNP
RAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA TGKESSKSIT VKVSDWILP
