PSG5_HUMAN
ID PSG5_HUMAN Reviewed; 335 AA.
AC Q15238; Q15239; Q96QJ1; Q9UQ75;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 182.
DE RecName: Full=Pregnancy-specific beta-1-glycoprotein 5;
DE Short=PS-beta-G-5;
DE Short=PSBG-5;
DE Short=Pregnancy-specific glycoprotein 5;
DE AltName: Full=Fetal liver non-specific cross-reactive antigen 3;
DE Short=FL-NCA-3;
DE Flags: Precursor;
GN Name=PSG5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANTS VAL-18 AND HIS-227.
RC TISSUE=Placenta;
RX PubMed=2789512; DOI=10.1016/0006-291x(89)92324-3;
RA Oikawa S., Inuzuka C., Kuroki M., Matsuoka Y., Kosaki G., Nakazato H.;
RT "A pregnancy-specific beta 1-glycoprotein, a CEA gene family member,
RT expressed in a human promyelocytic leukemia cell line, HL-60: structures of
RT protein, mRNA and gene.";
RL Biochem. Biophys. Res. Commun. 163:1021-1031(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS VAL-18; LYS-154 AND HIS-227.
RC TISSUE=Placenta;
RX PubMed=1922019; DOI=10.1007/bf00230182;
RA Chan W.Y., Zheng Q.X., McMahon J., Tease L.A.;
RT "Characterization of new members of the pregnancy-specific beta 1-
RT glycoprotein family.";
RL Mol. Cell. Biochem. 106:161-170(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-18; LYS-154 AND
RP HIS-227.
RX PubMed=2735907; DOI=10.1016/0006-291x(89)92631-4;
RA Khan W.N., Hammarstroem S.;
RT "Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS-
RT beta-G/FL-NCA glycoprotein with a novel domain arrangement.";
RL Biochem. Biophys. Res. Commun. 161:525-535(1989).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS VAL-18 AND HIS-227.
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.
RA Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.;
RT "Characterization of upstream promotor region, exon 1 and exon 2 of the PSG
RT gene family.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- INTERACTION:
CC Q15238; P35590: TIE1; NbExp=3; IntAct=EBI-4314891, EBI-2256865;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Synthesized by syncytiotrophoblast of the placenta.
CC -!- DEVELOPMENTAL STAGE: PSBG are produced in high quantity during
CC pregnancy.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC {ECO:0000305}.
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DR EMBL; M73713; AAA60205.1; -; mRNA.
DR EMBL; M25384; AAA36514.1; -; mRNA.
DR EMBL; AC005392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC012607; AAH12607.1; -; mRNA.
DR EMBL; AH007626; AAD28500.1; -; Genomic_DNA.
DR CCDS; CCDS12617.1; -.
DR PIR; A33514; A33514.
DR PIR; B33251; B33251.
DR PIR; C54312; C54312.
DR RefSeq; NP_001123486.1; NM_001130014.1.
DR RefSeq; NP_002772.3; NM_002781.3.
DR RefSeq; XP_016882492.1; XM_017027003.1.
DR AlphaFoldDB; Q15238; -.
DR SMR; Q15238; -.
DR BioGRID; 111648; 4.
DR IntAct; Q15238; 3.
DR MINT; Q15238; -.
DR STRING; 9606.ENSP00000382334; -.
DR DrugBank; DB00523; Alitretinoin.
DR GlyGen; Q15238; 5 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q15238; -.
DR PhosphoSitePlus; Q15238; -.
DR BioMuta; PSG5; -.
DR DMDM; 311033414; -.
DR jPOST; Q15238; -.
DR MassIVE; Q15238; -.
DR PaxDb; Q15238; -.
DR PeptideAtlas; Q15238; -.
DR PRIDE; Q15238; -.
DR ProteomicsDB; 60495; -.
DR Antibodypedia; 21553; 55 antibodies from 16 providers.
DR DNASU; 5673; -.
DR Ensembl; ENST00000342951.11; ENSP00000344413.6; ENSG00000204941.14.
DR Ensembl; ENST00000366175.7; ENSP00000382334.2; ENSG00000204941.14.
DR Ensembl; ENST00000407356.5; ENSP00000386008.1; ENSG00000204941.14.
DR GeneID; 5673; -.
DR KEGG; hsa:5673; -.
DR MANE-Select; ENST00000342951.11; ENSP00000344413.6; NM_002781.4; NP_002772.3.
DR UCSC; uc002ovu.4; human.
DR CTD; 5673; -.
DR DisGeNET; 5673; -.
DR GeneCards; PSG5; -.
DR HGNC; HGNC:9522; PSG5.
DR HPA; ENSG00000204941; Tissue enriched (placenta).
DR MIM; 176394; gene.
DR neXtProt; NX_Q15238; -.
DR OpenTargets; ENSG00000204941; -.
DR PharmGKB; PA33867; -.
DR VEuPathDB; HostDB:ENSG00000204941; -.
DR eggNOG; ENOG502RWXZ; Eukaryota.
DR GeneTree; ENSGT00960000186634; -.
DR InParanoid; Q15238; -.
DR OMA; ENMESNY; -.
DR OrthoDB; 998214at2759; -.
DR PhylomeDB; Q15238; -.
DR TreeFam; TF336859; -.
DR PathwayCommons; Q15238; -.
DR Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR SignaLink; Q15238; -.
DR BioGRID-ORCS; 5673; 34 hits in 1022 CRISPR screens.
DR ChiTaRS; PSG5; human.
DR GeneWiki; PSG5; -.
DR GenomeRNAi; 5673; -.
DR Pharos; Q15238; Tbio.
DR PRO; PR:Q15238; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q15238; protein.
DR Bgee; ENSG00000204941; Expressed in placenta and 125 other tissues.
DR ExpressionAtlas; Q15238; baseline and differential.
DR Genevisible; Q15238; HS.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007565; P:female pregnancy; TAS:ProtInc.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF13895; Ig_2; 2.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..335
FT /note="Pregnancy-specific beta-1-glycoprotein 5"
FT /id="PRO_0000014912"
FT DOMAIN 35..144
FT /note="Ig-like V-type"
FT DOMAIN 147..234
FT /note="Ig-like C2-type 1"
FT DOMAIN 239..317
FT /note="Ig-like C2-type 2"
FT MOTIF 127..129
FT /note="Cell attachment site"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 210
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 169..217
FT /evidence="ECO:0000305"
FT DISULFID 261..301
FT /evidence="ECO:0000305"
FT VARIANT 18
FT /note="L -> V (in dbSNP:rs8107936)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:1922019, ECO:0000269|PubMed:2735907,
FT ECO:0000269|PubMed:2789512"
FT /id="VAR_060260"
FT VARIANT 154
FT /note="N -> K (in dbSNP:rs1058259)"
FT /evidence="ECO:0000269|PubMed:1922019,
FT ECO:0000269|PubMed:2735907"
FT /id="VAR_016041"
FT VARIANT 168
FT /note="T -> I (in dbSNP:rs5013158)"
FT /id="VAR_060261"
FT VARIANT 227
FT /note="R -> H (in dbSNP:rs1058285)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:1922019, ECO:0000269|PubMed:2735907,
FT ECO:0000269|PubMed:2789512"
FT /id="VAR_060262"
FT CONFLICT 15
FT /note="W -> C (in Ref. 2; AAA60205)"
FT /evidence="ECO:0000305"
FT CONFLICT 20
FT /note="L -> V (in Ref. 3; AAA36514)"
FT /evidence="ECO:0000305"
FT CONFLICT 195
FT /note="R -> Q (in Ref. 1; no nucleotide entry and 5;
FT AAH12607)"
FT /evidence="ECO:0000305"
FT CONFLICT 232
FT /note="T -> S (in Ref. 2; AAA60205 and 3; AAA36514)"
FT /evidence="ECO:0000305"
FT CONFLICT 240
FT /note="D -> Y (in Ref. 3; AAA36514)"
FT /evidence="ECO:0000305"
FT CONFLICT 288
FT /note="I -> M (in Ref. 3; AAA36514)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 335 AA; 37713 MW; E14EA6E9DAA88296 CRC64;
MGPLSAPPCT QHITWKGLLL TASLLNFWNL PITAQVTIEA LPPKVSEGKD VLLLVHNLPQ
NLAGYIWYKG QLMDLYHYIT SYVVDGQINI YGPAYTGRET VYSNASLLIQ NVTREDAGSY
TLHIIKRGDR TRGVTGYFTF NLYLKLPKPY ITINNSKPRE NKDVLAFTCE PKSENYTYIW
WLNGQSLPVS PRVKRPIENR ILILPSVTRN ETGPYECEIR DRDGGMRSDP VTLNVLYGPD
LPSIYPSFTY YRSGENLYLS CFAESNPPAE YFWTINGKFQ QSGQKLSIPQ ITTKHRGLYT
CSVRNSATGK ESSKSMTVEV SAPSGIGRLP LLNPI
