PSG6_HUMAN
ID PSG6_HUMAN Reviewed; 435 AA.
AC Q00889; O75244; Q15224; Q15235; Q549K1;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Pregnancy-specific beta-1-glycoprotein 6;
DE Short=PS-beta-G-6;
DE Short=PSBG-6;
DE Short=Pregnancy-specific glycoprotein 6;
DE AltName: Full=Pregnancy-specific beta-1-glycoprotein 10;
DE Short=PS-beta-G-10;
DE Short=PSBG-10;
DE Short=Pregnancy-specific glycoprotein 10;
DE AltName: Full=Pregnancy-specific beta-1-glycoprotein 12;
DE Short=PS-beta-G-12;
DE Short=PSBG-12;
DE Short=Pregnancy-specific glycoprotein 12;
DE Flags: Precursor;
GN Name=PSG6; Synonyms=CGM3, PSG10, PSG12, PSGGB;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Liver;
RX PubMed=2783133; DOI=10.1016/0006-291x(89)91105-4;
RA Zimmermann W.A., Weiss M., Thompson J.A.;
RT "cDNA cloning demonstrates the expression of pregnancy-specific
RT glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family,
RT in fetal liver.";
RL Biochem. Biophys. Res. Commun. 163:1197-1209(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT ASP-85.
RX PubMed=2346748; DOI=10.1021/bi00463a030;
RA Zheng Q.-X., Tease L.A., Shupert W.L., Chan W.-Y.;
RT "Characterization of cDNAs of the human pregnancy-specific beta-1-
RT glycoprotein family, a new subfamily of the immunoglobulin gene
RT superfamily.";
RL Biochemistry 29:2845-2852(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT ASP-85.
RC TISSUE=Bone marrow;
RX PubMed=2271648; DOI=10.1021/bi00496a009;
RA Barnett T.R., Pickle W. II, Elting J.J.;
RT "Characterization of two new members of the pregnancy-specific beta 1-
RT glycoprotein family from the myeloid cell line KG-1 and suggestion of two
RT distinct classes of transcription unit.";
RL Biochemistry 29:10213-10218(1990).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-142.
RX PubMed=1690992; DOI=10.1016/0006-291x(90)92103-7;
RA Thompson J., Koumari R., Wagner K., Barnert S., Schleussner C., Schrewe H.,
RA Zimmermann W., Mueller G., Schempp W., Zaninetta D., Ammaturo D.,
RA Hardman N.;
RT "The human pregnancy-specific glycoprotein genes are tightly linked on the
RT long arm of chromosome 19 and are coordinately expressed.";
RL Biochem. Biophys. Res. Commun. 167:848-859(1990).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-142.
RX PubMed=10686536; DOI=10.1159/000030112;
RA Fraengsmyr L., Israelsson A., Teglund S., Matsunaga T., Hammarstroem S.;
RT "Evolution of the carcinoembryonic antigen family. structures of CGM9,
RT CGM11 and pregnancy-specific glycoprotein promoters.";
RL Tumor Biol. 21:63-81(2000).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-142.
RX PubMed=2537643; DOI=10.1016/0006-291x(89)92821-0;
RA Thompson J.A., Mauch E.-M., Chen F.-S., Hinoda Y., Schrewe H., Berling B.,
RA Barnert S., von Kleist S., Shively J.E., Zimmermann W.;
RT "Analysis of the size of the carcinoembryonic antigen (CEA) gene family:
RT isolation and sequencing of N-terminal domain exons.";
RL Biochem. Biophys. Res. Commun. 158:996-1004(1989).
RN [9]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-142.
RX PubMed=2377620; DOI=10.1073/pnas.87.15.5822;
RA Leslie K.K., Watanabe S., Lei K.-J., Chou D.Y., Plouzek C.A., Deng H.-C.,
RA Torres J., Chou J.Y.;
RT "Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is
RT associated with hydatidiform mole.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:5822-5826(1990).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q00889-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q00889-2; Sequence=VSP_039344;
CC -!- DEVELOPMENTAL STAGE: PSBG are produced in high quantity during
CC pregnancy.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M33666; AAA60206.1; -; mRNA.
DR EMBL; M31125; AAA36512.1; -; mRNA.
DR EMBL; X17098; CAA34957.1; -; mRNA.
DR EMBL; AC005260; AAC25619.1; -; Genomic_DNA.
DR EMBL; AC005260; AAC25620.1; -; Genomic_DNA.
DR EMBL; BC020652; AAH20652.1; -; mRNA.
DR EMBL; M32621; AAA60201.1; -; Genomic_DNA.
DR EMBL; M32620; AAA60201.1; JOINED; Genomic_DNA.
DR EMBL; AH007627; AAD28501.1; -; Genomic_DNA.
DR EMBL; AH002953; AAA60202.1; -; Genomic_DNA.
DR CCDS; CCDS12613.1; -. [Q00889-1]
DR CCDS; CCDS33038.1; -. [Q00889-2]
DR PIR; D33258; D33258.
DR RefSeq; NP_001027020.1; NM_001031850.3. [Q00889-2]
DR RefSeq; NP_002773.1; NM_002782.4. [Q00889-1]
DR AlphaFoldDB; Q00889; -.
DR SMR; Q00889; -.
DR BioGRID; 111650; 2.
DR IntAct; Q00889; 1.
DR MINT; Q00889; -.
DR STRING; 9606.ENSP00000292125; -.
DR GlyGen; Q00889; 7 sites.
DR iPTMnet; Q00889; -.
DR PhosphoSitePlus; Q00889; -.
DR BioMuta; PSG6; -.
DR DMDM; 1709853; -.
DR MassIVE; Q00889; -.
DR PaxDb; Q00889; -.
DR PeptideAtlas; Q00889; -.
DR PRIDE; Q00889; -.
DR ProteomicsDB; 57882; -. [Q00889-1]
DR ProteomicsDB; 57883; -. [Q00889-2]
DR Antibodypedia; 17548; 175 antibodies from 21 providers.
DR DNASU; 5675; -.
DR Ensembl; ENST00000187910.7; ENSP00000187910.3; ENSG00000170848.16. [Q00889-2]
DR Ensembl; ENST00000292125.6; ENSP00000292125.2; ENSG00000170848.16. [Q00889-1]
DR GeneID; 5675; -.
DR KEGG; hsa:5675; -.
DR MANE-Select; ENST00000187910.7; ENSP00000187910.3; NM_001031850.4; NP_001027020.1. [Q00889-2]
DR UCSC; uc002ovg.3; human. [Q00889-1]
DR CTD; 5675; -.
DR DisGeNET; 5675; -.
DR GeneCards; PSG6; -.
DR HGNC; HGNC:9523; PSG6.
DR HPA; ENSG00000170848; Tissue enriched (placenta).
DR MIM; 176395; gene.
DR MIM; 176399; gene.
DR neXtProt; NX_Q00889; -.
DR OpenTargets; ENSG00000170848; -.
DR PharmGKB; PA33868; -.
DR VEuPathDB; HostDB:ENSG00000170848; -.
DR eggNOG; ENOG502RXPD; Eukaryota.
DR GeneTree; ENSGT00960000186634; -.
DR HOGENOM; CLU_024555_2_0_1; -.
DR InParanoid; Q00889; -.
DR OMA; NYRINTS; -.
DR OrthoDB; 998214at2759; -.
DR PhylomeDB; Q00889; -.
DR TreeFam; TF336859; -.
DR PathwayCommons; Q00889; -.
DR Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR SignaLink; Q00889; -.
DR BioGRID-ORCS; 5675; 25 hits in 982 CRISPR screens.
DR ChiTaRS; PSG6; human.
DR GeneWiki; PSG6; -.
DR GenomeRNAi; 5675; -.
DR Pharos; Q00889; Tbio.
DR PRO; PR:Q00889; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q00889; protein.
DR Bgee; ENSG00000170848; Expressed in placenta and 27 other tissues.
DR ExpressionAtlas; Q00889; baseline and differential.
DR Genevisible; Q00889; HS.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:1990782; F:protein tyrosine kinase binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; TAS:ProtInc.
DR GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 4.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF13895; Ig_2; 2.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; SSF48726; 4.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..435
FT /note="Pregnancy-specific beta-1-glycoprotein 6"
FT /id="PRO_0000014913"
FT DOMAIN 35..143
FT /note="Ig-like V-type"
FT DOMAIN 148..233
FT /note="Ig-like C2-type 1"
FT DOMAIN 241..326
FT /note="Ig-like C2-type 2"
FT DOMAIN 334..405
FT /note="Ig-like C2-type 3"
FT MOTIF 126..128
FT /note="Cell attachment site"
FT /evidence="ECO:0000255"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 302
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 386
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 168..216
FT /evidence="ECO:0000305"
FT DISULFID 261..309
FT /evidence="ECO:0000305"
FT DISULFID 353..393
FT /evidence="ECO:0000305"
FT VAR_SEQ 414..435
FT /note="ETASPQVTYAGPNTWFQEILLL -> GPCHGNQTESH (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:2271648, ECO:0000303|PubMed:2346748"
FT /id="VSP_039344"
FT VARIANT 85
FT /note="H -> D (in dbSNP:rs3198831)"
FT /evidence="ECO:0000269|PubMed:2271648,
FT ECO:0000269|PubMed:2346748"
FT /id="VAR_049922"
FT VARIANT 155
FT /note="L -> F (in dbSNP:rs1058674)"
FT /id="VAR_011723"
FT VARIANT 161
FT /note="M -> T (in dbSNP:rs1058679)"
FT /id="VAR_049923"
FT VARIANT 165
FT /note="R -> L (in dbSNP:rs1058680)"
FT /id="VAR_011724"
FT VARIANT 167
FT /note="I -> T (in dbSNP:rs1065505)"
FT /id="VAR_011725"
FT VARIANT 180
FT /note="L -> W (in dbSNP:rs1065507)"
FT /id="VAR_011726"
FT VARIANT 181
FT /note="L -> M (in dbSNP:rs1065508)"
FT /id="VAR_011727"
FT VARIANT 185
FT /note="N -> S (in dbSNP:rs1065509)"
FT /id="VAR_011728"
FT VARIANT 188
FT /note="M -> R (in dbSNP:rs59587483)"
FT /id="VAR_061324"
FT VARIANT 191
FT /note="R -> S (in dbSNP:rs1058688)"
FT /id="VAR_011729"
FT VARIANT 196
FT /note="K -> E (in dbSNP:rs1065511)"
FT /id="VAR_011730"
FT VARIANT 253
FT /note="K -> N (in dbSNP:rs1065513)"
FT /id="VAR_011731"
FT VARIANT 257
FT /note="L -> S (in dbSNP:rs1058710)"
FT /id="VAR_011732"
FT VARIANT 258
FT /note="A -> T (in dbSNP:rs1065515)"
FT /id="VAR_011733"
FT VARIANT 404
FT /note="I -> S (in dbSNP:rs1065525)"
FT /id="VAR_011735"
FT CONFLICT 41
FT /note="K -> Q (in Ref. 3; CAA34957)"
FT /evidence="ECO:0000305"
FT CONFLICT 148
FT /note="P -> R (in Ref. 3; CAA34957)"
FT /evidence="ECO:0000305"
FT CONFLICT 220..221
FT /note="NP -> RG (in Ref. 3; CAA34957)"
FT /evidence="ECO:0000305"
FT CONFLICT 339
FT /note="S -> Y (in Ref. 3; CAA34957)"
FT /evidence="ECO:0000305"
FT CONFLICT 364
FT /note="S -> F (in Ref. 2; AAA36512 and 3; CAA34957)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 435 AA; 48814 MW; D94D4B0884327C60 CRC64;
MGPLSAPPCT QHITWKGLLL TASLLNFWNL PTTAQVIIEA KPPKVSEGKD VLLLVHNLPQ
NLTGYIWYKG QMTDLYHYIT SYVVHGQIIY GPAYSGRETV YSNASLLIQN VTQEDAGSYT
LHIIKRGDGT GGVTGYFTVT LYSETPKPSI SSSNLNPREV MEAVRLICDP ETPDASYLWL
LNGQNLPMTH RLQLSKTNRT LYLFGVTKYI AGPYECEIRN PVSASRSDPV TLNLLPKLPM
PYITINNLNP REKKDVLAFT CEPKSRNYTY IWWLNGQSLP VSPRVKRPIE NRILILPSVT
RNETGPYQCE IRDRYGGIRS NPVTLNVLYG PDLPRIYPSF TYYRSGENLD LSCFADSNPP
AEYSWTINGK FQLSGQKLFI PQITTNHSGL YACSVRNSAT GKEISKSMIV KVSETASPQV
TYAGPNTWFQ EILLL
