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PSG7_HUMAN
ID   PSG7_HUMAN              Reviewed;         419 AA.
AC   Q13046; A0A087WSZ1; Q15232;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 3.
DT   03-AUG-2022, entry version 165.
DE   RecName: Full=Putative pregnancy-specific beta-1-glycoprotein 7;
DE            Short=PS-beta-G-7;
DE            Short=PSBG-7;
DE            Short=Pregnancy-specific glycoprotein 7;
DE   Flags: Precursor;
GN   Name=PSG7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=7794280; DOI=10.1006/bbrc.1995.1862;
RA   Teglund S., Zhou G.Q., Hammarstroem S.;
RT   "Characterization of cDNA encoding novel pregnancy-specific glycoprotein
RT   variants.";
RL   Biochem. Biophys. Res. Commun. 211:656-664(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 233-414.
RX   PubMed=1690992; DOI=10.1016/0006-291x(90)92103-7;
RA   Thompson J., Koumari R., Wagner K., Barnert S., Schleussner C., Schrewe H.,
RA   Zimmermann W., Mueller G., Schempp W., Zaninetta D., Ammaturo D.,
RA   Hardman N.;
RT   "The human pregnancy-specific glycoprotein genes are tightly linked on the
RT   long arm of chromosome 19 and are coordinately expressed.";
RL   Biochem. Biophys. Res. Commun. 167:848-859(1990).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: PSBG are produced in high quantity during
CC       pregnancy.
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; U18467; AAA75293.1; -; mRNA.
DR   EMBL; AC005260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF454892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M32619; AAA60200.1; -; Genomic_DNA.
DR   EMBL; M32617; AAA60200.1; JOINED; Genomic_DNA.
DR   EMBL; M32618; AAA60200.1; JOINED; Genomic_DNA.
DR   PIR; I83053; I83053.
DR   PIR; JC4123; JC4123.
DR   RefSeq; NP_002774.2; NM_002783.2.
DR   AlphaFoldDB; Q13046; -.
DR   SMR; Q13046; -.
DR   STRING; 9606.ENSP00000421986; -.
DR   GlyGen; Q13046; 7 sites.
DR   iPTMnet; Q13046; -.
DR   PhosphoSitePlus; Q13046; -.
DR   BioMuta; PSG7; -.
DR   DMDM; 108935881; -.
DR   MassIVE; Q13046; -.
DR   PeptideAtlas; Q13046; -.
DR   PRIDE; Q13046; -.
DR   ProteomicsDB; 59122; -.
DR   Antibodypedia; 21551; 46 antibodies from 8 providers.
DR   DNASU; 5676; -.
DR   Ensembl; ENST00000406070.7; ENSP00000421986.1; ENSG00000221878.13.
DR   GeneID; 5676; -.
DR   KEGG; hsa:5676; -.
DR   MANE-Select; ENST00000406070.7; ENSP00000421986.1; NM_002783.3; NP_002774.2.
DR   CTD; 5676; -.
DR   DisGeNET; 5676; -.
DR   GeneCards; PSG7; -.
DR   HGNC; HGNC:9524; PSG7.
DR   HPA; ENSG00000221878; Group enriched (placenta, skin).
DR   MIM; 176396; gene.
DR   neXtProt; NX_Q13046; -.
DR   OpenTargets; ENSG00000221878; -.
DR   PharmGKB; PA33869; -.
DR   VEuPathDB; HostDB:ENSG00000221878; -.
DR   eggNOG; ENOG502RXPD; Eukaryota.
DR   GeneTree; ENSGT00960000186634; -.
DR   InParanoid; Q13046; -.
DR   OrthoDB; 998214at2759; -.
DR   PathwayCommons; Q13046; -.
DR   Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR   BioGRID-ORCS; 5676; 5 hits in 146 CRISPR screens.
DR   ChiTaRS; PSG7; human.
DR   GenomeRNAi; 5676; -.
DR   Pharos; Q13046; Tdark.
DR   PRO; PR:Q13046; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q13046; protein.
DR   Bgee; ENSG00000221878; Expressed in placenta and 44 other tissues.
DR   ExpressionAtlas; Q13046; baseline and differential.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:1990782; F:protein tyrosine kinase binding; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; TAS:ProtInc.
DR   GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 4.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF13895; Ig_2; 2.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 4.
DR   SMART; SM00408; IGc2; 3.
DR   SUPFAM; SSF48726; SSF48726; 4.
DR   PROSITE; PS50835; IG_LIKE; 3.
PE   5: Uncertain;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome;
KW   Repeat; Secreted; Signal.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000255"
FT   CHAIN           35..419
FT                   /note="Putative pregnancy-specific beta-1-glycoprotein 7"
FT                   /id="PRO_0000014914"
FT   DOMAIN          35..144
FT                   /note="Ig-like V-type"
FT   DOMAIN          147..234
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          240..327
FT                   /note="Ig-like C2-type 2"
FT   DOMAIN          335..410
FT                   /note="Ig-like C2-type 3"
FT   MOTIF           127..129
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        61
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        104
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        111
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        199
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        209
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        268
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        303
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        169..217
FT                   /evidence="ECO:0000305"
FT   DISULFID        262..310
FT                   /evidence="ECO:0000305"
FT   DISULFID        354..394
FT                   /evidence="ECO:0000305"
FT   VARIANT         65
FT                   /note="Y -> H (in dbSNP:rs7245978)"
FT                   /id="VAR_056075"
FT   CONFLICT        83
FT                   /note="I -> V (in Ref. 1; AAA75293)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        233..237
FT                   /note="LNLLP -> IIVPV (in Ref. 3; AAA60200)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        348
FT                   /note="Q -> E (in Ref. 3; AAA60200)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   419 AA;  47027 MW;  57219C6FB683BF33 CRC64;
     MGPLSAPPCT QHITWKGLLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD VLLLVHNLPQ
     NLTGYIWYKG QIRDLYHYVT SYIVDGQIIK YGPAYSGRET VYSNASLLIQ NVTQEDTGSY
     TLHIIKRGDG TGGVTGRFTF TLYLETPKPS ISSSNFNPRE ATEAVILTCD PETPDASYLW
     WMNGQSLPMT HSLQLSETNR TLYLFGVTNY TAGPYECEIR NPVSASRSDP VTLNLLPKLP
     KPYITINNLN PRENKDVSTF TCEPKSENYT YIWWLNGQSL PVSPRVKRRI ENRILILPSV
     TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYHSGQNL YLSCFADSNP
     PAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA TGKESSKSVT VRVSDWTLP
 
 
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