PSG8_HUMAN
ID PSG8_HUMAN Reviewed; 426 AA.
AC Q9UQ74; A5PKV3; B2RPL4; B4DTI6; O60410; Q68CR6;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 2.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Pregnancy-specific beta-1-glycoprotein 8;
DE Short=PS-beta-G-8;
DE Short=PSBG-8;
DE Short=Pregnancy-specific glycoprotein 8;
DE Flags: Precursor;
GN Name=PSG8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-144 (ISOFORM 1).
RX PubMed=10686536; DOI=10.1159/000030112;
RA Fraengsmyr L., Israelsson A., Teglund S., Matsunaga T., Hammarstroem S.;
RT "Evolution of the carcinoembryonic antigen family. structures of CGM9,
RT CGM11 and pregnancy-specific glycoprotein promoters.";
RL Tumor Biol. 21:63-81(2000).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9UQ74-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UQ74-2; Sequence=VSP_041096, VSP_041097;
CC Name=3;
CC IsoId=Q9UQ74-3; Sequence=VSP_041097;
CC -!- DEVELOPMENTAL STAGE: PSBG are produced in high quantity during
CC pregnancy.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC {ECO:0000305}.
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DR EMBL; AK300230; BAG61998.1; -; mRNA.
DR EMBL; CR749812; CAH18672.1; -; mRNA.
DR EMBL; AC004654; AAC15514.1; -; Genomic_DNA.
DR EMBL; BC137500; AAI37501.1; -; mRNA.
DR EMBL; BC142628; AAI42629.1; -; mRNA.
DR EMBL; AH007519; AAD21022.1; -; Genomic_DNA.
DR CCDS; CCDS33037.1; -. [Q9UQ74-1]
DR CCDS; CCDS46090.1; -. [Q9UQ74-2]
DR CCDS; CCDS46091.1; -. [Q9UQ74-3]
DR PIR; A28928; A28928.
DR RefSeq; NP_001123639.1; NM_001130167.1. [Q9UQ74-3]
DR RefSeq; NP_001123640.1; NM_001130168.1. [Q9UQ74-2]
DR RefSeq; NP_874366.1; NM_182707.2. [Q9UQ74-1]
DR AlphaFoldDB; Q9UQ74; -.
DR SMR; Q9UQ74; -.
DR BioGRID; 136660; 43.
DR IntAct; Q9UQ74; 37.
DR STRING; 9606.ENSP00000305005; -.
DR GlyGen; Q9UQ74; 6 sites.
DR iPTMnet; Q9UQ74; -.
DR PhosphoSitePlus; Q9UQ74; -.
DR BioMuta; PSG8; -.
DR DMDM; 47117919; -.
DR MassIVE; Q9UQ74; -.
DR PaxDb; Q9UQ74; -.
DR PeptideAtlas; Q9UQ74; -.
DR PRIDE; Q9UQ74; -.
DR ProteomicsDB; 85514; -. [Q9UQ74-1]
DR ProteomicsDB; 85515; -. [Q9UQ74-2]
DR ProteomicsDB; 85516; -. [Q9UQ74-3]
DR Antibodypedia; 66802; 9 antibodies from 5 providers.
DR DNASU; 440533; -.
DR Ensembl; ENST00000306511.5; ENSP00000305005.4; ENSG00000124467.19. [Q9UQ74-1]
DR Ensembl; ENST00000404209.8; ENSP00000385869.3; ENSG00000124467.19. [Q9UQ74-3]
DR Ensembl; ENST00000406636.7; ENSP00000385081.3; ENSG00000124467.19. [Q9UQ74-2]
DR GeneID; 440533; -.
DR KEGG; hsa:440533; -.
DR MANE-Select; ENST00000306511.5; ENSP00000305005.4; NM_182707.3; NP_874366.1.
DR UCSC; uc002ouh.4; human. [Q9UQ74-1]
DR CTD; 440533; -.
DR DisGeNET; 440533; -.
DR GeneCards; PSG8; -.
DR HGNC; HGNC:9525; PSG8.
DR HPA; ENSG00000124467; Tissue enriched (placenta).
DR MIM; 176397; gene.
DR neXtProt; NX_Q9UQ74; -.
DR OpenTargets; ENSG00000124467; -.
DR PharmGKB; PA33870; -.
DR VEuPathDB; HostDB:ENSG00000124467; -.
DR eggNOG; ENOG502RXPD; Eukaryota.
DR GeneTree; ENSGT00960000186634; -.
DR HOGENOM; CLU_024555_2_0_1; -.
DR InParanoid; Q9UQ74; -.
DR OMA; ENNRILM; -.
DR OrthoDB; 998214at2759; -.
DR PhylomeDB; Q9UQ74; -.
DR TreeFam; TF336859; -.
DR PathwayCommons; Q9UQ74; -.
DR Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR SignaLink; Q9UQ74; -.
DR BioGRID-ORCS; 440533; 66 hits in 987 CRISPR screens.
DR GenomeRNAi; 440533; -.
DR Pharos; Q9UQ74; Tdark.
DR PRO; PR:Q9UQ74; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9UQ74; protein.
DR Bgee; ENSG00000124467; Expressed in placenta and 27 other tissues.
DR ExpressionAtlas; Q9UQ74; baseline and differential.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:1990782; F:protein tyrosine kinase binding; IBA:GO_Central.
DR GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 4.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; SSF48726; 4.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..426
FT /note="Pregnancy-specific beta-1-glycoprotein 8"
FT /id="PRO_0000014915"
FT DOMAIN 35..144
FT /note="Ig-like V-type"
FT DOMAIN 147..234
FT /note="Ig-like C2-type 1"
FT DOMAIN 240..327
FT /note="Ig-like C2-type 2"
FT DOMAIN 335..410
FT /note="Ig-like C2-type 3"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 199
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 268
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 303
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 169..217
FT /evidence="ECO:0000305"
FT DISULFID 262..310
FT /evidence="ECO:0000305"
FT DISULFID 354..394
FT /evidence="ECO:0000305"
FT VAR_SEQ 22..144
FT /note="ASLLNFWNPPTTAQVTIEAQPTKVSEGKDVLLLVHNLPQNLTGYIWYKGQIR
FT DLYHYITSYVVDGQIIIYGPAYSGRETIYSNASLLIQNVTQEDAGSYTLHIIMGGDENR
FT GVTGHFTFTLYL -> V (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_041096"
FT VAR_SEQ 415..426
FT /note="GKRIPVSLAIGI -> DWTLP (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:17974005"
FT /id="VSP_041097"
FT VARIANT 315
FT /note="Q -> P (in dbSNP:rs11879884)"
FT /id="VAR_049924"
FT VARIANT 349
FT /note="V -> D (in dbSNP:rs1064490)"
FT /id="VAR_033620"
FT CONFLICT 10..12
FT /note="TQR -> MQH (in Ref. 2; CAH18672)"
FT /evidence="ECO:0000305"
FT CONFLICT 79
FT /note="I -> T (in Ref. 2; CAH18672)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="S -> I (in Ref. 1; BAG61998)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 426 AA; 47772 MW; C81C9E026BEC0D59 CRC64;
MGLLSAPPCT QRITWKGLLL TASLLNFWNP PTTAQVTIEA QPTKVSEGKD VLLLVHNLPQ
NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET IYSNASLLIQ NVTQEDAGSY
TLHIIMGGDE NRGVTGHFTF TLYLETPKPS ISSSKLNPRE AMEAVSLTCD PETPDASYLW
WMNGQSLPMS HRLQLSETNR TLFLLGVTKY TAGPYECEIR NPVSASRSDP FTLNLLPKLP
KPYITINNLK PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV
TRNETGPYQC EIRDQYGGIR SYPVTLNVLY GPDLPRIYPS FTYYRSGEVL YLSCSADSNP
PAQYSWTING KFQLSGQKLF IPQITTKHSG LYACSVRNSA TGKESSKSMT VKVSGKRIPV
SLAIGI
