PSG9_HUMAN
ID PSG9_HUMAN Reviewed; 426 AA.
AC Q00887; B2R869; Q15227; Q15236; Q15237; Q8WW78; Q9UQ73;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1999, sequence version 2.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=Pregnancy-specific beta-1-glycoprotein 9;
DE Short=PS-beta-G-9;
DE Short=PSBG-9;
DE Short=Pregnancy-specific glycoprotein 9;
DE AltName: Full=PS34;
DE AltName: Full=Pregnancy-specific beta-1 glycoprotein B;
DE Short=PS-beta-B;
DE AltName: Full=Pregnancy-specific beta-1-glycoprotein 11;
DE Short=PS-beta-G-11;
DE Short=PSBG-11;
DE Short=Pregnancy-specific glycoprotein 11;
DE AltName: Full=Pregnancy-specific glycoprotein 7;
DE Short=PSG7;
DE Flags: Precursor;
GN Name=PSG9; Synonyms=PSG11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=2322584; DOI=10.1016/0167-4781(90)90072-a;
RA Arakawa F., Kuroki M., Misumi Y., Matsuo Y., Matsuoka Y.;
RT "The nucleotide and deduced amino acid sequences of a cDNA encoding a new
RT species of pregnancy-specific beta 1-glycoprotein (PS beta G).";
RL Biochim. Biophys. Acta 1048:303-305(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=2341148; DOI=10.1016/0888-7543(90)90492-d;
RA Streydio C., Swillens S., Georges M., Szpirer C., Vassart G.;
RT "Structure, evolution and chromosomal localization of the human pregnancy-
RT specific beta 1 glycoprotein gene family.";
RL Genomics 6:579-592(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Fetal liver;
RX PubMed=2328001; DOI=10.1016/0006-291x(90)91696-p;
RA Khan W.N., Hammarstroem S.;
RT "Identification of a new carcinoembryonic antigen (CEA) family member in
RT human fetal liver -- cloning and sequence determination of pregnancy-
RT specific glycoprotein 7.";
RL Biochem. Biophys. Res. Commun. 168:214-225(1990).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Placenta;
RX PubMed=1922019; DOI=10.1007/bf00230182;
RA Chan W.Y., Zheng Q.X., McMahon J., Tease L.A.;
RT "Characterization of new members of the pregnancy-specific beta 1-
RT glycoprotein family.";
RL Mol. Cell. Biochem. 106:161-170(1991).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=1581354; DOI=10.1016/0167-4781(92)90110-l;
RA Brophy B.K., MacDonald R.E., McLenachan P.A., Mansfield B.C.;
RT "cDNA sequence of the pregnancy-specific beta 1-glycoprotein-11s (PSG-
RT 11s).";
RL Biochim. Biophys. Acta 1131:119-121(1992).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [10]
RP NUCLEOTIDE SEQUENCE OF 1-143.
RA Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.;
RT "Characterization of upstream promotor region, exon1 and exon2 of the PSG
RT gene family.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [11]
RP NUCLEOTIDE SEQUENCE OF 23-143.
RC TISSUE=Peripheral blood;
RA Beggs K.T., McLenachan T., Mansfield B.;
RL Submitted (AUG-1991) to the EMBL/GenBank/DDBJ databases.
RN [12]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 416-426.
RX PubMed=7806221; DOI=10.1006/geno.1994.1395;
RA McLenachan P.A., Rutherfurd K.J., Beggs K.T., Sims S.E., Mansfield B.C.;
RT "Characterization of the PSG11 gene.";
RL Genomics 22:356-363(1994).
RN [13]
RP FUNCTION, AND INTERACTION WITH LATENCY-ASSOCIATED PEPTIDE.
RX PubMed=27389696; DOI=10.1371/journal.pone.0158050;
RA Jones K., Ballesteros A., Mentink-Kane M., Warren J., Rattila S.,
RA Malech H., Kang E., Dveksler G.;
RT "PSG9 Stimulates Increase in FoxP3+ Regulatory T-Cells through the TGF-
RT beta1 Pathway.";
RL PLoS ONE 11:e0158050-e0158050(2016).
CC -!- FUNCTION: Binds to the small latent transforming growth factor-beta
CC complex, consisting of the N-terminal TGFB1 latency-associated peptide
CC (LAP) and the mature form of TGFB1, thereby leading to the activation
CC of TGFB1 (PubMed:27389696). The activation of TGFB1 leads to
CC stimulation of naive CD4(+) T-cells to increase FoxP3 expression and to
CC an increase in the number of FoxP3(+) regulatory T-cells
CC (PubMed:27389696). Induces the differentiation of a suppressive
CC CD4(+)LAP(+)FoxP3(-) T-cell subset (PubMed:27389696). Induces the
CC secretion of TGFB1 in macrophages, but not in activated CD4(+) T-cells
CC (PubMed:27389696). May reduce the expression of several pro-
CC inflammatory cytokines and chemokines by CD4(+) T-cells, including IL2
CC and IL6 (PubMed:27389696). {ECO:0000269|PubMed:27389696}.
CC -!- SUBUNIT: Interacts with latency-associated peptide; leading to TGFB1
CC activation. {ECO:0000269|PubMed:27389696}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q00887-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q00887-2; Sequence=VSP_055602, VSP_055603;
CC -!- DEVELOPMENTAL STAGE: PSBG are produced in high quantity during
CC pregnancy.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC {ECO:0000305}.
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DR EMBL; X17610; CAA35612.1; -; mRNA.
DR EMBL; M34421; AAA52605.1; -; mRNA.
DR EMBL; M34481; AAA74512.1; -; mRNA.
DR EMBL; M38046; AAA63251.1; -; mRNA.
DR EMBL; M94890; AAA60194.1; -; mRNA.
DR EMBL; M58591; AAA60203.1; -; mRNA.
DR EMBL; AK313256; BAG36066.1; -; mRNA.
DR EMBL; AC005392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471126; EAW57180.1; -; Genomic_DNA.
DR EMBL; CH471126; EAW57183.1; -; Genomic_DNA.
DR EMBL; BC020759; AAH20759.1; -; mRNA.
DR EMBL; AH007520; AAD21023.1; -; Genomic_DNA.
DR EMBL; M38243; AAA63252.1; -; Genomic_DNA.
DR EMBL; U04325; AAA78266.1; -; Genomic_DNA.
DR CCDS; CCDS12618.1; -. [Q00887-1]
DR PIR; B35334; B35334.
DR PIR; C55181; C55181.
DR PIR; S09016; S09016.
DR RefSeq; NP_001288636.1; NM_001301707.1.
DR RefSeq; NP_001288637.1; NM_001301708.1.
DR RefSeq; NP_001288638.1; NM_001301709.1.
DR RefSeq; NP_002775.3; NM_002784.4. [Q00887-1]
DR RefSeq; XP_005259132.1; XM_005259075.3. [Q00887-2]
DR AlphaFoldDB; Q00887; -.
DR BioGRID; 111652; 29.
DR IntAct; Q00887; 20.
DR MINT; Q00887; -.
DR STRING; 9606.ENSP00000270077; -.
DR GlyGen; Q00887; 6 sites.
DR iPTMnet; Q00887; -.
DR PhosphoSitePlus; Q00887; -.
DR BioMuta; PSG9; -.
DR DMDM; 6093845; -.
DR jPOST; Q00887; -.
DR MassIVE; Q00887; -.
DR PaxDb; Q00887; -.
DR PeptideAtlas; Q00887; -.
DR PRIDE; Q00887; -.
DR ProteomicsDB; 57879; -. [Q00887-1]
DR ProteomicsDB; 60493; -.
DR Antibodypedia; 17573; 186 antibodies from 19 providers.
DR DNASU; 5678; -.
DR Ensembl; ENST00000244293.11; ENSP00000244293.7; ENSG00000183668.18. [Q00887-2]
DR Ensembl; ENST00000270077.8; ENSP00000270077.3; ENSG00000183668.18. [Q00887-1]
DR GeneID; 5678; -.
DR KEGG; hsa:5678; -.
DR MANE-Select; ENST00000270077.8; ENSP00000270077.3; NM_002784.5; NP_002775.3.
DR UCSC; uc002owd.5; human. [Q00887-1]
DR CTD; 5678; -.
DR DisGeNET; 5678; -.
DR GeneCards; PSG9; -.
DR HGNC; HGNC:9526; PSG9.
DR HPA; ENSG00000183668; Tissue enriched (placenta).
DR MIM; 176398; gene.
DR neXtProt; NX_Q00887; -.
DR OpenTargets; ENSG00000183668; -.
DR PharmGKB; PA33871; -.
DR VEuPathDB; HostDB:ENSG00000183668; -.
DR eggNOG; ENOG502RXPD; Eukaryota.
DR GeneTree; ENSGT00960000186634; -.
DR InParanoid; Q00887; -.
DR OrthoDB; 998214at2759; -.
DR PhylomeDB; Q00887; -.
DR TreeFam; TF336859; -.
DR PathwayCommons; Q00887; -.
DR Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR SignaLink; Q00887; -.
DR BioGRID-ORCS; 5678; 7 hits in 989 CRISPR screens.
DR ChiTaRS; PSG9; human.
DR GeneWiki; PSG9; -.
DR GenomeRNAi; 5678; -.
DR Pharos; Q00887; Tbio.
DR PRO; PR:Q00887; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q00887; protein.
DR Bgee; ENSG00000183668; Expressed in placenta and 42 other tissues.
DR ExpressionAtlas; Q00887; baseline and differential.
DR Genevisible; Q00887; HS.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0070021; C:transforming growth factor beta ligand-receptor complex; IDA:UniProtKB.
DR GO; GO:1990782; F:protein tyrosine kinase binding; IBA:GO_Central.
DR GO; GO:0044877; F:protein-containing complex binding; IDA:UniProtKB.
DR GO; GO:0002774; P:Fc receptor mediated inhibitory signaling pathway; IDA:UniProtKB.
DR GO; GO:0007565; P:female pregnancy; TAS:UniProtKB.
DR GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; IDA:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
DR GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central.
DR GO; GO:0045589; P:regulation of regulatory T cell differentiation; IDA:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR GO; GO:0002461; P:tolerance induction dependent upon immune response; IDA:UniProtKB.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0036364; P:transforming growth factor beta1 activation; IDA:UniProtKB.
DR Gene3D; 2.60.40.10; -; 4.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; SSF48726; 4.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..426
FT /note="Pregnancy-specific beta-1-glycoprotein 9"
FT /id="PRO_0000014916"
FT DOMAIN 35..144
FT /note="Ig-like V-type"
FT DOMAIN 147..234
FT /note="Ig-like C2-type 1"
FT DOMAIN 242..326
FT /note="Ig-like C2-type 2"
FT DOMAIN 335..410
FT /note="Ig-like C2-type 3"
FT MOTIF 127..129
FT /note="Cell attachment site"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 199
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 268
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 303
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 387
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 169..217
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 262..310
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 354..394
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 237..330
FT /note="PKLPIPYITINNLNPRENKDVLAFTCEPKSENYTYIWWLNGQSLPVSPGVKR
FT PIENRILILPSVTRNETGPYQCEIRDRYGGLRSNPVILNVLY -> H (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:1922019"
FT /id="VSP_055602"
FT VAR_SEQ 416..426
FT /note="PCHGDLTESQS -> KWIPASLAVGFYVESIWLSEKSQENIFIPSLCPMGTS
FT KSQILLLNPPNLSLQTLFSLFFCFLMADLVSGLKKVGRGLYQP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:1922019"
FT /id="VSP_055603"
FT VARIANT 18
FT /note="L -> V (in dbSNP:rs8101191)"
FT /id="VAR_059410"
FT VARIANT 176
FT /note="A -> T (in dbSNP:rs763005161)"
FT /id="VAR_058296"
FT VARIANT 325
FT /note="I -> T (in dbSNP:rs1135905)"
FT /id="VAR_049925"
FT VARIANT 374
FT /note="Q -> L (in dbSNP:rs2074923)"
FT /id="VAR_049926"
FT VARIANT 397
FT /note="H -> R (in dbSNP:rs2072285)"
FT /id="VAR_049927"
FT CONFLICT 4
FT /note="L -> F (in Ref. 5; AAA60203)"
FT /evidence="ECO:0000305"
FT CONFLICT 49
FT /note="K -> Q (in Ref. 5; AAA63251)"
FT /evidence="ECO:0000305"
FT CONFLICT 203
FT /note="Y -> C (in Ref. 1; CAA35612)"
FT /evidence="ECO:0000305"
FT CONFLICT 226
FT /note="S -> I (in Ref. 5; AAA60203)"
FT /evidence="ECO:0000305"
FT CONFLICT 313
FT /note="R -> Q (in Ref. 9; AAH20759)"
FT /evidence="ECO:0000305"
FT CONFLICT 349
FT /note="N -> I (in Ref. 5; AAA63251)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 426 AA; 48272 MW; 69F72CF4B608BA39 CRC64;
MGPLPAPSCT QRITWKGLLL TASLLNFWNP PTTAEVTIEA QPPKVSEGKD VLLLVHNLPQ
NLPGYFWYKG EMTDLYHYII SYIVDGKIII YGPAYSGRET VYSNASLLIQ NVTRKDAGTY
TLHIIKRGDE TREEIRHFTF TLYLETPKPY ISSSNLNPRE AMEAVRLICD PETLDASYLW
WMNGQSLPVT HRLQLSKTNR TLYLFGVTKY IAGPYECEIR NPVSASRSDP VTLNLLPKLP
IPYITINNLN PRENKDVLAF TCEPKSENYT YIWWLNGQSL PVSPGVKRPI ENRILILPSV
TRNETGPYQC EIRDRYGGLR SNPVILNVLY GPDLPRIYPS FTYYRSGENL DLSCFTESNP
PAEYFWTING KFQQSGQKLF IPQITRNHSG LYACSVHNSA TGKEISKSMT VKVSGPCHGD
LTESQS
