ID   PSMA2_STAAE             Reviewed;          21 AA.
AC   P0C7Z7; B9ZUX6;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Phenol-soluble modulin alpha 2 peptide;
GN   Name=psmA2; OrderedLocusNames=NWMN_0417.3; ORFNames=NWMN_2618;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
CC   -!- FUNCTION: Peptide which can recruit, activate and subsequently lyse
CC       human neutrophils, thus eliminating the main cellular defense against
CC       infection. {ECO:0000250|UniProtKB:A9JX06}.
CC   -!- SIMILARITY: Belongs to the phenol-soluble modulin alpha peptides
CC       family. {ECO:0000305}.
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DR   EMBL; AP009351; BAH22634.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0C7Z7; -.
DR   EnsemblBacteria; BAH22634; BAH22634; NWMN_2618.
DR   KEGG; sae:NWMN_2618; -.
DR   HOGENOM; CLU_222042_0_0_9; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR031429; PSM_alpha.
DR   Pfam; PF17063; PSMalpha; 1.
PE   3: Inferred from homology;
KW   Cytolysis; Virulence.
FT   PEPTIDE         1..21
FT                   /note="Phenol-soluble modulin alpha 2 peptide"
FT                   /id="PRO_0000345050"
SQ   SEQUENCE   21 AA;  2278 MW;  E3D5498D1727572D CRC64;
     MGIIAGIIKF IKGLIEKFTG K