PSMA2_STAAM
ID PSMA2_STAAM Reviewed; 21 AA.
AC P0C7Z8;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 25-MAY-2022, entry version 23.
DE RecName: Full=Phenol-soluble modulin alpha 2 peptide;
GN Name=psmA2; OrderedLocusNames=SAV0451.3;
OS Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=158878;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu50 / ATCC 700699;
RX PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL Lancet 357:1225-1240(2001).
CC -!- FUNCTION: Peptide which can recruit, activate and subsequently lyse
CC human neutrophils, thus eliminating the main cellular defense against
CC infection. {ECO:0000250|UniProtKB:A9JX06}.
CC -!- SIMILARITY: Belongs to the phenol-soluble modulin alpha peptides
CC family. {ECO:0000305}.
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DR EMBL; BA000017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P0C7Z8; -.
DR Proteomes; UP000002481; Chromosome.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR InterPro; IPR031429; PSM_alpha.
DR Pfam; PF17063; PSMalpha; 1.
PE 3: Inferred from homology;
KW Cytolysis; Virulence.
FT PEPTIDE 1..21
FT /note="Phenol-soluble modulin alpha 2 peptide"
FT /id="PRO_0000345051"
SQ SEQUENCE 21 AA; 2278 MW; E3D5498D1727572D CRC64;
MGIIAGIIKF IKGLIEKFTG K