ID   PSMA3_STAA1             Reviewed;          22 AA.
AC   P0C802;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Phenol-soluble modulin alpha 3 peptide;
GN   Name=psmA3; OrderedLocusNames=SAHV_0449.2;
OS   Staphylococcus aureus (strain Mu3 / ATCC 700698).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=418127;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu3 / ATCC 700698;
RX   PubMed=17954695; DOI=10.1128/aac.00534-07;
RA   Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K.;
RT   "Mutated response regulator graR is responsible for phenotypic conversion
RT   of Staphylococcus aureus from heterogeneous vancomycin-intermediate
RT   resistance to vancomycin-intermediate resistance.";
RL   Antimicrob. Agents Chemother. 52:45-53(2008).
CC   -!- FUNCTION: Peptide which can recruit, activate and subsequently lyse
CC       human neutrophils, thus eliminating the main cellular defense against
CC       infection. {ECO:0000250|UniProtKB:A9JX07}.
CC   -!- SIMILARITY: Belongs to the phenol-soluble modulin alpha peptides
CC       family. {ECO:0000305}.
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DR   EMBL; AP009324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; WP_014373779.1; NZ_CTYB01000045.1.
DR   AlphaFoldDB; P0C802; -.
DR   SMR; P0C802; -.
DR   GeneID; 66840985; -.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR031429; PSM_alpha.
DR   Pfam; PF17063; PSMalpha; 1.
PE   3: Inferred from homology;
KW   Cytolysis; Virulence.
FT   PEPTIDE         1..22
FT                   /note="Phenol-soluble modulin alpha 3 peptide"
FT                   /id="PRO_0000345057"
SQ   SEQUENCE   22 AA;  2607 MW;  66313C34F671C8C7 CRC64;
     MEFVAKLFKF FKDLLGKFLG NN