ID   PSMA3_STAA8             Reviewed;          22 AA.
AC   P0C805;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Phenol-soluble modulin alpha 3 peptide;
GN   Name=psmA3; OrderedLocusNames=SAOUHSC_00411.2;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- FUNCTION: Peptide which can recruit, activate and subsequently lyse
CC       human neutrophils, thus eliminating the main cellular defense against
CC       infection. {ECO:0000250|UniProtKB:A9JX07}.
CC   -!- SIMILARITY: Belongs to the phenol-soluble modulin alpha peptides
CC       family. {ECO:0000305}.
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DR   EMBL; CP000253; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; WP_014373779.1; NZ_LS483365.1.
DR   PDB; 5I55; X-ray; 1.45 A; A=1-22.
DR   PDB; 5KGY; NMR; -; A=2-22.
DR   PDB; 6GQ2; X-ray; 1.54 A; A=1-22.
DR   PDB; 6GQ5; X-ray; 1.50 A; A=1-22.
DR   PDB; 6GQC; X-ray; 1.40 A; A=1-22.
DR   PDBsum; 5I55; -.
DR   PDBsum; 5KGY; -.
DR   PDBsum; 6GQ2; -.
DR   PDBsum; 6GQ5; -.
DR   PDBsum; 6GQC; -.
DR   AlphaFoldDB; P0C805; -.
DR   SMR; P0C805; -.
DR   GeneID; 66840985; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR031429; PSM_alpha.
DR   Pfam; PF17063; PSMalpha; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytolysis; Reference proteome; Virulence.
FT   PEPTIDE         1..22
FT                   /note="Phenol-soluble modulin alpha 3 peptide"
FT                   /id="PRO_0000345060"
FT   HELIX           3..19
FT                   /evidence="ECO:0007829|PDB:6GQC"
SQ   SEQUENCE   22 AA;  2607 MW;  66313C34F671C8C7 CRC64;
     MEFVAKLFKF FKDLLGKFLG NN