PSMA3_STAAC
ID PSMA3_STAAC Reviewed; 22 AA.
AC P0C808;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 25-MAY-2022, entry version 29.
DE RecName: Full=Phenol-soluble modulin alpha 3 peptide;
GN Name=psmA3; OrderedLocusNames=SACOL0493.2;
OS Staphylococcus aureus (strain COL).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93062;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COL;
RX PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- FUNCTION: Peptide which can recruit, activate and subsequently lyse
CC human neutrophils, thus eliminating the main cellular defense against
CC infection. {ECO:0000250|UniProtKB:A9JX07}.
CC -!- SIMILARITY: Belongs to the phenol-soluble modulin alpha peptides
CC family. {ECO:0000305}.
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DR EMBL; CP000046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; WP_014373779.1; NC_002951.2.
DR AlphaFoldDB; P0C808; -.
DR SMR; P0C808; -.
DR GeneID; 66840985; -.
DR Proteomes; UP000000530; Chromosome.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR InterPro; IPR031429; PSM_alpha.
DR Pfam; PF17063; PSMalpha; 1.
PE 3: Inferred from homology;
KW Cytolysis; Virulence.
FT PEPTIDE 1..22
FT /note="Phenol-soluble modulin alpha 3 peptide"
FT /id="PRO_0000345063"
SQ SEQUENCE 22 AA; 2607 MW; 66313C34F671C8C7 CRC64;
MEFVAKLFKF FKDLLGKFLG NN