ID   PSMA3_STAAW             Reviewed;          22 AA.
AC   A9JX07;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Phenol-soluble modulin alpha 3 peptide;
GN   Name=psmA3; OrderedLocusNames=MW0406.2;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
RN   [2]
RP   PARTIAL PROTEIN SEQUENCE, FORMYLATION AT MET-1, FUNCTION AS A VIRULENCE
RP   FACTOR, IDENTIFICATION BY MASS SPECTROMETRY, AND INDUCTION BY AGR.
RX   PubMed=17994102; DOI=10.1038/nm1656;
RA   Wang R., Braughton K.R., Kretschmer D., Bach T.-H.L., Queck S.Y., Li M.,
RA   Kennedy A.D., Dorward D.W., Klebanoff S.J., Peschel A., DeLeo F.R.,
RA   Otto M.;
RT   "Identification of novel cytolytic peptides as key virulence determinants
RT   for community-associated MRSA.";
RL   Nat. Med. 13:1510-1514(2007).
CC   -!- FUNCTION: Peptide which can recruit, activate and subsequently lyse
CC       human neutrophils, thus eliminating the main cellular defense against
CC       infection. Stimulates the secretion of the chemotactic factor
CC       interleukin-8 (IL-8). Showed the most pronounced pro-inflammatory and
CC       cytolytic activities in the host, thus contributing greatly to
CC       virulence and possibly to the development of disease.
CC       {ECO:0000269|PubMed:17994102}.
CC   -!- INDUCTION: Up-regulated by agr. {ECO:0000269|PubMed:17994102}.
CC   -!- MISCELLANEOUS: Peptide production is higher in most prevalent
CC       community-associated MRSA strains than in hospital-associated MRSA
CC       strains.
CC   -!- SIMILARITY: Belongs to the phenol-soluble modulin alpha peptides
CC       family. {ECO:0000305}.
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DR   EMBL; BA000033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK006301; DAA06124.1; -; Genomic_DNA.
DR   RefSeq; WP_014373779.1; NC_003923.1.
DR   AlphaFoldDB; A9JX07; -.
DR   SMR; A9JX07; -.
DR   GeneID; 66840985; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR031429; PSM_alpha.
DR   Pfam; PF17063; PSMalpha; 1.
PE   1: Evidence at protein level;
KW   Cytolysis; Direct protein sequencing; Formylation; Virulence.
FT   PEPTIDE         1..22
FT                   /note="Phenol-soluble modulin alpha 3 peptide"
FT                   /id="PRO_0000345070"
FT   MOD_RES         1
FT                   /note="N-formylmethionine"
FT                   /evidence="ECO:0000269|PubMed:17994102"
SQ   SEQUENCE   22 AA;  2607 MW;  66313C34F671C8C7 CRC64;
     MEFVAKLFKF FKDLLGKFLG NN