ID   PSMA4_STAA3             Reviewed;          20 AA.
AC   P0C817;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Phenol-soluble modulin alpha 4 peptide;
GN   Name=psmA4; OrderedLocusNames=SAUSA300_0424.1;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
RN   [2]
RP   FUNCTION AS A VIRULENCE FACTOR, IDENTIFICATION BY MASS SPECTROMETRY, AND
RP   INDUCTION BY AGR.
RX   PubMed=17994102; DOI=10.1038/nm1656;
RA   Wang R., Braughton K.R., Kretschmer D., Bach T.-H.L., Queck S.Y., Li M.,
RA   Kennedy A.D., Dorward D.W., Klebanoff S.J., Peschel A., DeLeo F.R.,
RA   Otto M.;
RT   "Identification of novel cytolytic peptides as key virulence determinants
RT   for community-associated MRSA.";
RL   Nat. Med. 13:1510-1514(2007).
CC   -!- FUNCTION: Peptide which can recruit, activate and subsequently lyse
CC       human neutrophils, thus eliminating the main cellular defense against
CC       infection. Stimulates the secretion of the chemotactic factor
CC       interleukin-8 (IL-8). The ensuing activation process triggers an
CC       inflammatory response in the host, thus contributing greatly to
CC       virulence. Also possesses hemolytic activity, which may contribute to
CC       the development of disease. {ECO:0000269|PubMed:17994102}.
CC   -!- INDUCTION: Up-regulated by agr. {ECO:0000269|PubMed:17994102}.
CC   -!- MISCELLANEOUS: Peptide production is higher in most prevalent
CC       community-associated MRSA strains than in hospital-associated MRSA
CC       strains.
CC   -!- SIMILARITY: Belongs to the phenol-soluble modulin alpha peptides
CC       family. {ECO:0000305}.
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DR   EMBL; CP000255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P0C817; -.
DR   SMR; P0C817; -.
DR   PHI-base; PHI:6669; -.
DR   Proteomes; UP000001939; Chromosome.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR031429; PSM_alpha.
DR   Pfam; PF17063; PSMalpha; 1.
PE   1: Evidence at protein level;
KW   Cytolysis; Virulence.
FT   PEPTIDE         1..20
FT                   /note="Phenol-soluble modulin alpha 4 peptide"
FT                   /id="PRO_0000345073"
SQ   SEQUENCE   20 AA;  2172 MW;  6D59253C66E73D0E CRC64;
     MAIVGTIIKI IKAIIDIFAK