PSMA4_STAAS
ID PSMA4_STAAS Reviewed; 20 AA.
AC P0C826;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 25-MAY-2022, entry version 25.
DE RecName: Full=Phenol-soluble modulin alpha 4 peptide;
GN Name=psmA4; OrderedLocusNames=SAS0409.1;
OS Staphylococcus aureus (strain MSSA476).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=282459;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSSA476;
RX PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT for the rapid evolution of virulence and drug resistance.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC -!- FUNCTION: Peptide which can recruit, activate and subsequently lyse
CC human neutrophils, thus eliminating the main cellular defense against
CC infection. {ECO:0000250|UniProtKB:A9JX08}.
CC -!- SIMILARITY: Belongs to the phenol-soluble modulin alpha peptides
CC family. {ECO:0000305}.
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DR EMBL; BX571857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P0C826; -.
DR SMR; P0C826; -.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR InterPro; IPR031429; PSM_alpha.
DR Pfam; PF17063; PSMalpha; 1.
PE 3: Inferred from homology;
KW Cytolysis; Virulence.
FT PEPTIDE 1..20
FT /note="Phenol-soluble modulin alpha 4 peptide"
FT /id="PRO_0000345082"
SQ SEQUENCE 20 AA; 2172 MW; 6D59253C66E73D0E CRC64;
MAIVGTIIKI IKAIIDIFAK