PSMA4_STAAW
ID PSMA4_STAAW Reviewed; 20 AA.
AC A9JX08;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 25-MAY-2022, entry version 28.
DE RecName: Full=Phenol-soluble modulin alpha 4 peptide;
GN Name=psmA4; OrderedLocusNames=MW0406.1;
OS Staphylococcus aureus (strain MW2).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=196620;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MW2;
RX PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT "Genome and virulence determinants of high virulence community-acquired
RT MRSA.";
RL Lancet 359:1819-1827(2002).
RN [2]
RP PARTIAL PROTEIN SEQUENCE, FORMYLATION AT MET-1, FUNCTION AS A VIRULENCE
RP FACTOR, IDENTIFICATION BY MASS SPECTROMETRY, AND INDUCTION BY AGR.
RX PubMed=17994102; DOI=10.1038/nm1656;
RA Wang R., Braughton K.R., Kretschmer D., Bach T.-H.L., Queck S.Y., Li M.,
RA Kennedy A.D., Dorward D.W., Klebanoff S.J., Peschel A., DeLeo F.R.,
RA Otto M.;
RT "Identification of novel cytolytic peptides as key virulence determinants
RT for community-associated MRSA.";
RL Nat. Med. 13:1510-1514(2007).
CC -!- FUNCTION: Peptide which can recruit, activate and subsequently lyse
CC human neutrophils, thus eliminating the main cellular defense against
CC infection. Stimulates the secretion of the chemotactic factor
CC interleukin-8 (IL-8). The ensuing activation process triggers an
CC inflammatory response in the host, thus contributing greatly to
CC virulence. Also possesses hemolytic activity, which may contribute to
CC the development of disease. {ECO:0000269|PubMed:17994102}.
CC -!- INDUCTION: Up-regulated by agr. {ECO:0000269|PubMed:17994102}.
CC -!- MISCELLANEOUS: Peptide production is higher in most prevalent
CC community-associated MRSA strains than in hospital-associated MRSA
CC strains.
CC -!- SIMILARITY: Belongs to the phenol-soluble modulin alpha peptides
CC family. {ECO:0000305}.
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DR EMBL; BA000033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK006301; DAA06125.1; -; Genomic_DNA.
DR AlphaFoldDB; A9JX08; -.
DR SMR; A9JX08; -.
DR Proteomes; UP000000418; Chromosome.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR InterPro; IPR031429; PSM_alpha.
DR Pfam; PF17063; PSMalpha; 1.
PE 1: Evidence at protein level;
KW Cytolysis; Direct protein sequencing; Formylation; Virulence.
FT PEPTIDE 1..20
FT /note="Phenol-soluble modulin alpha 4 peptide"
FT /id="PRO_0000345084"
FT MOD_RES 1
FT /note="N-formylmethionine"
FT /evidence="ECO:0000269|PubMed:17994102"
SQ SEQUENCE 20 AA; 2172 MW; 6D59253C66E73D0E CRC64;
MAIVGTIIKI IKAIIDIFAK