ID   PSMD3_DICDI             Reviewed;         504 AA.
AC   Q1ZXD3;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=26S proteasome non-ATPase regulatory subunit 3;
DE   AltName: Full=26S proteasome regulatory subunit RPN3;
GN   Name=psmD3; ORFNames=DDB_G0288621;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16512674; DOI=10.1021/pr050350q;
RA   Reinders Y., Schulz I., Graef R., Sickmann A.;
RT   "Identification of novel centrosomal proteins in Dictyostelium discoideum
RT   by comparative proteomic approaches.";
RL   J. Proteome Res. 5:589-598(2006).
CC   -!- FUNCTION: Acts as a regulatory subunit of the 26 proteasome which is
CC       involved in the ATP-dependent degradation of ubiquitinated proteins.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The 26S proteasome is composed of a core protease, known as
CC       the 20S proteasome, capped at one or both ends by the 19S regulatory
CC       complex (RC). The RC is composed of at least 18 different subunits in
CC       two subcomplexes, the base and the lid, which form the portions
CC       proximal and distal to the 20S proteolytic core, respectively (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S3 family. {ECO:0000305}.
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DR   EMBL; AAFI02000119; EAS66838.1; -; Genomic_DNA.
DR   RefSeq; XP_001134521.1; XM_001134521.1.
DR   AlphaFoldDB; Q1ZXD3; -.
DR   SMR; Q1ZXD3; -.
DR   STRING; 44689.DDB0232980; -.
DR   PaxDb; Q1ZXD3; -.
DR   EnsemblProtists; EAS66838; EAS66838; DDB_G0288621.
DR   GeneID; 8626718; -.
DR   KEGG; ddi:DDB_G0288621; -.
DR   dictyBase; DDB_G0288621; psmD3.
DR   eggNOG; KOG2581; Eukaryota.
DR   HOGENOM; CLU_019858_1_2_1; -.
DR   InParanoid; Q1ZXD3; -.
DR   OMA; ENFGPQF; -.
DR   PhylomeDB; Q1ZXD3; -.
DR   Reactome; R-DDI-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR   Reactome; R-DDI-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR   Reactome; R-DDI-174113; SCF-beta-TrCP mediated degradation of Emi1.
DR   Reactome; R-DDI-174154; APC/C:Cdc20 mediated degradation of Securin.
DR   Reactome; R-DDI-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR   Reactome; R-DDI-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR   Reactome; R-DDI-2467813; Separation of Sister Chromatids.
DR   Reactome; R-DDI-349425; Autodegradation of the E3 ubiquitin ligase COP1.
DR   Reactome; R-DDI-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA.
DR   Reactome; R-DDI-4641258; Degradation of DVL.
DR   Reactome; R-DDI-5632684; Hedgehog 'on' state.
DR   Reactome; R-DDI-5658442; Regulation of RAS by GAPs.
DR   Reactome; R-DDI-5687128; MAPK6/MAPK4 signaling.
DR   Reactome; R-DDI-5689603; UCH proteinases.
DR   Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-68949; Orc1 removal from chromatin.
DR   Reactome; R-DDI-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR   Reactome; R-DDI-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
DR   Reactome; R-DDI-75815; Ubiquitin-dependent degradation of Cyclin D.
DR   Reactome; R-DDI-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR   Reactome; R-DDI-8948751; Regulation of PTEN stability and activity.
DR   Reactome; R-DDI-8951664; Neddylation.
DR   Reactome; R-DDI-9755511; KEAP1-NFE2L2 pathway.
DR   Reactome; R-DDI-9762114; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2.
DR   Reactome; R-DDI-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   PRO; PR:Q1ZXD3; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0000502; C:proteasome complex; ISS:dictyBase.
DR   GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:InterPro.
DR   GO; GO:0042176; P:regulation of protein catabolic process; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR013586; 26S_Psome_reg_C.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR035267; PSMD3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR10758:SF2; PTHR10758:SF2; 1.
DR   Pfam; PF01399; PCI; 1.
DR   Pfam; PF08375; Rpn3_C; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   1: Evidence at protein level;
KW   Proteasome; Reference proteome.
FT   CHAIN           1..504
FT                   /note="26S proteasome non-ATPase regulatory subunit 3"
FT                   /id="PRO_0000327455"
FT   DOMAIN          254..434
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          485..504
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   504 AA;  57439 MW;  EF6F2053561AC752 CRC64;
     MADIEMSEAS KTPVVAEEVV DPVQKANEAS LLTFADLKKN IGLIDKGVDT KEMRFIISVL
     RQTQSIRKKL NYKVLNQIVN FAFSHQNHAT KKNFLLSFLK SDGSSMDIDS TTQAEKETTP
     SSSSSHLNIE VESYIHLLVL IYLIDQKKYE DATKCSSALM ETVQSNTRIT LYPLSSKIFF
     YYSLSYEMTN NLHEVRSTLL SALRTATLRH NDEGQATIIN LLLRNYLEYN LFEQADKLLA
     NTQFPESASS NQFARYFYYQ GRIRAIQLEY AESFKFLTQA IRKAPQNTAG GFRRTVYKLL
     SIVQLLMGEI PERNTFSQKQ LKIALKPYFH LTEAVRVGDL GSFNQALEQN SDIFKSDQTF
     TLVQRLRSNV IKAGLKKLNT AYSRISFNDI CTKLKFDGTT QDIMFIIAKT IKDGVIDATI
     NYEGGYLQSR ENIDAYSTQE PLHAFSNRID ICLKIHNDSL KAMRFHPDLN KAETEKIAEV
     AKTIKEEMER QAEESSDNEG DSDF