ID   PSMD3_TOBAC             Reviewed;         488 AA.
AC   P93768;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Probable 26S proteasome non-ATPase regulatory subunit 3;
DE            Short=26S proteasome subunit S3;
DE   AltName: Full=26S proteasome regulatory subunit RPN3;
DE   AltName: Full=Nuclear antigen 21D7;
GN   Name=21D7;
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Ito M., Smith M.W., Watanabe A.;
RT   "Cloning of a cDNA encoding a tobacco homolog of the carrot 21D7 protein
RT   that is a subunit of the 26S proteasome complex.";
RL   (er) Plant Gene Register PGR97-084(1997).
CC   -!- FUNCTION: Acts as a regulatory subunit of the 26 proteasome which is
CC       involved in the ATP-dependent degradation of ubiquitinated proteins.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The 26S proteasome is composed of a core protease, known as
CC       the 20S proteasome, capped at one or both ends by the 19S regulatory
CC       complex (RC). The RC is composed of at least 18 different subunits in
CC       two subcomplexes, the base and the lid, which form the portions
CC       proximal and distal to the 20S proteolytic core, respectively (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S3 family. {ECO:0000305}.
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DR   EMBL; AB001422; BAA19252.1; -; mRNA.
DR   PIR; T02207; T02207.
DR   RefSeq; NP_001311877.1; NM_001324948.1.
DR   AlphaFoldDB; P93768; -.
DR   SMR; P93768; -.
DR   STRING; 4097.P93768; -.
DR   PRIDE; P93768; -.
DR   GeneID; 107767363; -.
DR   KEGG; nta:107767363; -.
DR   Proteomes; UP000084051; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:InterPro.
DR   GO; GO:0042176; P:regulation of protein catabolic process; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   InterPro; IPR013586; 26S_Psome_reg_C.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01399; PCI; 1.
DR   Pfam; PF08375; Rpn3_C; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Proteasome; Reference proteome.
FT   CHAIN           1..488
FT                   /note="Probable 26S proteasome non-ATPase regulatory
FT                   subunit 3"
FT                   /id="PRO_0000173825"
FT   DOMAIN          240..421
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          452..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        452..481
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  55577 MW;  99081245A1AF1694 CRC64;
     MTQDVEMKEQ AAPPSNSLSS TAPSIFHHLK EIASLIETGA YAREVRRISR AVRLTMALRK
     KLKASSLSAF LNYVLVPGSE VHSRLSSFLP KEDEQDMEVD TATSGAQAPI KNPLPELEIY
     CYLLVLIFLI DQKKYNEAKA CSSASIARLK TVNRRTVDVL ASRLYFYYSL CYELTGDLAE
     IRGYLLALHR IATLRHDELG QETLLNLLLR NYLHYNLYDQ AEKLRSKAPR FEAHSNQQFS
     RYLFYLGKIR TIQLEYTDAK ESLLQAARKA PQAALGFRVQ CNKWAIIVRL LLGEIPERTV
     FMQKGMEKAL RPYFELTNAV RIGDLELFRK VAEKFSSTFS SDGTNNLIVR LRHNVIRTGL
     RNISISYSRI SLVDVAKKLR LDSPNPVADA ESIVSKAIRD GAIDATLDHA NGWMVSKETG
     DIYSTNEPQI AFNSRIAFCL NMHNEAVRAL RFPPNSHKEK ESAEKRRERQ QQEQELAKHI
     AEEDDDDF