PSMD4_SCHMA
ID PSMD4_SCHMA Reviewed; 420 AA.
AC O17453;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=26S proteasome non-ATPase regulatory subunit 4;
DE AltName: Full=26S proteasome regulatory subunit RPN10;
DE AltName: Full=26S proteasome regulatory subunit S5A;
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Puerto Rican;
RA Harrop R., Wilson R.A.;
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Binds and presumably selects ubiquitin-conjugates for
CC destruction. {ECO:0000250}.
CC -!- SUBUNIT: The 26S proteasome is composed of a core protease, known as
CC the 20S proteasome, capped at one or both ends by the 19S regulatory
CC complex (RC). The RC is composed of at least 18 different subunits in
CC two subcomplexes, the base and the lid, which form the portions
CC proximal and distal to the 20S proteolytic core, respectively (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the proteasome subunit S5A family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB86561.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF030960; AAB86561.1; ALT_INIT; mRNA.
DR RefSeq; XP_018649562.1; XM_018795228.1.
DR AlphaFoldDB; O17453; -.
DR SMR; O17453; -.
DR STRING; 6183.Smp_000740.2; -.
DR EnsemblMetazoa; Smp_000740.1; Smp_000740.1; Smp_000740.
DR GeneID; 8343560; -.
DR KEGG; smm:Smp_000740.1; -.
DR WBParaSite; Smp_000740.1; Smp_000740.1; Smp_000740.
DR CTD; 8343560; -.
DR eggNOG; KOG2884; Eukaryota.
DR HOGENOM; CLU_033293_0_0_1; -.
DR OMA; IQGEDGM; -.
DR OrthoDB; 1244685at2759; -.
DR PhylomeDB; O17453; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR ExpressionAtlas; O17453; baseline.
DR GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF02809; UIM; 3.
DR Pfam; PF13519; VWA_2; 1.
DR SMART; SM00726; UIM; 3.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS50330; UIM; 3.
PE 2: Evidence at transcript level;
KW Proteasome; Reference proteome; Repeat.
FT CHAIN 1..420
FT /note="26S proteasome non-ATPase regulatory subunit 4"
FT /id="PRO_0000173831"
FT DOMAIN 1..174
FT /note="VWFA"
FT DOMAIN 210..229
FT /note="UIM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00213"
FT DOMAIN 255..274
FT /note="UIM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00213"
FT DOMAIN 288..307
FT /note="UIM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00213"
FT REGION 392..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 420 AA; 45728 MW; 441F8D0303B7ACD1 CRC64;
MSQEATIIAV DNSDYMRNGD FFPTRLQAQN DAVGLICQSK RQRNPENTIG LLSLANTEVL
CTLTNDVSKI YNRLHLVEPK GRIIFCSSIR IAHLALRHRQ LRHQKMRIVC FIGSPILEDE
KELTRLAKRL KKEKVNVDII NFGENETNEQ KLSEFIDTLN GKDGTGSHLI SVAPGTVLHD
TLMTSPVVAG EDGSGMAGAG LGLEFGLDGA EDPDLLYALR VSMEDQRMRQ EHEVNGDGSN
TSVVATSLPA GSGTSEEAML QQALAMSMQM NNTESSSLPM DIDLAAMSEE DQIAYALRMS
LQQMGEETTQ PTTTTLESDK TIVEPSGVAM DIDQTPTKVT ENPNLSSSSG TLAAATSAVP
TSADLDVMYD AEFLESVLQS LPGVDTQNED VRKAINALTK SQSQRGSKKD EKEDEDKQNS
