ID   PSMD5_BOVIN             Reviewed;         503 AA.
AC   Q0P5A6;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=26S proteasome non-ATPase regulatory subunit 5;
GN   Name=PSMD5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Placenta;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a chaperone during the assembly of the 26S
CC       proteasome, specifically of the base subcomplex of the PA700/19S
CC       regulatory complex (RC). In the initial step of the base subcomplex
CC       assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module
CC       which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module
CC       followed by dissociation of PSMD5 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PSMC1, PSMC2, PSMD1 and PSMD6. Part of
CC       transient complex containing PSMD5, PSMC2, PSMC1 and PSMD2 formed
CC       during the assembly of the 26S proteasome (By similarity).
CC       {ECO:0000250}.
CC   -!- DOMAIN: Rich in dileucine repeats, which have been implicated in
CC       trafficking of a variety of transmembrane proteins.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S5B/HSM3 family.
CC       {ECO:0000305}.
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DR   EMBL; BC120300; AAI20301.1; -; mRNA.
DR   RefSeq; NP_001069161.1; NM_001075693.1.
DR   AlphaFoldDB; Q0P5A6; -.
DR   SMR; Q0P5A6; -.
DR   STRING; 9913.ENSBTAP00000022548; -.
DR   PaxDb; Q0P5A6; -.
DR   PRIDE; Q0P5A6; -.
DR   GeneID; 515021; -.
DR   KEGG; bta:515021; -.
DR   CTD; 5711; -.
DR   eggNOG; KOG4413; Eukaryota.
DR   HOGENOM; CLU_043710_0_0_1; -.
DR   InParanoid; Q0P5A6; -.
DR   OrthoDB; 602046at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0022624; C:proteasome accessory complex; ISS:UniProtKB.
DR   GO; GO:0043248; P:proteasome assembly; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR019538; PSMD5.
DR   PANTHER; PTHR13554; PTHR13554; 1.
DR   Pfam; PF10508; Proteasom_PSMB; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Chaperone; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q16401"
FT   CHAIN           2..503
FT                   /note="26S proteasome non-ATPase regulatory subunit 5"
FT                   /id="PRO_0000283069"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q16401"
SQ   SEQUENCE   503 AA;  56042 MW;  6C2ACAB4F222927B CRC64;
     MAAQALALLR EVSRLEAPLE ELRALQSLLQ SVPLSELREQ AAELRLGPLF SLLNENHREQ
     TTLCVSILER LLQALEPVHV ARNLRVDLQR GLTHPNDSVK ILTLSQVGRI VENSDAVTEI
     LNNAELLKQI VYCIGGENLS VAKTAIKSLS RISLTQAGLE ALFESNLLDD LKSVMKTNDI
     VRYRVYELIV EISSVSPESL NCCTTSGLVT QLLRELTGED VLVRATCIEM VTSLACTHHG
     RQYLAQEGVI DQISNIIVGA DADPFSSFYL PGFVKFFGNL AIMDSPQQIC ERYPIFMEKV
     FEMTESQDPT MIGVAVDTIG ILGSNVEGKQ VLQKTGTRFE RLLMKIGYQA KNASTELKIR
     CLDALSSLFY LPPEQTDDLL RMTESWFSSL SRDPLELFRG ISNQPFPELH CAALKVFTAI
     ANQPWAQKLM FNSPGFVEYV MDRSVEHDKA SKDAKYELVK ALANSKTIAE IFGNPNYLRL
     RTYLSEGPYY VKPISTTAVE GAE