ID   PSMD5_MACFA             Reviewed;         504 AA.
AC   Q5IFJ8;
DT   24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=26S proteasome non-ATPase regulatory subunit 5;
DE   AltName: Full=26S protease subunit S5 basic;
DE   AltName: Full=26S proteasome subunit S5B;
GN   Name=PSMD5;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15620360; DOI=10.1016/j.cell.2004.11.040;
RA   Dorus S., Vallender E.J., Evans P.D., Anderson J.R., Gilbert S.L.,
RA   Mahowald M., Wyckoff G.J., Malcom C.M., Lahn B.T.;
RT   "Accelerated evolution of nervous system genes in the origin of Homo
RT   sapiens.";
RL   Cell 119:1027-1040(2004).
CC   -!- FUNCTION: Acts as a chaperone during the assembly of the 26S
CC       proteasome, specifically of the base subcomplex of the PA700/19S
CC       regulatory complex (RC). In the initial step of the base subcomplex
CC       assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module
CC       which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module
CC       followed by dissociation of PSMD5 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PSMC1, PSMC2, PSMD1 and PSMD6. Part of
CC       transient complex containing PSMD5, PSMC2, PSMC1 and PSMD2 formed
CC       during the assembly of the 26S proteasome (By similarity).
CC       {ECO:0000250}.
CC   -!- DOMAIN: Rich in dileucine repeats, which have been implicated in
CC       trafficking of a variety of transmembrane proteins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S5B/HSM3 family.
CC       {ECO:0000305}.
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DR   EMBL; AY742819; AAW55577.1; -; mRNA.
DR   RefSeq; NP_001272045.1; NM_001285116.1.
DR   AlphaFoldDB; Q5IFJ8; -.
DR   SMR; Q5IFJ8; -.
DR   STRING; 9541.XP_005580982.1; -.
DR   GeneID; 102129114; -.
DR   CTD; 5711; -.
DR   eggNOG; KOG4413; Eukaryota.
DR   OrthoDB; 602046at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0022624; C:proteasome accessory complex; ISS:UniProtKB.
DR   GO; GO:0043248; P:proteasome assembly; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR019538; PSMD5.
DR   PANTHER; PTHR13554; PTHR13554; 1.
DR   Pfam; PF10508; Proteasom_PSMB; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Chaperone; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q16401"
FT   CHAIN           2..504
FT                   /note="26S proteasome non-ATPase regulatory subunit 5"
FT                   /id="PRO_0000173836"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q16401"
SQ   SEQUENCE   504 AA;  56146 MW;  067DBBF5BDDFB40B CRC64;
     MAAQALALLR EVARLEAPLE ELRALHSVLQ AVPLNELREQ AAELRLGPLF SLLNENHREK
     TALCVSILER LLQAMEPVHV ARNLRVDLQR GLIHPDDSVK ILTLSQIGRI VENSDAVTEI
     LNNAELLKQI VYCIGGENLS VAKAAIKSLS RISLTQAGLE ALFESNLLDD LKSVMKTNDI
     VRYRVYELIV EISSVSPESL NYCTTSGLVT QLLRELTGED VLVRATCIEM VTSLAYTHHG
     RQYLAQEGVI DQISNIIVGA DSDPFSSFYL PGFVKFFGNL AVMDSPQQIC ERYPIFVEKV
     FEMTESQDPT MTGVAVDTVG ILGSNVEGKQ VLQKTGTRFE RLLMRIGHQS KNAPVELKIR
     CLDAISSLLY LPPEQQTDDL LRMTESWFSA LSRDPLELFR GISSQPFPEL HCAALKVFTA
     IANQPWAQKL MFNIPGFVEY VVDRSVEQDK SSKDAKYELV KALANSKTIA EIFGNPNYLR
     LRTYLSEGPY YVKPVSTTAV EGAE