ID   PSMD6_BOVIN             Reviewed;         389 AA.
AC   Q3T0B2;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=26S proteasome non-ATPase regulatory subunit 6;
DE   AltName: Full=26S proteasome regulatory subunit RPN7;
GN   Name=PSMD6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the 26S proteasome, a multiprotein complex
CC       involved in the ATP-dependent degradation of ubiquitinated proteins.
CC       This complex plays a key role in the maintenance of protein homeostasis
CC       by removing misfolded or damaged proteins, which could impair cellular
CC       functions, and by removing proteins whose functions are no longer
CC       required. Therefore, the proteasome participates in numerous cellular
CC       processes, including cell cycle progression, apoptosis, or DNA damage
CC       repair. {ECO:0000250|UniProtKB:Q15008}.
CC   -!- SUBUNIT: Component of the 19S proteasome regulatory particle complex.
CC       The 26S proteasome consists of a 20S core particle (CP) and two 19S
CC       regulatory subunits (RP). The regulatory particle is made of a lid
CC       composed of 9 subunits including PSMD6, a base containing 6 ATPases and
CC       few additional components. {ECO:0000250|UniProtKB:Q15008}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S10 family.
CC       {ECO:0000305}.
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DR   EMBL; BC102468; AAI02469.1; -; mRNA.
DR   RefSeq; NP_001029821.1; NM_001034649.2.
DR   AlphaFoldDB; Q3T0B2; -.
DR   SMR; Q3T0B2; -.
DR   STRING; 9913.ENSBTAP00000020108; -.
DR   PaxDb; Q3T0B2; -.
DR   PeptideAtlas; Q3T0B2; -.
DR   PRIDE; Q3T0B2; -.
DR   GeneID; 538625; -.
DR   KEGG; bta:538625; -.
DR   CTD; 9861; -.
DR   eggNOG; KOG0687; Eukaryota.
DR   InParanoid; Q3T0B2; -.
DR   OrthoDB; 1194691at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0022624; C:proteasome accessory complex; ISS:UniProtKB.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:InterPro.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR035268; PSMD6.
DR   InterPro; IPR019585; Rpn7/CSN1.
DR   InterPro; IPR045135; Rpn7_N.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR14145; PTHR14145; 1.
DR   PANTHER; PTHR14145:SF1; PTHR14145:SF1; 1.
DR   Pfam; PF01399; PCI; 1.
DR   Pfam; PF10602; RPN7; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Proteasome; Reference proteome.
FT   CHAIN           1..389
FT                   /note="26S proteasome non-ATPase regulatory subunit 6"
FT                   /id="PRO_0000239835"
FT   DOMAIN          193..361
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   389 AA;  45533 MW;  69086C291EFD3075 CRC64;
     MPLENLEEEG LPKNPDLRIA QLRFLLSLPE HRGDAAVRDE LMAAVRDNNM APYYEALCKS
     LEWQMDVDLL NKMKKANEDE LKRLDEELED AEKNLGESEI RDAMMAKAEY LCRIGDKEGA
     LTAFRRTYDK TVALGHRLDI VFYLLRIGLF YMDNDLITRN TEKAKSLIEE GGDWDRRNRL
     KVYQGLYCVA IRDFKQAAEL FLDTVSTFTS YELMDYKTFV TYTVYVSMIA LERPDLREKV
     IKGAEILEVL HSLPAVRQYL FSLYECRYSV FFQSLAIVEQ EMKKDWLFAP HYRYYVREMR
     IHAYSQLLES YRSLTLGYMA EAFGVGVEFI DQELSRFIAA GRLHCKIDKV NEVVETNRPD
     SKNWQYQETI KKGGLLLNRV QKLSRVINM