ID   PSMD6_CAEEL             Reviewed;         410 AA.
AC   Q20585;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=26S proteasome non-ATPase regulatory subunit 6;
DE   AltName: Full=26S proteasome regulatory subunit rpn-7;
GN   Name=rpn-7; ORFNames=F49C12.8;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=26828939; DOI=10.1371/journal.pgen.1005823;
RA   Keith S.A., Maddux S.K., Zhong Y., Chinchankar M.N., Ferguson A.A.,
RA   Ghazi A., Fisher A.L.;
RT   "Graded proteasome dysfunction in Caenorhabditis elegans activates an
RT   adaptive response involving the conserved skn-1 and elt-2 transcription
RT   factors and the autophagy-lysosome pathway.";
RL   PLoS Genet. 12:E1005823-E1005823(2016).
CC   -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is
CC       involved in the ATP-dependent degradation of ubiquitinated proteins.
CC       {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in multiple tissues including the
CC       intestine, pharynx and hypodermis. {ECO:0000269|PubMed:26828939}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S10 family.
CC       {ECO:0000305}.
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DR   EMBL; Z68227; CAA92512.1; -; Genomic_DNA.
DR   PIR; T22413; T22413.
DR   RefSeq; NP_501632.1; NM_069231.6.
DR   AlphaFoldDB; Q20585; -.
DR   SMR; Q20585; -.
DR   BioGRID; 42859; 46.
DR   DIP; DIP-26993N; -.
DR   IntAct; Q20585; 2.
DR   STRING; 6239.F49C12.8; -.
DR   EPD; Q20585; -.
DR   PaxDb; Q20585; -.
DR   PeptideAtlas; Q20585; -.
DR   PRIDE; Q20585; -.
DR   EnsemblMetazoa; F49C12.8.1; F49C12.8.1; WBGene00004463.
DR   EnsemblMetazoa; F49C12.8.2; F49C12.8.2; WBGene00004463.
DR   GeneID; 177753; -.
DR   KEGG; cel:CELE_F49C12.8; -.
DR   UCSC; F49C12.8; c. elegans.
DR   CTD; 177753; -.
DR   WormBase; F49C12.8; CE03368; WBGene00004463; rpn-7.
DR   eggNOG; KOG0687; Eukaryota.
DR   GeneTree; ENSGT00510000046608; -.
DR   HOGENOM; CLU_031814_0_0_1; -.
DR   InParanoid; Q20585; -.
DR   OMA; SLYNCHY; -.
DR   OrthoDB; 1194691at2759; -.
DR   PhylomeDB; Q20585; -.
DR   Reactome; R-CEL-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
DR   Reactome; R-CEL-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR   Reactome; R-CEL-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR   Reactome; R-CEL-195253; Degradation of beta-catenin by the destruction complex.
DR   Reactome; R-CEL-349425; Autodegradation of the E3 ubiquitin ligase COP1.
DR   Reactome; R-CEL-350562; Regulation of ornithine decarboxylase (ODC).
DR   Reactome; R-CEL-382556; ABC-family proteins mediated transport.
DR   Reactome; R-CEL-4608870; Asymmetric localization of PCP proteins.
DR   Reactome; R-CEL-4641258; Degradation of DVL.
DR   Reactome; R-CEL-5632684; Hedgehog 'on' state.
DR   Reactome; R-CEL-5689603; UCH proteinases.
DR   Reactome; R-CEL-5689880; Ub-specific processing proteases.
DR   Reactome; R-CEL-6798695; Neutrophil degranulation.
DR   Reactome; R-CEL-68949; Orc1 removal from chromatin.
DR   Reactome; R-CEL-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR   Reactome; R-CEL-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR   Reactome; R-CEL-8939902; Regulation of RUNX2 expression and activity.
DR   Reactome; R-CEL-8941858; Regulation of RUNX3 expression and activity.
DR   Reactome; R-CEL-8948751; Regulation of PTEN stability and activity.
DR   Reactome; R-CEL-8951664; Neddylation.
DR   Reactome; R-CEL-9755511; KEAP1-NFE2L2 pathway.
DR   Reactome; R-CEL-9762114; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2.
DR   Reactome; R-CEL-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   PRO; PR:Q20585; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00004463; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005838; C:proteasome regulatory particle; IBA:GO_Central.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:InterPro.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR035268; PSMD6.
DR   InterPro; IPR019585; Rpn7/CSN1.
DR   InterPro; IPR045135; Rpn7_N.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR14145; PTHR14145; 1.
DR   PANTHER; PTHR14145:SF1; PTHR14145:SF1; 1.
DR   Pfam; PF01399; PCI; 1.
DR   Pfam; PF10602; RPN7; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Proteasome; Reference proteome.
FT   CHAIN           1..410
FT                   /note="26S proteasome non-ATPase regulatory subunit 6"
FT                   /id="PRO_0000173840"
FT   DOMAIN          207..382
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   410 AA;  47584 MW;  F37390A3250109EE CRC64;
     MTEAAKKSTK KPVDDGNFDK EIISRWPDLE LSQTRFMLNH PEVDSSVKEA KLEKLQETIK
     EFDMAPFYEL VCADFKIVVD ATQLAAMKAA NQKKIDEITA EVEDAEKNLG ESEVRQGLLR
     KFEYYCQIGD KDNALKAYTA TYEKTVGMGY RIDVVFAMIR VGLFFLDHHL INKFITKAKE
     LMEQGGDWER KNRLRSYEAL YRMSVRDFAG AADLFLEAVP TFGSYELMTY ENLILYTVIT
     TTFALDRPDL RTKVIRCNEV QEQLTGGGLN GTLIPVREYL ESYYDCHYDR FFIQLAALES
     ERFKFDRYLS PHFNYYSRGM RHRAYEQFLT PYKTVRIDMM AKDFGVSRAF IDRELHRLIA
     TGQLQCRIDA VNGVIEVNHR DSKNHLYKAV IKDGDILLNR IQKLARVINA