ID   PSMD8_BOVIN             Reviewed;         287 AA.
AC   Q3SYT7;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 3.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=26S proteasome non-ATPase regulatory subunit 8;
DE   AltName: Full=26S proteasome regulatory subunit RPN12;
GN   Name=PSMD8;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the 26S proteasome, a multiprotein complex
CC       involved in the ATP-dependent degradation of ubiquitinated proteins.
CC       This complex plays a key role in the maintenance of protein homeostasis
CC       by removing misfolded or damaged proteins, which could impair cellular
CC       functions, and by removing proteins whose functions are no longer
CC       required. Therefore, the proteasome participates in numerous cellular
CC       processes, including cell cycle progression, apoptosis, or DNA damage
CC       repair. {ECO:0000250|UniProtKB:P48556}.
CC   -!- SUBUNIT: Component of the 19S proteasome regulatory particle complex.
CC       The 26S proteasome consists of a 20S core particle (CP) and two 19S
CC       regulatory subunits (RP). The regulatory particle is made of a lid
CC       composed of 9 subunits including PSMD8, a base containing 6 ATPases and
CC       few additional components. Interacts with DDI2 (By similarity).
CC       Interacts with TASOR (By similarity). {ECO:0000250|UniProtKB:P48556,
CC       ECO:0000250|UniProtKB:Q9CX56}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S14 family.
CC       {ECO:0000305}.
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DR   EMBL; BC103400; AAI03401.1; -; mRNA.
DR   RefSeq; NP_001030283.1; NM_001035111.2.
DR   AlphaFoldDB; Q3SYT7; -.
DR   SMR; Q3SYT7; -.
DR   BioGRID; 169521; 1.
DR   STRING; 9913.ENSBTAP00000042312; -.
DR   PaxDb; Q3SYT7; -.
DR   PeptideAtlas; Q3SYT7; -.
DR   PRIDE; Q3SYT7; -.
DR   GeneID; 512891; -.
DR   KEGG; bta:512891; -.
DR   CTD; 5714; -.
DR   eggNOG; KOG3151; Eukaryota.
DR   InParanoid; Q3SYT7; -.
DR   OrthoDB; 1183195at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0022624; C:proteasome accessory complex; ISS:UniProtKB.
DR   GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   InterPro; IPR006746; 26S_Psome_Rpn12.
DR   InterPro; IPR033464; CSN8_PSD8_EIF3K.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR12387; PTHR12387; 1.
DR   Pfam; PF10075; CSN8_PSD8_EIF3K; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Isopeptide bond; Phosphoprotein; Proteasome; Reference proteome;
KW   Ubl conjugation.
FT   CHAIN           1..287
FT                   /note="26S proteasome non-ATPase regulatory subunit 8"
FT                   /id="PRO_0000244599"
FT   DOMAIN          99..268
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   MOD_RES         43
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P48556"
FT   CROSSLNK        234
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:P48556"
SQ   SEQUENCE   287 AA;  32538 MW;  E7FD61C19F212342 CRC64;
     MAATAVNGVA GTSSSGSAAA SGAILQAAAG MYEQLKGEWN RKSPNLSKCG EELGRLKLVL
     LELNFLPTTG TKLTKQQLIL ARDIQEIGAQ WSILRKDIPS FERYMAQLKC YYFDYKEQLP
     ESAYMHQLLG LNLLFLLSQN RVAEFHTELE RLPAKDIQTN VYIKHPVSLE QYLMEGSYNK
     VFLAKGNIPA ESYTFFIDIL LDTIRDEIAG CIEKAYEKIL FTEATRILFF NTPKKMTDYA
     KKRGWVLGIN NYYSFASQQQ KPEDTTIPST ELAKQVIEYA RQLEMIV