PSMD8_CAEEL
ID PSMD8_CAEEL Reviewed; 250 AA.
AC Q23449;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=26S proteasome non-ATPase regulatory subunit 8;
DE AltName: Full=26S proteasome regulatory subunit rpn-12;
GN Name=rpn-12 {ECO:0000312|WormBase:ZK20.5};
GN ORFNames=ZK20.5 {ECO:0000312|WormBase:ZK20.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP DISRUPTION PHENOTYPE.
RX PubMed=16710447; DOI=10.1371/journal.pgen.0020074;
RA Cui M., Kim E.B., Han M.;
RT "Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv
RT pathways in C. elegans.";
RL PLoS Genet. 2:E74-E74(2006).
CC -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in sterility.
CC {ECO:0000269|PubMed:16710447}.
CC -!- SIMILARITY: Belongs to the proteasome subunit S14 family.
CC {ECO:0000305}.
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DR EMBL; BX284602; CAA93778.1; -; Genomic_DNA.
DR PIR; T27772; T27772.
DR RefSeq; NP_496489.1; NM_064088.7.
DR AlphaFoldDB; Q23449; -.
DR SMR; Q23449; -.
DR BioGRID; 40091; 42.
DR IntAct; Q23449; 2.
DR STRING; 6239.ZK20.5.2; -.
DR World-2DPAGE; 0020:Q23449; -.
DR EPD; Q23449; -.
DR PaxDb; Q23449; -.
DR PeptideAtlas; Q23449; -.
DR EnsemblMetazoa; ZK20.5.1; ZK20.5.1; WBGene00004468.
DR GeneID; 174786; -.
DR KEGG; cel:CELE_ZK20.5; -.
DR UCSC; ZK20.5.1; c. elegans.
DR CTD; 174786; -.
DR WormBase; ZK20.5; CE06608; WBGene00004468; rpn-12.
DR eggNOG; KOG3151; Eukaryota.
DR GeneTree; ENSGT00390000014682; -.
DR HOGENOM; CLU_046003_2_0_1; -.
DR InParanoid; Q23449; -.
DR OMA; HKFMGLH; -.
DR OrthoDB; 1183195at2759; -.
DR PhylomeDB; Q23449; -.
DR Reactome; R-CEL-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
DR Reactome; R-CEL-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR Reactome; R-CEL-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR Reactome; R-CEL-195253; Degradation of beta-catenin by the destruction complex.
DR Reactome; R-CEL-349425; Autodegradation of the E3 ubiquitin ligase COP1.
DR Reactome; R-CEL-350562; Regulation of ornithine decarboxylase (ODC).
DR Reactome; R-CEL-382556; ABC-family proteins mediated transport.
DR Reactome; R-CEL-4608870; Asymmetric localization of PCP proteins.
DR Reactome; R-CEL-4641258; Degradation of DVL.
DR Reactome; R-CEL-5632684; Hedgehog 'on' state.
DR Reactome; R-CEL-5689603; UCH proteinases.
DR Reactome; R-CEL-5689880; Ub-specific processing proteases.
DR Reactome; R-CEL-68949; Orc1 removal from chromatin.
DR Reactome; R-CEL-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-CEL-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR Reactome; R-CEL-8939902; Regulation of RUNX2 expression and activity.
DR Reactome; R-CEL-8941858; Regulation of RUNX3 expression and activity.
DR Reactome; R-CEL-8948751; Regulation of PTEN stability and activity.
DR Reactome; R-CEL-8951664; Neddylation.
DR Reactome; R-CEL-9755511; KEAP1-NFE2L2 pathway.
DR Reactome; R-CEL-9762114; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2.
DR Reactome; R-CEL-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR PRO; PR:Q23449; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00004468; Expressed in adult organism and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005838; C:proteasome regulatory particle; ISS:WormBase.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR InterPro; IPR006746; 26S_Psome_Rpn12.
DR InterPro; IPR033464; CSN8_PSD8_EIF3K.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR12387; PTHR12387; 1.
DR Pfam; PF10075; CSN8_PSD8_EIF3K; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Proteasome; Reference proteome.
FT CHAIN 1..250
FT /note="26S proteasome non-ATPase regulatory subunit 8"
FT /id="PRO_0000173848"
FT DOMAIN 63..233
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ SEQUENCE 250 AA; 28795 MW; 7406538A0CE1B2DE CRC64;
MSAAHKNLLA VWAKEPKDLV AVEKALNELT KVLSASSDLN DKQSALASKD LYEISVLLAI
LKHDFETFDD YINQMHTYYT MAPENSENKH LMTGLHLMFL LAANRLSDFH MLLEQIPQKE
QTSNAYISTP VRIEQSLMEG AYNKVVLTEK NIPSPFYTIF IRIMLDTIRR EIATSIEKSF
KVLTAKDATV MLLFDNDEQM KKFGQERKWH LDGERYVFEI EVAQEKPVNL DTVRVATQTL
FYAKQLEQIV
