PSMD9_RAT
ID PSMD9_RAT Reviewed; 222 AA.
AC Q9WTV5;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=26S proteasome non-ATPase regulatory subunit 9;
DE AltName: Full=26S proteasome regulatory subunit p27;
DE AltName: Full=Transactivating protein Bridge-1;
GN Name=Psmd9;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pancreas;
RX PubMed=10567574; DOI=10.1128/mcb.19.12.8492;
RA Thomas M.K., Yao K.-M., Tenser M.S., Wong G.G., Habener J.F.;
RT "Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of
RT insulin gene transcription.";
RL Mol. Cell. Biol. 19:8492-8504(1999).
RN [2]
RP PROTEIN SEQUENCE OF 17-28; 39-73; 77-87; 92-103; 124-133 AND 211-222, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=Sprague-Dawley; TISSUE=Hippocampus;
RA Lubec G., Diao W.;
RL Submitted (APR-2007) to UniProtKB.
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Acts as a chaperone during the assembly of the 26S
CC proteasome, specifically of the base subcomplex of the PA700/19S
CC regulatory complex (RC). During the base subcomplex assembly is part of
CC an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator
CC trimer complex; PSMD9 is released during the further base assembly
CC process (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PSMC3. Part of a transient complex (modulator)
CC containing PSMD9, PSMC6 and PSMC3 formed during the assembly of the 26S
CC proteasome (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q9WTV5; P52947: Pdx1; NbExp=3; IntAct=EBI-7626072, EBI-7626093;
CC -!- SIMILARITY: Belongs to the proteasome subunit p27 family.
CC {ECO:0000305}.
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DR EMBL; AF067728; AAD32925.1; -; mRNA.
DR RefSeq; NP_569114.1; NM_130430.1.
DR AlphaFoldDB; Q9WTV5; -.
DR SMR; Q9WTV5; -.
DR BioGRID; 250907; 2.
DR IntAct; Q9WTV5; 1.
DR MINT; Q9WTV5; -.
DR STRING; 10116.ENSRNOP00000054528; -.
DR iPTMnet; Q9WTV5; -.
DR PhosphoSitePlus; Q9WTV5; -.
DR jPOST; Q9WTV5; -.
DR PaxDb; Q9WTV5; -.
DR PRIDE; Q9WTV5; -.
DR GeneID; 161475; -.
DR KEGG; rno:161475; -.
DR UCSC; RGD:621110; rat.
DR CTD; 5715; -.
DR RGD; 621110; Psmd9.
DR eggNOG; KOG3129; Eukaryota.
DR InParanoid; Q9WTV5; -.
DR OrthoDB; 1405146at2759; -.
DR PhylomeDB; Q9WTV5; -.
DR Reactome; R-RNO-1169091; Activation of NF-kappaB in B cells.
DR Reactome; R-RNO-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
DR Reactome; R-RNO-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR Reactome; R-RNO-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR Reactome; R-RNO-174154; APC/C:Cdc20 mediated degradation of Securin.
DR Reactome; R-RNO-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR Reactome; R-RNO-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR Reactome; R-RNO-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR Reactome; R-RNO-195253; Degradation of beta-catenin by the destruction complex.
DR Reactome; R-RNO-2467813; Separation of Sister Chromatids.
DR Reactome; R-RNO-349425; Autodegradation of the E3 ubiquitin ligase COP1.
DR Reactome; R-RNO-350562; Regulation of ornithine decarboxylase (ODC).
DR Reactome; R-RNO-382556; ABC-family proteins mediated transport.
DR Reactome; R-RNO-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA.
DR Reactome; R-RNO-4608870; Asymmetric localization of PCP proteins.
DR Reactome; R-RNO-4641257; Degradation of AXIN.
DR Reactome; R-RNO-4641258; Degradation of DVL.
DR Reactome; R-RNO-5358346; Hedgehog ligand biogenesis.
DR Reactome; R-RNO-5607761; Dectin-1 mediated noncanonical NF-kB signaling.
DR Reactome; R-RNO-5610780; Degradation of GLI1 by the proteasome.
DR Reactome; R-RNO-5610785; GLI3 is processed to GLI3R by the proteasome.
DR Reactome; R-RNO-5632684; Hedgehog 'on' state.
DR Reactome; R-RNO-5658442; Regulation of RAS by GAPs.
DR Reactome; R-RNO-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-RNO-5676590; NIK-->noncanonical NF-kB signaling.
DR Reactome; R-RNO-5687128; MAPK6/MAPK4 signaling.
DR Reactome; R-RNO-5689603; UCH proteinases.
DR Reactome; R-RNO-5689880; Ub-specific processing proteases.
DR Reactome; R-RNO-68867; Assembly of the pre-replicative complex.
DR Reactome; R-RNO-68949; Orc1 removal from chromatin.
DR Reactome; R-RNO-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-RNO-69481; G2/M Checkpoints.
DR Reactome; R-RNO-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
DR Reactome; R-RNO-75815; Ubiquitin-dependent degradation of Cyclin D.
DR Reactome; R-RNO-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint.
DR Reactome; R-RNO-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR Reactome; R-RNO-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR Reactome; R-RNO-8941858; Regulation of RUNX3 expression and activity.
DR Reactome; R-RNO-8948751; Regulation of PTEN stability and activity.
DR Reactome; R-RNO-8951664; Neddylation.
DR Reactome; R-RNO-9755511; KEAP1-NFE2L2 pathway.
DR Reactome; R-RNO-9762114; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2.
DR Reactome; R-RNO-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR PRO; PR:Q9WTV5; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:BHF-UCL.
DR GO; GO:0043425; F:bHLH transcription factor binding; IDA:BHF-UCL.
DR GO; GO:0008022; F:protein C-terminus binding; IPI:RGD.
DR GO; GO:0003713; F:transcription coactivator activity; IDA:BHF-UCL.
DR GO; GO:0046676; P:negative regulation of insulin secretion; IMP:BHF-UCL.
DR GO; GO:0032024; P:positive regulation of insulin secretion; IDA:BHF-UCL.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:BHF-UCL.
DR GO; GO:0070682; P:proteasome regulatory particle assembly; ISS:UniProtKB.
DR GO; GO:0097050; P:type B pancreatic cell apoptotic process; IMP:BHF-UCL.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR040815; Nas2_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035269; PSMD9.
DR PANTHER; PTHR12651; PTHR12651; 1.
DR Pfam; PF18265; Nas2_N; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
PE 1: Evidence at protein level;
KW Chaperone; Direct protein sequencing; Phosphoprotein; Reference proteome.
FT CHAIN 1..222
FT /note="26S proteasome non-ATPase regulatory subunit 9"
FT /id="PRO_0000173854"
FT DOMAIN 108..194
FT /note="PDZ"
FT MOD_RES 128
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 222 AA; 24829 MW; 731BC90C3226B88B CRC64;
MSSEEVRHRA ESSEARAAAV SDIQELMRRK EEIEAQIKAN YDVLESQKGI GMNEPLVDCE
GYPRADVDLY QVRTARHNII CLQNDHKALM KQVEEALHQL HARDKEKQAR DMAEAREEAM
NRRLASDSPA LPKAFARVNS ISPGSPASIA GLQVDDEIVE FGSVNTQNFQ SLQNVGTVVQ
HSEGKPLNVM VIRRGEKHQL RLTPTRWAGK GLLGCNITPL QR
