ID   PSME1_BOVIN             Reviewed;         249 AA.
AC   Q4U5R3; Q9TR86;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Proteasome activator complex subunit 1;
DE   AltName: Full=Proteasome activator 28 subunit alpha;
DE            Short=PA28a;
DE            Short=PA28alpha;
GN   Name=PSME1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Cao S.Z., Lee H.B., Wang A.H., Zhao X.X., Du L.X.;
RT   "Molecular cloning and characterization of bovine proteasome activator 28
RT   alpha subunit (PSME1) gene.";
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 37-58.
RC   TISSUE=Heart;
RX   PubMed=7989312; DOI=10.1016/s0021-9258(18)31717-4;
RA   Mott J.D., Pramanik B.C., Moomaw C.R., Afendis S.J., DeMartino G.N.,
RA   Slaughter C.A.;
RT   "PA28, an activator of the 20 S proteasome, is composed of two nonidentical
RT   but homologous subunits.";
RL   J. Biol. Chem. 269:31466-31471(1994).
CC   -!- FUNCTION: Implicated in immunoproteasome assembly and required for
CC       efficient antigen processing. The PA28 activator complex enhances the
CC       generation of class I binding peptides by altering the cleavage pattern
CC       of the proteasome.
CC   -!- SUBUNIT: Heterodimer of PSME1 and PSME2, which forms a hexameric ring.
CC       PSME1 can form homoheptamers.
CC   -!- SIMILARITY: Belongs to the PA28 family. {ECO:0000305}.
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DR   EMBL; DQ010410; AAY33867.1; -; mRNA.
DR   AlphaFoldDB; Q4U5R3; -.
DR   SMR; Q4U5R3; -.
DR   IntAct; Q4U5R3; 1.
DR   STRING; 9913.ENSBTAP00000028520; -.
DR   PaxDb; Q4U5R3; -.
DR   PeptideAtlas; Q4U5R3; -.
DR   PRIDE; Q4U5R3; -.
DR   eggNOG; KOG4470; Eukaryota.
DR   InParanoid; Q4U5R3; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0008537; C:proteasome activator complex; IEA:InterPro.
DR   Gene3D; 1.20.120.180; -; 1.
DR   Gene3D; 1.20.5.120; -; 1.
DR   InterPro; IPR003186; PA28_C.
DR   InterPro; IPR036997; PA28_C_sf.
DR   InterPro; IPR036996; PA28_N_sf.
DR   InterPro; IPR009077; Proteasome_activ_PA28.
DR   InterPro; IPR003185; Proteasome_activ_PA28_N.
DR   InterPro; IPR036252; Proteasome_activ_sf.
DR   PANTHER; PTHR10660; PTHR10660; 1.
DR   Pfam; PF02251; PA28_alpha; 1.
DR   Pfam; PF02252; PA28_beta; 1.
DR   SUPFAM; SSF47216; SSF47216; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Proteasome; Reference proteome.
FT   CHAIN           1..249
FT                   /note="Proteasome activator complex subunit 1"
FT                   /id="PRO_0000161778"
FT   REGION          55..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..98
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   249 AA;  28663 MW;  3813E354986F361D CRC64;
     MATLRVLPEA QAKVDVFRED LCTKTENLLG SYFPKKISEL DAFLKEPDLN EANLSNLKAP
     LDIPVPDPVK EKEKEERRKQ QEKEDKDEKK KGEDEDKGPP CGPVGCNEKI VVLLQRVKPE
     IKDVIEKLNL VTTWLQLQIP RIEDGNNFGV AVQEKVFELM TALHTKLEGF HTQISKYFSE
     RGDAVTKAAK QPHVGDYRQL VHELDEAEYR DIRLMVMEIR NAYAVLYDII LKNFEKLKKP
     RGETKGMIY