PSME1_MACFA
ID PSME1_MACFA Reviewed; 249 AA.
AC P58238;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 29-AUG-2001, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Proteasome activator complex subunit 1;
DE AltName: Full=11S regulator complex subunit alpha;
DE Short=REG-alpha;
DE AltName: Full=Activator of multicatalytic protease subunit 1;
DE AltName: Full=Proteasome activator 28 subunit alpha;
DE Short=PA28a;
DE Short=PA28alpha;
GN Name=PSME1; ORFNames=QtrA-14089;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Temporal cortex;
RA Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA Suzuki Y., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Implicated in immunoproteasome assembly and required for
CC efficient antigen processing. The PA28 activator complex enhances the
CC generation of class I binding peptides by altering the cleavage pattern
CC of the proteasome (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer of PSME1 and PSME2, which forms a hexameric ring.
CC PSME1 can form homoheptamers (By similarity). {ECO:0000250}.
CC -!- INDUCTION: By interferon gamma. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PA28 family. {ECO:0000305}.
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DR EMBL; AB060910; BAB46905.1; -; mRNA.
DR RefSeq; NP_001271536.1; NM_001284607.1.
DR AlphaFoldDB; P58238; -.
DR SMR; P58238; -.
DR STRING; 9541.XP_005560989.1; -.
DR GeneID; 102141082; -.
DR CTD; 5720; -.
DR eggNOG; KOG4470; Eukaryota.
DR OrthoDB; 1251022at2759; -.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0008537; C:proteasome activator complex; IEA:InterPro.
DR Gene3D; 1.20.120.180; -; 1.
DR Gene3D; 1.20.5.120; -; 1.
DR InterPro; IPR003186; PA28_C.
DR InterPro; IPR036997; PA28_C_sf.
DR InterPro; IPR036996; PA28_N_sf.
DR InterPro; IPR009077; Proteasome_activ_PA28.
DR InterPro; IPR003185; Proteasome_activ_PA28_N.
DR InterPro; IPR036252; Proteasome_activ_sf.
DR PANTHER; PTHR10660; PTHR10660; 1.
DR Pfam; PF02251; PA28_alpha; 1.
DR Pfam; PF02252; PA28_beta; 1.
DR SUPFAM; SSF47216; SSF47216; 1.
PE 2: Evidence at transcript level;
KW Proteasome; Reference proteome.
FT CHAIN 1..249
FT /note="Proteasome activator complex subunit 1"
FT /id="PRO_0000161780"
FT REGION 60..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..98
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 249 AA; 28635 MW; C9AA44BEC574B9E2 CRC64;
MATLRVQPEA QAKVDVFRED LCTKTENLLG SYFPKKISEL DAFLKEPALN EANLSNLKAP
LDIPVPDPVK EKEKGERKKQ QEKEDKDEKK KGEDEDKGPP CGPVNCNEKI LVLLQRLKPE
IKDVIEQLNL VTTWLQLQIP RIEDGNNFGV AVQEKVFELM TSLHTKLEGF HTQISKYFSE
RGDAVTKAAK QPHVGDYRQL VHELDEAEYR DIRLMVMEIR NAYAVLYDII LKNFEKLKKP
RGETKGMIY
