ID   PSME2_BOVIN             Reviewed;         239 AA.
AC   Q5E9G3; Q3T038; Q9TR87; Q9TR88; Q9TR89; Q9TR90;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Proteasome activator complex subunit 2;
DE   AltName: Full=Proteasome activator 28 subunit beta;
DE            Short=PA28b;
DE            Short=PA28beta;
GN   Name=PSME2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PROTEIN SEQUENCE OF 40-81; 189-203 AND 211-226.
RC   TISSUE=Heart;
RX   PubMed=7989312; DOI=10.1016/s0021-9258(18)31717-4;
RA   Mott J.D., Pramanik B.C., Moomaw C.R., Afendis S.J., DeMartino G.N.,
RA   Slaughter C.A.;
RT   "PA28, an activator of the 20 S proteasome, is composed of two nonidentical
RT   but homologous subunits.";
RL   J. Biol. Chem. 269:31466-31471(1994).
CC   -!- FUNCTION: Implicated in immunoproteasome assembly and required for
CC       efficient antigen processing. The PA28 activator complex enhances the
CC       generation of class I binding peptides by altering the cleavage pattern
CC       of the proteasome.
CC   -!- SUBUNIT: Heterodimer of PSME1 and PSME2, which forms a hexameric ring.
CC   -!- SIMILARITY: Belongs to the PA28 family. {ECO:0000305}.
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DR   EMBL; BT020957; AAX08974.1; -; mRNA.
DR   EMBL; BC102583; AAI02584.1; -; mRNA.
DR   RefSeq; NP_001014889.1; NM_001014889.1.
DR   AlphaFoldDB; Q5E9G3; -.
DR   SMR; Q5E9G3; -.
DR   CORUM; Q5E9G3; -.
DR   PeptideAtlas; Q5E9G3; -.
DR   PRIDE; Q5E9G3; -.
DR   Ensembl; ENSBTAT00000007642; ENSBTAP00000007642; ENSBTAG00000005814.
DR   GeneID; 509857; -.
DR   KEGG; bta:509857; -.
DR   CTD; 5721; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005814; -.
DR   VGNC; VGNC:33474; PSME2.
DR   eggNOG; KOG4470; Eukaryota.
DR   GeneTree; ENSGT00950000183098; -.
DR   HOGENOM; CLU_062515_0_1_1; -.
DR   InParanoid; Q5E9G3; -.
DR   OMA; KKPPKCG; -.
DR   OrthoDB; 1251022at2759; -.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000005814; Expressed in abomasum and 105 other tissues.
DR   ExpressionAtlas; Q5E9G3; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0008537; C:proteasome activator complex; IEA:InterPro.
DR   GO; GO:0061133; F:endopeptidase activator activity; IBA:GO_Central.
DR   GO; GO:0010950; P:positive regulation of endopeptidase activity; IBA:GO_Central.
DR   GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0061136; P:regulation of proteasomal protein catabolic process; IBA:GO_Central.
DR   Gene3D; 1.20.120.180; -; 1.
DR   Gene3D; 1.20.5.120; -; 1.
DR   InterPro; IPR003186; PA28_C.
DR   InterPro; IPR036997; PA28_C_sf.
DR   InterPro; IPR036996; PA28_N_sf.
DR   InterPro; IPR009077; Proteasome_activ_PA28.
DR   InterPro; IPR003185; Proteasome_activ_PA28_N.
DR   InterPro; IPR036252; Proteasome_activ_sf.
DR   PANTHER; PTHR10660; PTHR10660; 1.
DR   Pfam; PF02251; PA28_alpha; 1.
DR   Pfam; PF02252; PA28_beta; 1.
DR   SUPFAM; SSF47216; SSF47216; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; Phosphoprotein; Proteasome;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UL46"
FT   CHAIN           2..239
FT                   /note="Proteasome activator complex subunit 2"
FT                   /id="PRO_0000161784"
FT   REGION          65..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..86
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UL46"
FT   MOD_RES         10
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UL46"
SQ   SEQUENCE   239 AA;  27380 MW;  83CD95CF899C0818 CRC64;
     MAKPCGVRLS GEALKQVDVF RQNLFQEAEE FLYRFLPQKI IYLNQLLQED SFNVTDLNSL
     RAPLDIPIPD PPPKDDEMET DKQEKKEVPK CGFLPGNEKV LALLALVKPE VWTLKEKCIL
     VITWIQHLIP KIEDGNDFGV AIQEKVLERV NAVKTKVEAF QTTISKYFSE RGDAVAKASK
     ETHVMDYRAL VHERDEAVYG DLRAMVLDLR AFYAELYHII SSNLEKIVNP KGEEKPSMY