ID   PSME2_PIG               Reviewed;         239 AA.
AC   Q863Z0;
DT   09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Proteasome activator complex subunit 2;
DE   AltName: Full=Proteasome activator 28 subunit beta;
DE            Short=PA28b;
DE            Short=PA28beta;
GN   Name=PSME2;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=15373739; DOI=10.1111/j.1365-2052.2004.01176.x;
RA   Wang Y.F., Yu M., te Pas M.F.W., Yerle M., Liu B., Fan B., Xiong T.A.,
RA   Li K.;
RT   "Sequence characterization, polymorphism and chromosomal localizations of
RT   the porcine PSME1 and PSME2 genes.";
RL   Anim. Genet. 35:361-366(2004).
CC   -!- FUNCTION: Implicated in immunoproteasome assembly and required for
CC       efficient antigen processing. The PA28 activator complex enhances the
CC       generation of class I binding peptides by altering the cleavage pattern
CC       of the proteasome (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of PSME1 and PSME2, which forms a hexameric ring.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PA28 family. {ECO:0000305}.
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DR   EMBL; AF527991; AAP30879.1; -; mRNA.
DR   EMBL; AY317125; AAQ83575.1; -; Genomic_DNA.
DR   RefSeq; NP_999444.1; NM_214279.1.
DR   AlphaFoldDB; Q863Z0; -.
DR   SMR; Q863Z0; -.
DR   PaxDb; Q863Z0; -.
DR   PeptideAtlas; Q863Z0; -.
DR   PRIDE; Q863Z0; -.
DR   GeneID; 397522; -.
DR   KEGG; ssc:397522; -.
DR   CTD; 5721; -.
DR   eggNOG; KOG4470; Eukaryota.
DR   InParanoid; Q863Z0; -.
DR   OrthoDB; 1251022at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0008537; C:proteasome activator complex; IEA:InterPro.
DR   Gene3D; 1.20.120.180; -; 1.
DR   Gene3D; 1.20.5.120; -; 1.
DR   InterPro; IPR003186; PA28_C.
DR   InterPro; IPR036997; PA28_C_sf.
DR   InterPro; IPR036996; PA28_N_sf.
DR   InterPro; IPR009077; Proteasome_activ_PA28.
DR   InterPro; IPR003185; Proteasome_activ_PA28_N.
DR   InterPro; IPR036252; Proteasome_activ_sf.
DR   PANTHER; PTHR10660; PTHR10660; 1.
DR   Pfam; PF02251; PA28_alpha; 1.
DR   Pfam; PF02252; PA28_beta; 1.
DR   SUPFAM; SSF47216; SSF47216; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Phosphoprotein; Proteasome; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UL46"
FT   CHAIN           2..239
FT                   /note="Proteasome activator complex subunit 2"
FT                   /id="PRO_0000161787"
FT   REGION          65..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..86
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UL46"
FT   MOD_RES         10
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UL46"
SQ   SEQUENCE   239 AA;  27296 MW;  42569D600F90E963 CRC64;
     MAKPCGVRLS GEARKQVDVF RQNLFQEAEE FLYRFLPQKI IYLSQLLQED SLNVTDLTSL
     RAPLDIPIPD PPPKDDEMET DKQEKKEVPK CGFLPGNEKI LALLGLVKPE VWTLKEKCIL
     VITWIQHLIP KIEDGNDFGV AVQEKVLERV NAVKTKVEAF QTTISKYFSE RGDAVAKASK
     ETHVMDYRAL VHERDEAAHG ELRAMVLDLR AFYAELYHII SSNLEKIVDP KGEEKPSMY