ID   PSME4_XENLA             Reviewed;        1828 AA.
AC   Q6NRP2;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Proteasome activator complex subunit 4;
DE   AltName: Full=Proteasome activator PA200;
GN   Name=psme4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Associated component of the proteasome that specifically
CC       recognizes acetylated histones and promotes ATP- and ubiquitin-
CC       independent degradation of core histones during DNA damage response.
CC       Recognizes and binds acetylated histones via its bromodomain-like
CC       (BRDL) region and activates the proteasome by opening the gated channel
CC       for substrate entry. Binds to the core proteasome via its C-terminus,
CC       which occupies the same binding sites as the proteasomal ATPases,
CC       opening the closed structure of the proteasome via an active gating
CC       mechanism. involved in DNA damage response in somatic cells: binds to
CC       acetylated histones and promotes degradation of histones (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with the 20S and 26S proteasomes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Nucleus speckle {ECO:0000250}.
CC   -!- DOMAIN: The bromodomain-like (BRDL) region specifically recognizes and
CC       binds acetylated histones. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BLM10 family. {ECO:0000305}.
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DR   EMBL; BC070702; AAH70702.1; -; mRNA.
DR   RefSeq; NP_001084866.1; NM_001091397.1.
DR   AlphaFoldDB; Q6NRP2; -.
DR   SMR; Q6NRP2; -.
DR   DNASU; 431915; -.
DR   GeneID; 431915; -.
DR   KEGG; xla:431915; -.
DR   CTD; 431915; -.
DR   Xenbase; XB-GENE-5841450; psme4.L.
DR   OMA; GKDWSDE; -.
DR   OrthoDB; 83617at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 431915; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:1990111; C:spermatoproteasome complex; ISS:UniProtKB.
DR   GO; GO:0070577; F:lysine-acetylated histone binding; ISS:UniProtKB.
DR   GO; GO:0016504; F:peptidase activator activity; ISS:UniProtKB.
DR   GO; GO:0070628; F:proteasome binding; IEA:InterPro.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; ISS:UniProtKB.
DR   GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; ISS:UniProtKB.
DR   GO; GO:0035093; P:spermatogenesis, exchange of chromosomal proteins; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032430; Blm10_mid.
DR   InterPro; IPR035309; PSME4.
DR   InterPro; IPR021843; PSME4_C.
DR   PANTHER; PTHR32170; PTHR32170; 1.
DR   Pfam; PF16507; BLM10_mid; 1.
DR   Pfam; PF11919; DUF3437; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA damage; DNA repair; Nucleus; Proteasome; Reference proteome;
KW   Repeat.
FT   CHAIN           1..1828
FT                   /note="Proteasome activator complex subunit 4"
FT                   /id="PRO_0000280720"
FT   REPEAT          462..506
FT                   /note="HEAT 1"
FT   REPEAT          985..1024
FT                   /note="HEAT 2"
FT   REPEAT          1164..1202
FT                   /note="HEAT 3"
FT   REPEAT          1339..1377
FT                   /note="HEAT 4"
FT   REPEAT          1621..1659
FT                   /note="HEAT 5"
FT   REPEAT          1665..1703
FT                   /note="HEAT 6"
FT   REGION          1635..1723
FT                   /note="Bromodomain-like (BRDL)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   1828 AA;  210002 MW;  2133ACB3DC18271A CRC64;
     MGAGEERPEA LGFNPQKEIV YNLLLPYAHR LDRESNELLA QIKGSLGRAV RLRELWPGVL
     FWTRKLTTYI RLYGRKFSKE DHVLFVKLLY ELVTIPKLEI SMMQGFARLL ISLLKKKELL
     SREDLQLPWR PLYEMLERIL YSKTEHLGLN WFPNSVEGVL KTLVKACRPY FPDDATAEML
     QEWLPLMCPF DVTMQKAISY LELFLPTSLP PDLHCKGFRL WFDEFLTLWV SVQNLPQWEG
     HLVNLFARLA NDNIGYIDWD PYVPKIFTRI LRSLNLPVGS NQVLVPRQLA NAYDIGHAVI
     WITALMGGPS KTVQKHLTGL FNSITSFYHP SNNGRWLTKL MKLLQRLPCC IIRRLHRERY
     KKPSWLTPVP ESHRLTDQDV TDFVESIMQP VLLAMFSKTG SLEAAQALQN LALMRPELVI
     PPVLEKTYPA LETLTEPHQL TATLSCVIGV ARSLVSGGRW FPEGPTHMLP LLMRALPGVD
     PNDFSKCMIT FQFIATFSTL VPLVDCSSLL QERNDLSEVE RELCSATAEF EDFVLQFMDR
     CFALIESSAL EQTREETETE KMTHLESLVE LGLSSTFSTI LTQCSKEIFK VALEKVFNFA
     VSNIFETRVS GRMVADLCRA AVKCCPVESL KLFLPHCCNV ISHLTINDDV MNDEELDKEL
     LWKLQLLSEI TRVDGEKLLP YKEQLVQILH RTLHFTCKQG YTLSCNLLHH LLRSSTLIYP
     TEYCSVPGGF DKPLSDYFPI KDWGKPGDLW NLNIKWHVPS AEEMDFAYYL LDTFLRPELQ
     KLDLYSSGEL EMSRDEVQQC LAIVHNCLTG SGNLLPPLHG ERVTHLVTSM VSLNETKLFT
     GIDHDHSREN YRELISKTLR KLLHYILDHS EDDTKSLFLI IKIISDLLQF QGSHKHEFDS
     RWKSFTLVKK SMENRLHGKK RHIRALLIDR VMLQHELRTL TVEGCEYKKV HQDMLRDLLR
     LSTSSYGQVR NKAQQAFFTA LGTYNFCCRD LIPLVLEFLR PERQDVTQQQ FKGALYCLLG
     NHGGVCLANL HDWECIVQTW PAMISSGLSK AMSLEKPSIV RLFDDLAEKI HRQYETIGLD
     FSVPEKCIEI AILLQHAAST SSQLPHPEEL ALAIKRQGEK NVEAVQNYER LVNTLLDCVT
     QRNLPWKFEH IGIGFLSLLL RDDYVLPVRA IRYLVQCLNH DALIVRKMAI STVAGILKQL
     KRTHVKETIC PYKISGCPKP ESKLVGDRPD NQWLLYDSSN LPNTKEAWES CCFVEKTHWG
     YSSWPQNMLV YAPADQQPKV GRSREEMSEA EQIIYDHFTD EKFVDQLIKF LSLEDRKGKD
     KFNPRRFCLF KGLFRNYDDA FLPIIKPHLE RLVADSHEST QRCAAEIVAG LIRGSKHWTF
     EKVENLWNFL CELLRTALSN ITVETYSDWG TCIATSCESR DPRKLHWLFE LLLESPVSGE
     GGSFVDACRL YVLQGGLAQQ EWRVPELLHR LLMCLEPKLT QVYKNVRERI GSVLTYIFMI
     DVSLPNTAPT KSPHISDFTG RILGKLKPLM DADEEIQNHV MEENGVGEQD ERTQAIKLMK
     TILKWIMASA GRSFCTGVTE QMQLLPLLFK IAPVENDTNY DELKRDAKTC LSLMSQGLLL
     PVQVPLVLDV LRQTARSSSW HARYTVLTYI QTMVFYNLFI FIHNEESVQG VRWLILQLME
     DEQLEVREMA ATTLSGLLQC NFLTMDAAMQ AHFEALCKTR LPKKRKRESG MVGDTIPSGD
     LVKRHAGVLG LSACILSSPY DVPTWMPQLL MDLSVHLNDP QPIEMTVKKT LSNFRRTHHD
     NWQEHKQQFT DDQLIVLTDL LVSPCYYA