PSME_DICDI
ID PSME_DICDI Reviewed; 225 AA.
AC Q967U1; Q54NN9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Proteasome activator 28;
DE AltName: Full=PA28 homolog;
GN Name=psmE3; Synonyms=dpr1; ORFNames=DDB_G0285099;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, ASSOCIATION WITH THE 20S
RP PROTEASOME, AND SUBCELLULAR LOCATION.
RX PubMed=19411624; DOI=10.1128/ec.00165-08;
RA Masson P., Lundin D., Soederbom F., Young P.;
RT "Characterization of a REG/PA28 proteasome activator homolog in
RT Dictyostelium discoideum indicates that the ubiquitin- and ATP-independent
RT REGgamma proteasome is an ancient nuclear protease.";
RL Eukaryot. Cell 8:844-851(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Subunit of the 11S REG (also called PA28) proteasome
CC regulator, a doughnut-shaped homoheptamer which associates with the
CC proteasome. 11S REG-gamma activates preferentially the trypsin-like
CC catalytic subunit of the proteasome. May also be involved in cell cycle
CC regulation. {ECO:0000269|PubMed:19411624}.
CC -!- SUBUNIT: Homoheptamer. The homoheptamer associates with the 20S
CC proteasome. {ECO:0000269|PubMed:19411624}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19411624}.
CC -!- SIMILARITY: Belongs to the PA28 family. {ECO:0000305}.
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DR EMBL; AF363616; AAK39562.1; -; mRNA.
DR EMBL; AAFI02000074; EAL64862.1; -; Genomic_DNA.
DR RefSeq; XP_639877.1; XM_634785.1.
DR AlphaFoldDB; Q967U1; -.
DR SMR; Q967U1; -.
DR STRING; 44689.DDB0191141; -.
DR PaxDb; Q967U1; -.
DR EnsemblProtists; EAL64862; EAL64862; DDB_G0285099.
DR GeneID; 8624948; -.
DR KEGG; ddi:DDB_G0285099; -.
DR dictyBase; DDB_G0285099; psmE3.
DR eggNOG; KOG4470; Eukaryota.
DR HOGENOM; CLU_062515_1_0_1; -.
DR InParanoid; Q967U1; -.
DR OMA; PCNKPLC; -.
DR PhylomeDB; Q967U1; -.
DR Reactome; R-DDI-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR Reactome; R-DDI-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR Reactome; R-DDI-174113; SCF-beta-TrCP mediated degradation of Emi1.
DR Reactome; R-DDI-174154; APC/C:Cdc20 mediated degradation of Securin.
DR Reactome; R-DDI-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR Reactome; R-DDI-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR Reactome; R-DDI-2467813; Separation of Sister Chromatids.
DR Reactome; R-DDI-349425; Autodegradation of the E3 ubiquitin ligase COP1.
DR Reactome; R-DDI-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA.
DR Reactome; R-DDI-4641258; Degradation of DVL.
DR Reactome; R-DDI-5632684; Hedgehog 'on' state.
DR Reactome; R-DDI-5658442; Regulation of RAS by GAPs.
DR Reactome; R-DDI-5687128; MAPK6/MAPK4 signaling.
DR Reactome; R-DDI-5689603; UCH proteinases.
DR Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR Reactome; R-DDI-68949; Orc1 removal from chromatin.
DR Reactome; R-DDI-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-DDI-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
DR Reactome; R-DDI-75815; Ubiquitin-dependent degradation of Cyclin D.
DR Reactome; R-DDI-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR Reactome; R-DDI-8948751; Regulation of PTEN stability and activity.
DR Reactome; R-DDI-8951664; Neddylation.
DR Reactome; R-DDI-9755511; KEAP1-NFE2L2 pathway.
DR Reactome; R-DDI-9762114; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2.
DR Reactome; R-DDI-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR PRO; PR:Q967U1; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR GO; GO:0008537; C:proteasome activator complex; IEA:InterPro.
DR GO; GO:0032991; C:protein-containing complex; IDA:dictyBase.
DR GO; GO:0061133; F:endopeptidase activator activity; IBA:GO_Central.
DR GO; GO:0010950; P:positive regulation of endopeptidase activity; IBA:GO_Central.
DR GO; GO:0030163; P:protein catabolic process; IDA:dictyBase.
DR GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0061136; P:regulation of proteasomal protein catabolic process; IBA:GO_Central.
DR Gene3D; 1.20.120.180; -; 1.
DR InterPro; IPR003186; PA28_C.
DR InterPro; IPR036997; PA28_C_sf.
DR InterPro; IPR009077; Proteasome_activ_PA28.
DR InterPro; IPR036252; Proteasome_activ_sf.
DR PANTHER; PTHR10660; PTHR10660; 1.
DR Pfam; PF02252; PA28_beta; 1.
DR SUPFAM; SSF47216; SSF47216; 1.
PE 1: Evidence at protein level;
KW Nucleus; Proteasome; Reference proteome.
FT CHAIN 1..225
FT /note="Proteasome activator 28"
FT /id="PRO_0000327679"
SQ SEQUENCE 225 AA; 26226 MW; 8B9428CA8CEE4A99 CRC64;
MSKNNSTVIK MDEQVLKYKE DLYEKTVHHL KVTIPKKIAE YQELAKSYGQ NSENEQDGQT
SKKRKLDSED YVLMPIEDLI KTNRVIMETH QKFKKAYIEL IETFSVIRGW ISLNIPRIED
GNNFGVDVQE DIITQITKLE EVYTSLLDGS ESYFASRASL VKKILKHKDI EAYRYSLAQV
DEKEFTRFSF SYFDLANNYA TTYSLIVKNF AKLETPRPTN ASNIY
