PSMG2_BOVIN
ID PSMG2_BOVIN Reviewed; 264 AA.
AC Q2NL24;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Proteasome assembly chaperone 2;
GN Name=PSMG2 {ECO:0000312|EMBL:AAI11180.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1] {ECO:0000312|EMBL:AAI11180.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus {ECO:0000312|EMBL:AAI11180.1};
RC TISSUE=Liver {ECO:0000312|EMBL:AAI11180.1};
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Chaperone protein which promotes assembly of the 20S
CC proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2
CC heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes
CC assembly of the proteasome alpha subunits into the heteroheptameric
CC alpha ring and prevents alpha ring dimerization (By similarity).
CC {ECO:0000250|UniProtKB:Q969U7}.
CC -!- SUBUNIT: Forms a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer
CC interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits
CC (By similarity). {ECO:0000250|UniProtKB:Q969U7}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9EST4}.
CC -!- PTM: Degraded by the proteasome upon completion of 20S proteasome
CC maturation. {ECO:0000250|UniProtKB:Q969U7}.
CC -!- SIMILARITY: Belongs to the PSMG2 family. {ECO:0000255}.
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DR EMBL; BC111179; AAI11180.1; -; mRNA.
DR RefSeq; NP_001039830.1; NM_001046365.2.
DR AlphaFoldDB; Q2NL24; -.
DR SMR; Q2NL24; -.
DR STRING; 9913.ENSBTAP00000013953; -.
DR PaxDb; Q2NL24; -.
DR PRIDE; Q2NL24; -.
DR Ensembl; ENSBTAT00000013953; ENSBTAP00000013953; ENSBTAG00000010552.
DR GeneID; 533993; -.
DR KEGG; bta:533993; -.
DR CTD; 56984; -.
DR VEuPathDB; HostDB:ENSBTAG00000010552; -.
DR VGNC; VGNC:33479; PSMG2.
DR eggNOG; KOG3112; Eukaryota.
DR GeneTree; ENSGT00390000018415; -.
DR HOGENOM; CLU_062640_0_1_1; -.
DR InParanoid; Q2NL24; -.
DR OMA; WKEHTGE; -.
DR OrthoDB; 1522470at2759; -.
DR TreeFam; TF105397; -.
DR Proteomes; UP000009136; Chromosome 24.
DR Bgee; ENSBTAG00000010552; Expressed in semen and 104 other tissues.
DR GO; GO:0101031; C:chaperone complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0051131; P:chaperone-mediated protein complex assembly; ISS:UniProtKB.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0043248; P:proteasome assembly; IBA:GO_Central.
DR Gene3D; 3.40.50.10900; -; 2.
DR InterPro; IPR019151; Proteasome_assmbl_chaperone_2.
DR InterPro; IPR016562; Proteasome_assmbl_chp_2_euk.
DR InterPro; IPR038389; PSMG2_sf.
DR PANTHER; PTHR12970; PTHR12970; 1.
DR Pfam; PF09754; PAC2; 1.
DR PIRSF; PIRSF010044; UCP010044; 1.
PE 2: Evidence at transcript level;
KW Chaperone; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..264
FT /note="Proteasome assembly chaperone 2"
FT /id="PRO_0000322551"
FT MOD_RES 137
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q969U7"
SQ SEQUENCE 264 AA; 29224 MW; 1C7D67BBB8BE5D11 CRC64;
MFVPSGDSVP DLAGCTLLMP AVSVGNVGQL AIDLIISTLN MHKIGYFYTD CLVPMVGNNP
YATAEENSAE LSINAEVYAL PSKKLVALQL RSIFIKYKSK SFCEKLLSWV KCSGCAKVVV
LSSSHSYHRN DLQLRSTPFR YLLTPSMQKS VQNKIQSLNW EEMEKTPCIP EIDDSEFCVR
VPGGGITKLL YDEGCSKEIP IAILLKFVSE GDNIPDALGL VEYLNEWLQI IKPHCEDPTA
SSLPWKMPSS WRLLFGSGLP PALF
