PSMG2_DANRE
ID PSMG2_DANRE Reviewed; 260 AA.
AC Q1LXS2; Q6PBR9;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Proteasome assembly chaperone 2;
DE AltName: Full=Tumor necrosis factor superfamily member 5-induced protein 1 homolog;
GN Name=psmg2 {ECO:0000312|ZFIN:ZDB-GENE-040426-1972};
GN Synonyms=tnfsf5ip1 {ECO:0000312|ZFIN:ZDB-GENE-040426-1972};
GN ORFNames=si:dkey-263o22.1, wu:fb51b11, zgc:73278;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000312|EMBL:CAK10887.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retina {ECO:0000312|EMBL:AAH59607.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Chaperone protein which promotes assembly of the 20S
CC proteasome as part of a heterodimer with psmg1. {ECO:0000250}.
CC -!- SUBUNIT: Forms a heterodimer with psmg1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9EST4}.
CC -!- PTM: Degraded by the proteasome upon completion of 20S proteasome
CC maturation. {ECO:0000250|UniProtKB:Q969U7}.
CC -!- SIMILARITY: Belongs to the PSMG2 family. {ECO:0000255}.
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DR EMBL; BX294130; CAK10887.1; -; Genomic_DNA.
DR EMBL; BC059607; AAH59607.1; -; mRNA.
DR RefSeq; NP_998197.1; NM_213032.1.
DR AlphaFoldDB; Q1LXS2; -.
DR SMR; Q1LXS2; -.
DR STRING; 7955.ENSDARP00000052239; -.
DR PaxDb; Q1LXS2; -.
DR Ensembl; ENSDART00000052240; ENSDARP00000052239; ENSDARG00000035987.
DR GeneID; 573107; -.
DR KEGG; dre:573107; -.
DR CTD; 56984; -.
DR ZFIN; ZDB-GENE-040426-1972; psmg2.
DR eggNOG; KOG3112; Eukaryota.
DR GeneTree; ENSGT00390000018415; -.
DR HOGENOM; CLU_062640_0_1_1; -.
DR InParanoid; Q1LXS2; -.
DR OMA; WKEHTGE; -.
DR OrthoDB; 1522470at2759; -.
DR PhylomeDB; Q1LXS2; -.
DR TreeFam; TF105397; -.
DR PRO; PR:Q1LXS2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000035987; Expressed in granulocyte and 28 other tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0051131; P:chaperone-mediated protein complex assembly; ISS:UniProtKB.
DR GO; GO:0043248; P:proteasome assembly; IBA:GO_Central.
DR Gene3D; 3.40.50.10900; -; 1.
DR InterPro; IPR019151; Proteasome_assmbl_chaperone_2.
DR InterPro; IPR016562; Proteasome_assmbl_chp_2_euk.
DR InterPro; IPR038389; PSMG2_sf.
DR PANTHER; PTHR12970; PTHR12970; 1.
DR Pfam; PF09754; PAC2; 1.
DR PIRSF; PIRSF010044; UCP010044; 1.
PE 2: Evidence at transcript level;
KW Chaperone; Nucleus; Reference proteome.
FT CHAIN 1..260
FT /note="Proteasome assembly chaperone 2"
FT /id="PRO_0000322554"
FT CONFLICT 110
FT /note="M -> I (in Ref. 2; AAH59607)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 260 AA; 28960 MW; A995A1BA25780759 CRC64;
MFISSGDAVP SFKGFTLILP AVSVGNVGQL AVDLLISTLN MPRVGYFHTD CLIPMAGNNP
YASSTEDAAQ LSTSAEVYSH RDLKLAVLQI RAPIIQTKVK SFRKLMISWM KSSGFLRTVL
LSSAHAYQRD DQQLHGTPLR YMLSPSLEKE ERQRFEELGW REMEKISVFP GISDSEQRLY
IPGGGVTKCL YTDCCTEDVP MAVVLIFCSE GDNIPDAFAL INCLNDWLHL LEKPTQGSVQ
WRVPPSWKLL FGSGIPPLLF
