PSMG3_MOUSE
ID PSMG3_MOUSE Reviewed; 122 AA.
AC Q9CZH3;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Proteasome assembly chaperone 3;
DE Short=PAC-3;
DE Short=mPAC3;
GN Name=Psmg3; Synonyms=Pac3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND INTERACTION WITH PSMG4 AND PROTEASOME.
RX PubMed=17707236; DOI=10.1016/j.molcel.2007.06.025;
RA Le Tallec B., Barrault M.-B., Courbeyrette R., Guerois R.,
RA Marsolier-Kergoat M.-C., Peyroche A.;
RT "20S proteasome assembly is orchestrated by two distinct pairs of
RT chaperones in yeast and in mammals.";
RL Mol. Cell 27:660-674(2007).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Chaperone protein which promotes assembly of the 20S
CC proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate
CC the correct assembly of proteasomes. {ECO:0000269|PubMed:17707236}.
CC -!- SUBUNIT: Homodimer. Interacts directly with alpha and beta subunits of
CC the 20S proteasome but dissociates before the formation of half-
CC proteasomes, probably upon recruitment of POMP (By similarity).
CC Interacts with PSMG4. {ECO:0000250, ECO:0000269|PubMed:17707236}.
CC -!- SIMILARITY: Belongs to the PSMG3 family. {ECO:0000305}.
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DR EMBL; AK012616; BAB28357.1; -; mRNA.
DR EMBL; BC027410; AAH27410.1; -; mRNA.
DR EMBL; BC058692; AAH58692.1; -; mRNA.
DR CCDS; CCDS19815.1; -.
DR RefSeq; NP_079880.1; NM_025604.3.
DR RefSeq; XP_006504789.1; XM_006504726.3.
DR AlphaFoldDB; Q9CZH3; -.
DR SMR; Q9CZH3; -.
DR IntAct; Q9CZH3; 2.
DR MINT; Q9CZH3; -.
DR STRING; 10090.ENSMUSP00000031531; -.
DR PhosphoSitePlus; Q9CZH3; -.
DR SwissPalm; Q9CZH3; -.
DR EPD; Q9CZH3; -.
DR MaxQB; Q9CZH3; -.
DR PaxDb; Q9CZH3; -.
DR PeptideAtlas; Q9CZH3; -.
DR PRIDE; Q9CZH3; -.
DR ProteomicsDB; 301866; -.
DR Antibodypedia; 10998; 69 antibodies from 18 providers.
DR DNASU; 66506; -.
DR Ensembl; ENSMUST00000031531; ENSMUSP00000031531; ENSMUSG00000029551.
DR Ensembl; ENSMUST00000182602; ENSMUSP00000138161; ENSMUSG00000029551.
DR GeneID; 66506; -.
DR KEGG; mmu:66506; -.
DR UCSC; uc009ahg.1; mouse.
DR CTD; 84262; -.
DR MGI; MGI:1913756; Psmg3.
DR VEuPathDB; HostDB:ENSMUSG00000029551; -.
DR eggNOG; KOG4828; Eukaryota.
DR GeneTree; ENSGT00390000000324; -.
DR HOGENOM; CLU_133503_1_0_1; -.
DR InParanoid; Q9CZH3; -.
DR OMA; IRTCQVW; -.
DR OrthoDB; 1469039at2759; -.
DR PhylomeDB; Q9CZH3; -.
DR TreeFam; TF300294; -.
DR BioGRID-ORCS; 66506; 24 hits in 75 CRISPR screens.
DR PRO; PR:Q9CZH3; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9CZH3; protein.
DR Bgee; ENSMUSG00000029551; Expressed in morula and 221 other tissues.
DR Genevisible; Q9CZH3; MM.
DR GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR GO; GO:0060090; F:molecular adaptor activity; ISO:MGI.
DR GO; GO:0044877; F:protein-containing complex binding; IDA:UniProtKB.
DR GO; GO:0051131; P:chaperone-mediated protein complex assembly; ISO:MGI.
DR GO; GO:0043248; P:proteasome assembly; IEA:InterPro.
DR InterPro; IPR018788; Proteasome_assmbl_chp_3.
DR PANTHER; PTHR31051; PTHR31051; 1.
DR Pfam; PF10178; PAC3; 1.
PE 1: Evidence at protein level;
KW Acetylation; Chaperone; Reference proteome.
FT CHAIN 1..122
FT /note="Proteasome assembly chaperone 3"
FT /id="PRO_0000271359"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9BT73"
SQ SEQUENCE 122 AA; 13331 MW; 1B98DF16491B6D0D CRC64;
MEDKPLVVSK QKTEVVCGVP TQVVCTAFSS HILVVVTQFG KMGTLVSLEP SNVANDISKP
VLTTRVLLGQ DEPLIHVFAK NLVAFVSQEA GNRAVLLAMA VKDKSMERLK ALKEVIRLCQ
VW
