PSMG4_MOUSE
ID PSMG4_MOUSE Reviewed; 123 AA.
AC P0C7N9;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Proteasome assembly chaperone 4;
DE Short=PAC-4;
DE Short=mPAC4;
GN Name=Psmg4; Synonyms=Pac4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND INTERACTION WITH PSMG3 AND PROTEASOME.
RX PubMed=17707236; DOI=10.1016/j.molcel.2007.06.025;
RA Le Tallec B., Barrault M.-B., Courbeyrette R., Guerois R.,
RA Marsolier-Kergoat M.-C., Peyroche A.;
RT "20S proteasome assembly is orchestrated by two distinct pairs of
RT chaperones in yeast and in mammals.";
RL Mol. Cell 27:660-674(2007).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Liver, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Chaperone protein which promotes assembly of the 20S
CC proteasome. {ECO:0000269|PubMed:17707236}.
CC -!- SUBUNIT: Interacts with PSMG3. Associates with alpha subunits of the
CC 20S proteasome. {ECO:0000269|PubMed:17707236}.
CC -!- SIMILARITY: Belongs to the PSMG4 family. {ECO:0000305}.
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DR EMBL; AC139242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC070417; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS49230.1; -.
DR RefSeq; NP_001094900.1; NM_001101430.2.
DR AlphaFoldDB; P0C7N9; -.
DR SMR; P0C7N9; -.
DR BioGRID; 213601; 1.
DR STRING; 10090.ENSMUSP00000115881; -.
DR PhosphoSitePlus; P0C7N9; -.
DR EPD; P0C7N9; -.
DR MaxQB; P0C7N9; -.
DR PaxDb; P0C7N9; -.
DR PeptideAtlas; P0C7N9; -.
DR PRIDE; P0C7N9; -.
DR ProteomicsDB; 291578; -.
DR Antibodypedia; 78115; 4 antibodies from 4 providers.
DR Ensembl; ENSMUST00000147632; ENSMUSP00000115881; ENSMUSG00000071451.
DR GeneID; 69666; -.
DR KEGG; mmu:69666; -.
DR UCSC; uc007qbe.3; mouse.
DR CTD; 389362; -.
DR MGI; MGI:1916916; Psmg4.
DR VEuPathDB; HostDB:ENSMUSG00000071451; -.
DR eggNOG; ENOG502S31R; Eukaryota.
DR GeneTree; ENSGT00390000011804; -.
DR HOGENOM; CLU_138031_0_0_1; -.
DR InParanoid; P0C7N9; -.
DR OMA; CSPRDSI; -.
DR OrthoDB; 1468993at2759; -.
DR PhylomeDB; P0C7N9; -.
DR TreeFam; TF353302; -.
DR BioGRID-ORCS; 69666; 26 hits in 69 CRISPR screens.
DR ChiTaRS; Psmg4; mouse.
DR PRO; PR:P0C7N9; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; P0C7N9; protein.
DR Bgee; ENSMUSG00000071451; Expressed in embryonic brain and 180 other tissues.
DR ExpressionAtlas; P0C7N9; baseline and differential.
DR Genevisible; P0C7N9; MM.
DR GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR GO; GO:0044877; F:protein-containing complex binding; IDA:UniProtKB.
DR GO; GO:0043248; P:proteasome assembly; IEA:InterPro.
DR InterPro; IPR032157; PAC4.
DR PANTHER; PTHR33559; PTHR33559; 1.
DR Pfam; PF16093; PAC4; 1.
PE 1: Evidence at protein level;
KW Chaperone; Reference proteome.
FT CHAIN 1..123
FT /note="Proteasome assembly chaperone 4"
FT /id="PRO_0000341398"
SQ SEQUENCE 123 AA; 13974 MW; 7A562EE4CA0826FA CRC64;
MEESRAAADA DVSLHNFSAR LWEQLVHFHV MRLTDSLFLW VGATPHLRNL AVAMCSRYDP
IPVCTSLFGD TSDTTSTGLA QRLARKTSKQ VFVSYNLSNT DSNFTLLVEN RIKEEMETFP
EKF
