ID   PSP1_CHRIL              Reviewed;         141 AA.
AC   O61704;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Plasmatocyte-spreading peptide;
DE   Flags: Precursor;
GN   Name=PSP1;
OS   Chrysodeixis includens (Soybean looper) (Pseudoplusia includens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Plusiinae; Chrysodeixis.
OX   NCBI_TaxID=689277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9753657; DOI=10.1006/bbrc.1998.9145;
RA   Clark K.D., Witherell A., Strand M.R.;
RT   "Plasmatocyte spreading peptide is encoded by an mRNA differentially
RT   expressed in tissues of the moth Pseudoplusia includens.";
RL   Biochem. Biophys. Res. Commun. 250:479-485(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 119-141.
RC   TISSUE=Hemolymph;
RX   PubMed=9287360; DOI=10.1074/jbc.272.37.23440;
RA   Clark K.D., Pech L.L., Strand M.R.;
RT   "Isolation and identification of a plasmatocyte-spreading peptide from the
RT   hemolymph of the lepidopteran insect Pseudoplusia includens.";
RL   J. Biol. Chem. 272:23440-23447(1997).
RN   [3]
RP   STRUCTURE BY NMR OF 119-141.
RC   TISSUE=Hemolymph;
RX   PubMed=9988679; DOI=10.1074/jbc.274.8.4493;
RA   Volkman B.F., Anderson M.E., Clark K.D., Hayakawa Y., Strand M.R.,
RA   Markley J.L.;
RT   "Structure of the insect cytokine peptide plasmatocyte-spreading peptide 1
RT   from Pseudoplusia includens.";
RL   J. Biol. Chem. 274:4493-4496(1999).
CC   -!- FUNCTION: Mediates the spreading of plasmatocytes to foreign surfaces.
CC       Plasmocytes are a class of hemocytes involved in insect cellular
CC       immunity.
CC   -!- SIMILARITY: Belongs to the GBP/PSP1/paralytic peptide family.
CC       {ECO:0000305}.
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DR   EMBL; AF062489; AAC16546.1; -; mRNA.
DR   PIR; JE0359; JE0359.
DR   PDB; 1B1V; NMR; -; A=119-141.
DR   PDB; 1B5N; NMR; -; A=119-141.
DR   PDBsum; 1B1V; -.
DR   PDBsum; 1B5N; -.
DR   AlphaFoldDB; O61704; -.
DR   SMR; O61704; -.
DR   EvolutionaryTrace; O61704; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   InterPro; IPR003463; GBP_PSP.
DR   Pfam; PF02425; GBP_PSP; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytokine; Direct protein sequencing; Disulfide bond; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..118
FT                   /evidence="ECO:0000269|PubMed:9287360"
FT                   /id="PRO_0000010716"
FT   PEPTIDE         119..141
FT                   /note="Plasmatocyte-spreading peptide"
FT                   /id="PRO_0000010717"
FT   REGION          46..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        125..137
FT   STRAND          122..124
FT                   /evidence="ECO:0007829|PDB:1B1V"
FT   STRAND          126..128
FT                   /evidence="ECO:0007829|PDB:1B1V"
SQ   SEQUENCE   141 AA;  14953 MW;  929B4B6D55CF21A4 CRC64;
     MKLTINILFC LILISQYNSA NGNLRDLFNN VRGSISSSAN KIRQDVKTLF HPSDKSGNKE
     SSNIVFVEDK DEGAVGPARD NKPVAVTPAP VVSTTTQASA PTVATNGTAT GGKDDKGREN
     FNGGCLAGYM RTADGRCKPT F