ID   PSP24_XENLA             Reviewed;         372 AA.
AC   P79945;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=High-affinity lysophosphatidic acid receptor;
DE   AltName: Full=PSP24;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Oocyte;
RX   PubMed=8962057; DOI=10.1073/pnas.93.25.14367;
RA   Guo Z., Liliom K., Fischer D.J., Bathurst I.C., Tomei L.D., Kiefer M.C.,
RA   Tigyi G.;
RT   "Molecular cloning of a high-affinity receptor for the growth factor-like
RT   lipid mediator lysophosphatidic acid from Xenopus oocytes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:14367-14372(1996).
CC   -!- FUNCTION: Highly selective receptor for lysophosphatidic acid (LPA), a
CC       mediator of diverse cellular activities.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; U76385; AAB37322.1; -; mRNA.
DR   RefSeq; NP_001079283.1; NM_001085814.1.
DR   AlphaFoldDB; P79945; -.
DR   SMR; P79945; -.
DR   GeneID; 378570; -.
DR   KEGG; xla:378570; -.
DR   CTD; 378570; -.
DR   Xenbase; XB-GENE-1009032; gpr45.L.
DR   OrthoDB; 742446at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 378570; Expressed in egg cell and 17 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..372
FT                   /note="High-affinity lysophosphatidic acid receptor"
FT                   /id="PRO_0000070086"
FT   TOPO_DOM        1..38
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        60..80
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..108
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        130..149
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        171..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..268
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        290..301
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..324
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        325..372
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        15
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   372 AA;  42254 MW;  888FFA4105D592C9 CRC64;
     MGCNNTALDN CMLPNLSIAT APLDLRFAFS TPLRMLLAII MILMIAIAFL GNAIVCLIVY
     QKPAMRSAIN LLLATLAFSD IMLSLFCMPF TAVTIITGSW LFGTQFCQIS AMLYWFFVLE
     GVAILLIISV DRFLIIVQRQ DKLNPHRAKI MIAASWVLSF CISLPSVVGW TLVEVPTRAP
     QCVLGYTEFS ADRVYAVMLI VAVFFIPFSV MLYSYLCILN TVRRNAVRIH THADSLCLSQ
     VSKLGLMGLQ RPHQMNVDMS FKTRAFTTIL ILFIGFSLCW LPHSVFSLLS VFSRTFYYSS
     SFYSISTCTL WLTYLKSVFN PVIYCWRIKK FREACLEFMP KTFKILPNVR GRTRRRIRPS
     TIYVCGEHQS AV