ID   PSPA_MYCTA              Reviewed;         270 AA.
AC   A5U697; P31511;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=PspA protein {ECO:0000250|UniProtKB:P9WHP5};
DE   AltName: Full=35 kDa protein {ECO:0000250|UniProtKB:P9WHP5};
GN   Name=pspA {ECO:0000250|UniProtKB:P9WHP5}; OrderedLocusNames=MRA_2770;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2119046; DOI=10.1016/0923-2508(90)90068-2;
RA   O'Connor S.P., Rumschlag H.S., Mayer L.W.;
RT   "Nucleotide sequence of the gene encoding the 35-kDa protein of
RT   Mycobacterium tuberculosis.";
RL   Res. Microbiol. 141:407-423(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
CC   -!- FUNCTION: Involved in resistance to stress. Associates with and
CC       regulates lipid droplets (LDs) homeostasis under conditions of stress
CC       and may regulate non-replicating persistence (NRP). Could be involved
CC       in preservation of envelope integrity and tolerance to surface stress.
CC       {ECO:0000250|UniProtKB:P9WHP5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P9WHP5}.
CC       Note=Localizes to the surface of lipid droplets (LDs).
CC       {ECO:0000250|UniProtKB:P9WHP5}.
CC   -!- SIMILARITY: Belongs to the PspA/IM30 family. {ECO:0000305}.
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DR   EMBL; M69187; AAA73065.1; -; Genomic_DNA.
DR   EMBL; CP000611; ABQ74547.1; -; Genomic_DNA.
DR   PIR; A60176; A60176.
DR   RefSeq; WP_003414030.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5U697; -.
DR   SMR; A5U697; -.
DR   STRING; 419947.MRA_2770; -.
DR   PRIDE; A5U697; -.
DR   EnsemblBacteria; ABQ74547; ABQ74547; MRA_2770.
DR   GeneID; 45426731; -.
DR   KEGG; mra:MRA_2770; -.
DR   eggNOG; COG1842; Bacteria.
DR   HOGENOM; CLU_048860_0_0_11; -.
DR   OMA; QNAMVLQ; -.
DR   OrthoDB; 1674247at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007157; PspA_IM30.
DR   Pfam; PF04012; PspA_IM30; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Stress response.
FT   CHAIN           1..270
FT                   /note="PspA protein"
FT                   /id="PRO_0000300065"
FT   REGION          238..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   270 AA;  29258 MW;  AB018731FF7DEC40 CRC64;
     MANPFVKAWK YLMALFSSKI DEHADPKVQI QQAIEEAQRT HQALTQQAAQ VIGNQRQLEM
     RLNRQLADIE KLQVNVRQAL TLADQATAAG DAAKATEYNN AAEAFAAQLV TAEQSVEDLK
     TLHDQALSAA AQAKKAVERN AMVLQQKIAE RTKLLSQLEQ AKMQEQVSAS LRSMSELAAP
     GNTPSLDEVR DKIERRYANA IGSAELAESS VQGRMLEVEQ AGIQMAGHSR LEQIRASMRG
     EALPAGGTTA TPRPATETSG GAIAEQPYGQ