ID   PSPA_MYCTO              Reviewed;         270 AA.
AC   P9WHP4; L0TD78; P0C5C4; P31511;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=PspA protein {ECO:0000250|UniProtKB:P9WHP5};
DE   AltName: Full=35 kDa protein {ECO:0000250|UniProtKB:P9WHP5};
GN   Name=pspA {ECO:0000250|UniProtKB:P9WHP5}; OrderedLocusNames=MT2815;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Involved in resistance to stress. Facilitates intracellular
CC       growth of M.tuberculosis. Associates with and regulates lipid droplets
CC       (LDs) homeostasis under conditions of stress and may regulate non-
CC       replicating persistence (NRP). Could be involved in preservation of
CC       envelope integrity and tolerance to surface stress.
CC       {ECO:0000250|UniProtKB:P9WHP5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P9WHP5}.
CC       Note=Localizes to the surface of lipid droplets (LDs).
CC       {ECO:0000250|UniProtKB:P9WHP5}.
CC   -!- SIMILARITY: Belongs to the PspA/IM30 family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK47135.1; -; Genomic_DNA.
DR   PIR; A60176; A60176.
DR   RefSeq; WP_003414030.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WHP4; -.
DR   SMR; P9WHP4; -.
DR   EnsemblBacteria; AAK47135; AAK47135; MT2815.
DR   GeneID; 45426731; -.
DR   KEGG; mtc:MT2815; -.
DR   PATRIC; fig|83331.31.peg.3035; -.
DR   HOGENOM; CLU_048860_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007157; PspA_IM30.
DR   Pfam; PF04012; PspA_IM30; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Stress response; Virulence.
FT   CHAIN           1..270
FT                   /note="PspA protein"
FT                   /id="PRO_0000428149"
FT   REGION          238..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   270 AA;  29258 MW;  AB018731FF7DEC40 CRC64;
     MANPFVKAWK YLMALFSSKI DEHADPKVQI QQAIEEAQRT HQALTQQAAQ VIGNQRQLEM
     RLNRQLADIE KLQVNVRQAL TLADQATAAG DAAKATEYNN AAEAFAAQLV TAEQSVEDLK
     TLHDQALSAA AQAKKAVERN AMVLQQKIAE RTKLLSQLEQ AKMQEQVSAS LRSMSELAAP
     GNTPSLDEVR DKIERRYANA IGSAELAESS VQGRMLEVEQ AGIQMAGHSR LEQIRASMRG
     EALPAGGTTA TPRPATETSG GAIAEQPYGQ