ID   PSPC1_CHICK             Reviewed;         523 AA.
AC   Q5ZK88;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Paraspeckle component 1;
GN   Name=PSPC1; ORFNames=RCJMB04_12f9;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Together with NONO, required for the formation of nuclear
CC       paraspeckles. Acts as a coactivator during transcriptional activation.
CC       Binds to RNA. May act as a regulator the circadian clock (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Cytoplasm
CC       {ECO:0000250}. Nucleus matrix {ECO:0000250}. Nucleus speckle
CC       {ECO:0000250}. Note=In punctate subnuclear structures localized
CC       adjacent to nuclear splicing speckles, called paraspeckles.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PSPC family. {ECO:0000305}.
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DR   EMBL; AJ720196; CAG31855.1; -; mRNA.
DR   RefSeq; NP_001026002.1; NM_001030831.1.
DR   AlphaFoldDB; Q5ZK88; -.
DR   SMR; Q5ZK88; -.
DR   STRING; 9031.ENSGALP00000035658; -.
DR   PaxDb; Q5ZK88; -.
DR   Ensembl; ENSGALT00000036438; ENSGALP00000035658; ENSGALG00000017142.
DR   GeneID; 418955; -.
DR   KEGG; gga:418955; -.
DR   CTD; 55269; -.
DR   VEuPathDB; HostDB:geneid_418955; -.
DR   eggNOG; KOG0115; Eukaryota.
DR   GeneTree; ENSGT00940000157358; -.
DR   HOGENOM; CLU_027185_2_1_1; -.
DR   InParanoid; Q5ZK88; -.
DR   OMA; GDGYNQA; -.
DR   OrthoDB; 1274880at2759; -.
DR   PhylomeDB; Q5ZK88; -.
DR   PRO; PR:Q5ZK88; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000017142; Expressed in spermatid and 12 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0042382; C:paraspeckles; IEA:Ensembl.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0002218; P:activation of innate immune response; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   CDD; cd12586; RRM1_PSP1; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012975; NOPS.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR034522; PSP1_RRM1.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF08075; NOPS; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Activator; Biological rhythms; Coiled coil; Cytoplasm; Nucleus;
KW   Phosphoprotein; Reference proteome; Repeat; RNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..523
FT                   /note="Paraspeckle component 1"
FT                   /id="PRO_0000297543"
FT   DOMAIN          81..153
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          155..236
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          465..523
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          282..376
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        466..494
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   523 AA;  58471 MW;  30FE215CB02195A3 CRC64;
     MAANRNLKQV RIENSSPAAP LGMVGGGGGL KGLRGLETEN EAAAMALVPG KEGGDEEQEG
     GFTIDIKSFL KPGEKSYTQR CRLFVGNLPT DITEEDFKRL FERYGEPSEV FINRDRGFGF
     IRLESRTLAE IAKAELDGTI LKSRPLRIRF ATHGAALTVK NLSPVVSNEL LEQAFSQFGP
     VERAVVVVDD RGRATGKGFV EFAAKPPARK ALERCSDGAF LLTTTPRPVV VEPMEQFDDE
     DGLPEKLMQK TQQYHKEREQ PPRFAQPGTF EFEYASRWKA LDEMEKQQRE QVDRNIREAK
     EKLEAEMEAA RHEHQLMLMR QDLMRRQEEL RRLEELRNQE LQKRKQIQLR HEEEHRRREE
     EMLRQREQEE LRRQQEGGFK PNFMDNREQE MRMGDMGPRG AINMGDAFSP APAGNQGPPP
     MMGMNMNNRG TLPGPAMGPG PSMGPEGAAN MGTPMMPDNG TVHNERFPQG GPSQMGSPLV
     SRTGSETPQP PMSGVGTVSG GPGGFGRGNP GGNFEGPNKR RRY