PSPC_BOVIN
ID PSPC_BOVIN Reviewed; 190 AA.
AC P15783; A4FV06; P15784; Q9BDX5;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 3.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Pulmonary surfactant-associated protein C;
DE Short=SP-C;
DE AltName: Full=Pulmonary surfactant-associated proteolipid SPL(Val);
DE Flags: Precursor;
GN Name=SFTPC; Synonyms=SFTP2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Belgian blue; TISSUE=Lung;
RA Danlois F., Vandenbussche G., Ruysschaert J.-M.;
RT "cDNA cloning of bovine (Belgian White and Blue breed) pulmonary
RT surfactant-associated protein C.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal lung;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PROTEIN SEQUENCE OF 25-58.
RX PubMed=3366248; DOI=10.1016/0014-5793(88)80386-7;
RA Johansson J., Joernvall H., Eklund A., Christensen N., Robertson B.,
RA Curstedt T.;
RT "Hydrophobic 3.7 kDa surfactant polypeptide: structural characterization of
RT the human and bovine forms.";
RL FEBS Lett. 232:61-64(1988).
RN [4]
RP PROTEIN SEQUENCE OF 25-58.
RX PubMed=3689402; DOI=10.1016/s0006-291x(87)80288-7;
RA Olafson R.W., Rink U., Kielland S., Yu S.-H., Chung J., Harding P.G.R.,
RA Possmayer F.;
RT "Protein sequence analysis studies on the low molecular weight hydrophobic
RT proteins associated with bovine pulmonary surfactant.";
RL Biochem. Biophys. Res. Commun. 148:1406-1411(1987).
RN [5]
RP PROTEIN SEQUENCE OF 25-34.
RX PubMed=3663690; DOI=10.1016/0005-2760(87)90070-1;
RA Yu S.-H., Chung W., Olafson R.W., Harding P.G.R., Possmayer F.;
RT "Characterization of the small hydrophobic proteins associated with
RT pulmonary surfactant.";
RL Biochim. Biophys. Acta 921:437-448(1987).
RN [6]
RP PALMITOYLATION AT CYS-28 AND CYS-29.
RX PubMed=1872406; DOI=10.1152/ajplung.1991.261.2.l118;
RA Stults J.T., Griffin P.R., Lesikar D.D., Naidu A., Moffat B., Benson B.J.;
RT "Lung surfactant protein SP-C from human, bovine, and canine sources
RT contains palmityl cysteine thioester linkages.";
RL Am. J. Physiol. 261:L118-L125(1991).
CC -!- FUNCTION: Pulmonary surfactant associated proteins promote alveolar
CC stability by lowering the surface tension at the air-liquid interface
CC in the peripheral air spaces.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, surface film.
CC -!- MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10%
CC protein. There are 4 surfactant-associated proteins: 2 collagenous,
CC carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small
CC hydrophobic proteins (SP-B and SP-C).
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DR EMBL; AF250035; AAK28414.1; -; mRNA.
DR EMBL; BC123536; AAI23537.1; -; mRNA.
DR PIR; S00609; LNBOC1.
DR RefSeq; NP_776887.1; NM_174462.4.
DR AlphaFoldDB; P15783; -.
DR SMR; P15783; -.
DR STRING; 9913.ENSBTAP00000016672; -.
DR SwissPalm; P15783; -.
DR PaxDb; P15783; -.
DR PRIDE; P15783; -.
DR GeneID; 282071; -.
DR KEGG; bta:282071; -.
DR CTD; 6440; -.
DR eggNOG; ENOG502S6QH; Eukaryota.
DR HOGENOM; CLU_087015_0_0_1; -.
DR InParanoid; P15783; -.
DR OrthoDB; 1323673at2759; -.
DR TreeFam; TF337317; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0097208; C:alveolar lamellar body; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:UniProtKB-KW.
DR InterPro; IPR007084; BRICHOS_dom.
DR InterPro; IPR001729; SP-C.
DR InterPro; IPR018051; SP-C_palmitoylation_site.
DR InterPro; IPR015091; Surfactant_protein_propep.
DR PANTHER; PTHR10800; PTHR10800; 1.
DR Pfam; PF04089; BRICHOS; 1.
DR Pfam; PF08999; SP_C-Propep; 1.
DR SMART; SM01039; BRICHOS; 1.
DR SMART; SM00019; SF_P; 1.
DR PROSITE; PS50869; BRICHOS; 1.
DR PROSITE; PS00341; SURFACT_PALMITOYL; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Gaseous exchange; Lipoprotein;
KW Palmitate; Reference proteome; Secreted; Surface film.
FT PROPEP 1..24
FT /id="PRO_0000244397"
FT CHAIN 25..58
FT /note="Pulmonary surfactant-associated protein C"
FT /id="PRO_0000183013"
FT PROPEP 59..190
FT /id="PRO_0000244398"
FT DOMAIN 94..190
FT /note="BRICHOS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00255"
FT LIPID 28
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000269|PubMed:1872406"
FT LIPID 29
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000269|PubMed:1872406"
FT DISULFID 121..182
FT /evidence="ECO:0000250"
FT CONFLICT 45
FT /note="L -> V (in Ref. 4; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 46
FT /note="V -> L (in Ref. 3; AA sequence and 4; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 50
FT /note="I -> V (in Ref. 4; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 52..58
FT /note="GALLMGL -> IGAMLAM (in Ref. 4; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 190 AA; 20440 MW; BD9508798ABD2F43 CRC64;
MDVGSKEVLM ESPPDYTAVP GGRLLIPCCP VNIKRLLIVV VVVVLVVVVI VGALLMGLHM
SQKHTEMVLE MSITGPEAQQ RLALSERVGT TATFSIGSTG TVVYDYQRLL IAYKPAPGTC
CYIMKMAPQN IPSLEALTRK LQNFQAKPQV PSSKLGQEQG HDAGSAFSGD LAFLGRTVST
LCGEVPLYYT
