ID   PSPC_CANLF              Reviewed;          34 AA.
AC   P22397;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Pulmonary surfactant-associated protein C;
DE            Short=SP-C;
DE   AltName: Full=Pulmonary surfactant-associated proteolipid SPL(Val);
GN   Name=SFTPC; Synonyms=SFTP2;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   PROTEIN SEQUENCE, AND PALMITOYLATION AT CYS-4.
RX   PubMed=2015882; DOI=10.1016/0014-5793(91)80373-b;
RA   Johansson J., Persson P., Loewenadler B., Robertson B., Joernvall H.,
RA   Curstedt T.;
RT   "Canine hydrophobic surfactant polypeptide SP-C. A lipopeptide with one
RT   thioester-linked palmitoyl group.";
RL   FEBS Lett. 281:119-122(1991).
CC   -!- FUNCTION: Pulmonary surfactant associated proteins promote alveolar
CC       stability by lowering the surface tension at the air-liquid interface
CC       in the peripheral air spaces.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, surface film.
CC   -!- MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10%
CC       protein. There are 4 surfactant-associated proteins: 2 collagenous,
CC       carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small
CC       hydrophobic proteins (SP-B and SP-C).
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DR   PIR; B61249; LNDGC1.
DR   AlphaFoldDB; P22397; -.
DR   SMR; P22397; -.
DR   STRING; 9612.ENSCAFP00000014140; -.
DR   SwissPalm; P22397; -.
DR   PaxDb; P22397; -.
DR   eggNOG; ENOG502S6QH; Eukaryota.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:UniProtKB-KW.
DR   InterPro; IPR015091; Surfactant_protein_propep.
DR   Pfam; PF08999; SP_C-Propep; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Gaseous exchange; Lipoprotein; Palmitate;
KW   Reference proteome; Secreted; Surface film.
FT   CHAIN           1..34
FT                   /note="Pulmonary surfactant-associated protein C"
FT                   /id="PRO_0000183014"
FT   LIPID           4
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000269|PubMed:2015882"
SQ   SEQUENCE   34 AA;  3545 MW;  246AD8847D8A70B3 CRC64;
     GIPCFPSSLK RLLIIVVVIV LVVVVIVGAL LMGL