ID   PSPC_MACMU              Reviewed;         191 AA.
AC   P55152;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Pulmonary surfactant-associated protein C;
DE            Short=SP-C;
DE   AltName: Full=Pulmonary surfactant-associated proteolipid SPL(Val);
DE   Flags: Precursor;
GN   Name=SFTPC; Synonyms=SFTP2;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lung;
RA   An G., Luo G., Zhao Y., Plopper C., Wu R.;
RT   "Cloning and expression of surfactant protein C (SP-C) cDNA in monkey lung
RT   after ozone exposure.";
RL   Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Pulmonary surfactant associated proteins promote alveolar
CC       stability by lowering the surface tension at the air-liquid interface
CC       in the peripheral air spaces.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, surface film.
CC   -!- MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10%
CC       protein. There are 4 surfactant-associated proteins: 2 collagenous,
CC       carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small
CC       hydrophobic proteins (SP-B and SP-C).
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DR   EMBL; U06694; AAA17870.1; -; mRNA.
DR   PIR; G02964; G02964.
DR   RefSeq; NP_001036224.1; NM_001042759.1.
DR   AlphaFoldDB; P55152; -.
DR   SMR; P55152; -.
DR   STRING; 9544.ENSMMUP00000017109; -.
DR   GeneID; 707696; -.
DR   KEGG; mcc:707696; -.
DR   CTD; 6440; -.
DR   eggNOG; ENOG502S6QH; Eukaryota.
DR   InParanoid; P55152; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0097208; C:alveolar lamellar body; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:UniProtKB-KW.
DR   InterPro; IPR007084; BRICHOS_dom.
DR   InterPro; IPR001729; SP-C.
DR   InterPro; IPR018051; SP-C_palmitoylation_site.
DR   InterPro; IPR015091; Surfactant_protein_propep.
DR   PANTHER; PTHR10800; PTHR10800; 1.
DR   Pfam; PF04089; BRICHOS; 1.
DR   Pfam; PF08999; SP_C-Propep; 1.
DR   SMART; SM01039; BRICHOS; 1.
DR   SMART; SM00019; SF_P; 1.
DR   PROSITE; PS50869; BRICHOS; 1.
DR   PROSITE; PS00341; SURFACT_PALMITOYL; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Gaseous exchange; Lipoprotein; Palmitate;
KW   Reference proteome; Secreted; Surface film.
FT   PROPEP          1..23
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000033480"
FT   CHAIN           24..58
FT                   /note="Pulmonary surfactant-associated protein C"
FT                   /id="PRO_0000033481"
FT   PROPEP          59..191
FT                   /id="PRO_0000033482"
FT   DOMAIN          94..191
FT                   /note="BRICHOS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00255"
FT   LIPID           28
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           29
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   DISULFID        121..183
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   191 AA;  20584 MW;  4A653FB3EE94C02D CRC64;
     MDVGSKEVLM ESPPDYSAAP RGRFGIPCCP VHLKRLLIVV VVVVLVVVVI VGALLMGLHM
     SQKHTEMVLE MSIGAPEAQQ HLARSGHLVT TATFSFGSTG LVVYDYQRLL IAYKPAPGTW
     CYIMKTAPES IPSLEALTRK VQNFQAKPAV PTSKLDQVEG RDAGSAPSRG DLAFLGMAVS
     TLCGEVPLYY I